Restoring gene function reverses cancer in common childhood leukemia

the ONA take:

Researchers in Melbourne, Australia, have shown that switching off a gene called Pax5 could cause a type of leukemia, and restoring its function could cure the disease. The discovery was made using a model of B-progenitor acute lymphoblastic leukemia (B-ALL), the most common type of cancer in children. The research has shed light on the function of Pax5, one of approximately 100 genes know to suppress human tumors. The researchers said forcing B-ALL cells to resume their normal development could provide a new strategy for treating leukemia. The genetic switch technology used to study Pax5 could also be used to understand tumor suppressor genes in other cancers.

Restoring gene function reverses cancer in common childhood leukemia
Restoring gene function reverses cancer in common childhood leukemia
A type of leukaemia can be successfully 'reversed' by coaxing the cancer cells back into normal development, researchers have demonstrated. The discovery was made using a model of B-progenitor acute lymphoblastic leukaemia, the most common cancer affecting children. Researchers showed that switching off a gene called Pax5 could cause cancer in a model of B-ALL, while restoring its function could 'cure' the disease.
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