Advanced image guidance more precisely targets sarcomas, reduces long-term side effects

the ONA take:

Image-guided radiotherapy can effectively treat soft tissue sarcomas in the extremities, significantly reducing long-term side effects without effecting survival rates, according to RTOG 0630, a multi-year, multi-institution phase 2 clinical trial conducted by the Radiation Therapy Oncology Group (RTOG), now conducting research as NRG Oncology.

For this study, more than 100 patients with extremity-based soft tissue sarcomas (STS) received pretreatment radiation therapy that used advanced imaging technology to target a substantially smaller area than typically targeted in treating this type of cancer.

A series of daily presurgery images of the tumor were digitally integrated with previous scans to plan a custom-tailored radiation dose that minimized exposure to adjacent healthy tissue.

Assessments 2 years later showed that long-term side effects were 10.5%. Results from a previous study in which patients received radiation to a larger area showed long-term side effects of 37%.

“Although radiation oncology is a technologically intense discipline, wisdom in using these technologies is essential for optimal outcomes,” commented the lead author of the paper.

Advanced image guidance more precisely targets sarcomas, reduces long-term side effects
Image-guided radiotherapy can effectively treat soft tissue sarcomas in the extremities.
Using advanced imaging technology to more precisely target radiation beams to treat soft tissue cancers (sarcomas) in the extremities significantly reduces long term side effects without effecting survival rates, according to research results published online today in the Journal of Clinical Oncology.
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