Study Shows How Tumors Remodel Their Surroundings to Grow

the ONA take:

The loss of the p62 protein in tumor cells and the surrounding tissue can enhance the growth and progression of tumors, according to research from Sanford Burnham Medical Research Institute. The findings add to the acknowledgement that the stroma (cells and tissue surrounding a tumor) is an integral part of cancer initiation, growth, and expansion. In a previous study, the researchers demonstrated that p62 activation had tumor-promoting effects in prostate and lung cancer epithelial cells. The researchers studied the effects of p62 in the adjacent tissue in this study and found that it had the reverse effect there. The researchers hypothesize that combining treatments that inhibit tumor-promoting inflammatory signals with tumor-specific targets may be a more comprehensive approach for improved cancer outcomes.

Study Demonstrates That Tumors Remodel Their Surroundings to Grow
Study Demonstrates That Tumors Remodel Their Surroundings to Grow
A team of scientists from Sanford Burnham Medical Research Institute (Sanford-Burnham) has found that the loss of a protein called p62 in the cells and tissue surrounding a tumor can enhance the growth and progression of tumors.
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