Research team makes cancer glow to improve surgical outcomes

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Surgical resection is the most effective method for a cancer cure; however, the procedure may not remove the entire tumor, leading to local recurrence. The main reason this happens is that surgeons use their eyes and hands to distinguish cancerous tissue from noncancerous tissue during surgery. Researchers at the University of Pennsylvania have established a new strategy in which near-infrared (NIR) imaging is used to help visualize the entire tumor. First, the research team first administered a dye called indocyanine green (ICG) into mice with a type of lung cancer. ICG fluoresces a bright green under NIR light. Using this technique, the team found the ICG helped them distinguish tumors from normal tissue as early as 15 days after the mice acquired cancer. Next, the researchers evaluated the technique in eight dogs with naturally occurring lung cancer brought to Penn Vet for treatment, and achieved the same successful results. Their final step was a human clinical trial with five patients. The researchers successfully found one patient’s cancer was not a solid tumor and adjusted the treatment regimen appropriately.

Research team makes cancer glow to improve surgical outcomes
Research team makes cancer glow to improve surgical outcomes
The best way to cure most cases of cancer is to surgically remove the tumor. "Surgeons have had two things that tell where a cancer is during surgery: their eyes and their hands," said David Holt, first author on the study and professor of surgery in Penn's School of Veterinary Medicine. "This ...
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