Resection of CRC Liver Metastases Linked With Higher Risk of Death Among Elderly Patients

the ONA take:

Resection of colorectal cancer (CRC) liver metastases is associated with greater risk of postoperative mortality among elderly patients despite less aggressive treatment, according to a new study published online ahead of print in JAMA Oncology.

Although surgical resection is standard treatment for patients with CRC liver metastases, the use of this procedure and the outcomes associated with it among elderly patients is not clear. Therefore, researchers from Queen’s University in Ontario, Canada, sought to describe management and outcomes of surgical resection of CRC liver metastases in elderly patients in routine practice.

For the study, researchers retrospectively analyzed data from 1,310 patients with CRC liver metastases. Results showed that patients 75 years and older were more than 20% less likely to undergo a major liver resection of more than three segments compared with those younger than 65 years and those between 65 and 74 years. Researchers found that the incidence of 90-day mortality for patients younger than 65 years was 2%, 5% for those 65 to 74 years, and 8% for those 75 years and older. Overall survival was 49%, 44%, and 28%, respectively, suggesting that although the long-term outcomes are inferior to younger patients, elderly patients may still experience long-term survival.

Resection of CRC Liver Metastases Linked With Higher Risk of Death Among Elderly Patients
Resection of CRC Liver Metastases Linked With Higher Risk of Death Among Elderly Patients
Importance Surgical resection is standard treatment for patients with colorectal cancer (CRC) liver metastases (LM). Limited data describe practice and outcomes among elderly patients. Objective To describe management and outcomes of surgical resection of CRC LM in elderly patients in routine practice.
READ FULL ARTICLE From oncology.jamanetwork.com
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