Link between Lynch syndrome, hormonal influences, and risk of endometrial cancer
the ONA take:
According to a study published in JAMA, researchers have found an association between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use for women with Lynch syndrome.
For the study, researchers analyzed data from 1,128 women with an MMR gene mutation who were included in the Colon Cancer Family Registry. Of those, 133 were diagnosed with endometrial cancer. Results showed that a later age of first menstrual cycle, having given birth, and hormonal contraceptive for 1 year or longer were associated with a reduced risk for developing endometrial cancer. Researchers found no significant association between age at the time of giving first and last birth, age at menopause, and postmenopausal hormonal use and the risk for developing endometrial cancer.
The findings potentially suggest that women with an MMR gene mutation should be counseled on the hormonal influences on the risk of endometrial cancer.
Lynch syndrome is caused by a mutation in one of the MMR genes and between 2% and 5% of endometrial cancer cases are associated with Lynch syndrome.
Researchers have found an association between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use for women with Lynch syndrome.
- Increased 5-Year Survival Rate Seen in NSCLC Subset Treated With Nivolumab
- Health Care Expansion Tied to Increased Rates of Surgical Treatment of Thyroid Cancer
- Including a PI3-Kinase Inhibitor with an PARP Inhibitor Improves Tumor Shrinkage in Patients with Resistant Ovarian Cancer
- JAK1, JAK2 Inhibition Improves Outcomes in Myeloproliferative Neoplasms, But More Is Needed
- Hormone Refractory Prostate Cancer Responds to Abiraterone Acetate in Some Cases
- Exercise, Psychological Interventions Better for Cancer Fatigue Than Medications
- ASCO Issues Global Guidance for HPV Vaccination for Cervical Cancer Prevention
- Discharge Events Improved With Standardized Inpatient Palliative Care Consultation
- Little Opposition to Early Palliative Care for Symptom Management in Pediatric Oncology
- Physical Activity Improves Outcomes for Patients with Breast Cancer and Survivors
- Primary Care Physicians Surveyed on Breast Cancer Screening Practices
- Low Acculturated Latina Women Reported Breast Cancer Treatment Experience Differently Than Other Groups
- Cost and Complication Rates Differ Among Early Breast Cancer Treatment Options
- PSA Screening Rates Level Off in United States
- CQGS Releases Standards for Surgical Care of Older Adults
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|