Surgical Biopsy Safe for Some Patients With Late-Stage Lung Cancer

the ONA take:

Some patients with late-stage lung cancer may be candidates for surgical biopsy, a new small study reveals. Surgical biopsy is too dangerous for most patients with late-stage disease, and less invasive methods are used such as fine-needle aspiration and core needle biopsies. But these methods often do not collect enough cancer cells for the molecular testing needed to determine if these patients could benefit from newer targeted therapies. In this study, which included 25 patients with late-stage non-small cell lung cancer, researchers found that surgical biopsy was safe. Surgical biopsy identified potentially targetable genetic mutations in 19 of the 25 patients, and resulted in changes to the treatment strategy for more than half the participants. In addition, 10 of those 19 patients meet the eligibility criteria for clinical trial for a targeted treatment. The researchers caution, however, that patients with late-stage lung cancer should be reviewed by a team of experts including lung and cancer specialists, a radiologist, and a surgeon before undergoing surgical biopsy.

Surgical Biopsy Safe for Some Patients With Late-Stage Lung Cancer
Surgical Biopsy Safe for Some Patients With Late-Stage Lung Cancer
Surgical biopsy is safe for certain late-stage lung cancer patients and could improve their chances of getting treated with newer types of drugs that target cancer-related genetic mutations, a new small study reveals. However, these less invasive techniques sometimes gather too few tumor cells to perform the molecular testing needed to prescribe newer targeted drugs, the researchers said.
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