Melatonin not found to improve fatigue in patients with advanced cancer
the ONA take:
According to a new study published online ahead of print in the journal Cancer, researchers at Bispebjerg Hospital in Copenhagen, Denmark, have found use of oral melatonin at a dose of 20 mg was not associated with improvement in fatigue or other symptoms in patients with advanced cancer.
For the study, researchers sought to assess the effect of melatonin on fatigue and other symptoms in patients with advanced cancer. Researchers enrolled 72 patients with stage IV cancer who reported significant fatigue and randomly assigned them to receive 1 week of melatonin 20 mg or placebo orally each night. Patients then crossed over and received the opposite treatment for 1 week.
Of those, 50 patients completed the study and 44 were 100% compliant with the interventions. Results showed no difference in physical fatigue or other quality of life measures between melatonin and placebo.
Oral melatonin was not associated with improvement in fatigue or other symptoms in patients with advanced cancer.
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