Advanced image guidance more precisely targets sarcomas, reduces long-term side effects
the ONA take:
Image-guided radiotherapy can effectively treat soft tissue sarcomas in the extremities, significantly reducing long-term side effects without effecting survival rates, according to RTOG 0630, a multi-year, multi-institution phase 2 clinical trial conducted by the Radiation Therapy Oncology Group (RTOG), now conducting research as NRG Oncology.
For this study, more than 100 patients with extremity-based soft tissue sarcomas (STS) received pretreatment radiation therapy that used advanced imaging technology to target a substantially smaller area than typically targeted in treating this type of cancer.
A series of daily presurgery images of the tumor were digitally integrated with previous scans to plan a custom-tailored radiation dose that minimized exposure to adjacent healthy tissue.
Assessments 2 years later showed that long-term side effects were 10.5%. Results from a previous study in which patients received radiation to a larger area showed long-term side effects of 37%.
“Although radiation oncology is a technologically intense discipline, wisdom in using these technologies is essential for optimal outcomes,” commented the lead author of the paper.
Image-guided radiotherapy can effectively treat soft tissue sarcomas in the extremities.
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