Fungal infection drug for lung transplant recipients may increase cancer, death risk

the ONA take:

A prescription drug that is commonly used to treat fungal infections in lung transplant recipients may significantly increase the risk for skin cancer and even death, according to a recent study published in the American Journal of Transplantation.

Researchers led by Sarah Arron, MD, PhD, of the UCSF High Risk Skin Cancer Clinic looked at 455 single-, double- or heart-lung transplant recipients who received their transplant between October 1991 to December 2012.

Patients were analyzed for voriconazole exposure and its impact on cutaneous squamous cell carcinoma and mortality compared to the general population.

They found that exposure to the drug resulted in a 73% greater risk for SCC, with each additional 30-day exposure increasing the risk by 3%.

While the drug significantly reduced risk of Aspergillus colonization, especially within the first year of transplantation along with a reduced all-cause mortality in these patients, it did not reduce risk of aspergillosis.

“It is important for physicians to be aware of the impact of voriconzaole on these outcomes,” said Dr. Arron. “We recommend that all providers counsel lung transplant recipients on skin cancer risk and photoprotection in addition to scheduling routine skin cancer screening with a trained dermatologist after transplantation.”

Fungal infection drug for lung transplant recipients may increase cancer, death risk
Prescription drug that is commonly used to treat fungal infections in lung transplant recipients may significantly increase the risk for skin cancer.
Voriconazole, a prescription drug commonly used to treat fungal infections in lung transplant recipients, significantly increases the risk for skin cancer and even death, according to a new study by UC San Francisco researchers. The team recommends physicians consider patient-specific factors that could modify the drug's risks and benefits, when providing care.
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