Levofloxacin plus aminoglycoside superior to ciprofloxacin after prostate biopsy

the ONA take:

This study investigated the potential benefit of oral fluoroquinolone prophylaxis in patients undergoing transrectal ultrasound-guided (TUG) prostate biopsy.

The researchers compared two prophylactic antibiotic regimens: one dose of ciprofloxacin 500 mg combined with an aminoglycoside (AG) or one dose of levofloxacin 750 mg combined with an AG.

The ciprofloxacin group involved 535 biopsies, and the levofloxacin 654 biopsies. Total infection rate was 3.18% in the ciprofloxacin group and 2.14% in the levofloxacin group.

The rate of mild infection was 0.75% in the ciprofloxacin group and 1.22% in the levofloxacin group; however, the rate of severe infection was higher in the ciprofloxacin group compared with the levofloxacin group (2.43% vs 0.92%, respectively).

Use of a single dose of fluoroquinolone augmented with an AG is optimal prophylaxis to reduce infectious complications in patients undergoing prostate biopsy.

The researchers found that 750 mg levofloxacin is more effective than 500 mg ciprofloxacin in reducing severe infections in these patients.

Photomicrograph of a Cutaneous Biopsy
Use of single dose of fluoroquinoloneis optimal prophylaxis to reduce infectious complications in patients undergoing prostate biopsy.
To investigate whether there is benefit with a longer acting oral fluoroquinolone, we compared the rate of infection after transrectal ultrasound-guided prostate biopsy between 2 prophylactic antibiotic regimens: ciprofloxacin vs levofloxacin, each combined with an aminoglycoside (AG).
READ FULL ARTICLE From www.goldjournal.net
Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs