New study reveals signaling pathway that can lead to cancer

the ONA take:

Researchers from the University of Illinois at Chicago have discovered how cholesterol activates a cellular signaling pathway linked to cancer development. Previous studies have associated high cholesterol with certain cancers. But in this study, the researchers focused on the signaling pathways used to direct cell function. A pathway called canonical Wnt signaling encourages cell growth and division. In searching for new cholesterol-binding proteins, the research team found a binding site for cholesterol on a protein known as Dishevelled, which is involved in both canonical Wnt signaling and noncanonical Wnt signaling. The mechanism of action is when cholesterol binds to Dishevelled, it sends the signal along the canonical Wnt signaling pathway, encouraging cell growth and division. In addition, increased cholesterol within the cell membrane favors canonical Wnt signaling, which may explain how high cholesterol levels increase risk for cancer. The team says this could serve as a therapeutic target for canonical Wnt signaling-drive cancers such as colon cancer, melanoma, breast cancer, and lung cancer.

New study reveals signaling pathway that can lead to cancer
New study reveals signaling pathway that can lead to cancer
But in a new study, researchers have discovered how activates a cellular signaling pathway linked to . Previous studies have connected cholesterol to certain cancers. They explain that a pathway called canonical Wnt signaling encourages cell growth and division, an important function for development in embryonic cells.
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