Rapid infusion of second dose rituximab appears safe
the ONA take:
Subsequent rituximab infusions can be safely administered over 60 minutes and without steroid premedication in an experienced outpatient infusion center as long as patients are appropriately screened, according to a new study published online ahead of print in the journal Supportive Care in Cancer.
For the study, researchers enrolled 50 patients with indolent and intermediate B-cell non-Hodgkin's lymphoma receiving rituximab treatment at The Ohio State Comprehensive Cancer Center-James Cancer Hospital in Columbus, Ohio.
All patients had received the first dose of rituximab according to the manufacturer-labeled standard titration schedule and had not experienced a grade 2 or higher infusion reaction. Participants then received the subsequent infusion without steroid premedication at 100 mg/hour over 15 minutes, with the remaining amount administered over 45 minutes.
Results showed that no infusion-related reactions occurred with the 60-minute rapid infusion protocol.
Researchers found that an average of about 94 minutes were saved with rapid infusion compared with the standard second dose infusion recommendation. Moreover, oncology nurses reported 100% satisfaction with the rapid infusion protocol.
The findings suggest that rapid infusions can reduce resource utilization and improve nursing satisfaction.
Subsequent rituximab infusions can be safely administered over 60 minutes and without steroid premedication.
- Physical Activity Improves Outcomes for Patients with Breast Cancer and Survivors
- Behavior Pain Assessment Tool Measures Pain In Patients Who Cannot Communicate Verbally
- Whole Genome Sequencing Reveals that 12% of Childhood Cancer Survivors Have Mutations in Genes that Increase Cancer Risk
- Increased 5-Year Survival Rate Seen in NSCLC Subset Treated With Nivolumab
- Novel Test For Multiple Myeloma Uses Microchip, Conventional Blood Sample
- Exercise, Psychological Interventions Better for Cancer Fatigue Than Medications
- ASCO Issues Global Guidance for HPV Vaccination for Cervical Cancer Prevention
- Discharge Events Improved With Standardized Inpatient Palliative Care Consultation
- Little Opposition to Early Palliative Care for Symptom Management in Pediatric Oncology
- Updated ASTRO Guideline Bolsters Safety, Efficacy of Palliative RT for Bone Metastases
- Thyroid Cancer Incidence Increasing Among Younger, Hispanic, African American Populations
- JAK1, JAK2 Inhibition Improves Outcomes in Myeloproliferative Neoplasms, But More Is Needed
- Recommendations Against Contralateral Prophylactic Mastectomy Not Tied to Patient Satisfaction
- Self-efficacy Level Predictive of Likelihood to Follow Through With Colorectal Cancer Screening
- Chronic Myeloproliferative Neoplasms Treatment (Fact Sheet)
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|