Search for cancer therapies could be transformed by innovative technique
the ONA take:
Researchers based at the University of Illinois have now developed a technique to pinpoint novel, medically relevant products produced created by bacteria. Many companies have steered away from natural product discovery due to the difficulties developing new products, but using their new technique, the investigators quickly has success developing a novel product derived from soil bacteria. Soil bacteria has been historically a good source, as it produces antibiotics to repel competitors.
The investigators used genomics to screen the soil bacteria in their search for novel antibiotic products. As the screening takes place, compounds of interest are tagged for review. The tags add mass, allowing the researchers to detect the compounds via mass spectrometry. (The most popular method typically used to identify novel products is bioassay-guided isolation, which has the tendency to produce similar results on repeated trials by "rediscovering" the most active or abundant compounds to the exclusion of the rarer compounds, which go unnoticed.) The sensitivity of mass spectrometry allows for novel products present at lower abundance.
Research results was reported in the journal ACS Chemical Biology.
Search for new cancer therapies could be transformed by innovative technique
In a study reported in ACS Chemical Biology, University of Illinois researchers developed a new technique to quickly uncover novel, medically relevant products produced by bacteria.
Past techniques involved screening more than 10,000 samples to find a novel product, said principal investigator Doug Mitchell, assistant professor of chemistry and Institute for Genomic Biology (IGB) member.
- Novel Colonoscopy Prep Is Poised to Improve Screening Rates for Colon Cancer
- How Physical Changes From Breast Cancer Affect Self-Image: Considerations for Clinicians
- Short-Term Intervention May Have Long-term Diet Effect in Hispanic Breast Cancer Survivors
- Panobinostat Modestly Improves OS in Relapsed Multiple Myeloma
- Olanzapine Efficacious for Treatment of Breakthrough CINV
- Overall Benefits of Vaporized Nicotine Products Outweigh Harms, Says International Panel of Experts
- Sugar and Cancer: Mitigating the Affects of Diet on Cancer
- Nurse Residency Programs Can Impact Oncology Nursing Practice, Outcomes
- Implementing a Distress Screening Process for Cancer Patients
- Initiating Palliative Care in the Emergency Department
- Hydroxyurea May Improve Kidney Function in PV-Associated Nephrotic Syndrome
- Childhood Cancer Linked to Poor Diet Quality in Adult Survivors
- Atypical Teratoid/rhabdoid Tumors: Challenges and Search for Solutions
- New Research Identifies Potential Bladder Cancer Chemotherapy Side Effect
- Pseudohyperkalemia: False Potassium Levels Occur in a Patient With Lymphoma
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|