Link between Lynch syndrome, hormonal influences, and risk of endometrial cancer
the ONA take:
According to a study published in JAMA, researchers have found an association between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use for women with Lynch syndrome.
For the study, researchers analyzed data from 1,128 women with an MMR gene mutation who were included in the Colon Cancer Family Registry. Of those, 133 were diagnosed with endometrial cancer. Results showed that a later age of first menstrual cycle, having given birth, and hormonal contraceptive for 1 year or longer were associated with a reduced risk for developing endometrial cancer. Researchers found no significant association between age at the time of giving first and last birth, age at menopause, and postmenopausal hormonal use and the risk for developing endometrial cancer.
The findings potentially suggest that women with an MMR gene mutation should be counseled on the hormonal influences on the risk of endometrial cancer.
Lynch syndrome is caused by a mutation in one of the MMR genes and between 2% and 5% of endometrial cancer cases are associated with Lynch syndrome.
Researchers have found an association between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use for women with Lynch syndrome.
- Response to Anemia Treatment Differs in Lymphoma, Multiple Myeloma
- Fertility Preservation in Male Adolescents and Young Adults With Cancer
- Social, Psychiatric Variables Reduce Cognitive Functioning, QoL in HNC
- Impact of Prostate Cancer Diagnosis, Treatment Choice on Quality of Life
- Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer
- HPV and Cancer (Fact Sheet)
- Pain Control More Easily Achieved With Nurse-Led Education in Bone Metastases
- Acupuncture an Effective Alternative Treatment for Cancer-Related Fatigue
- Using Nutrition-Based Strategies to Manage Adverse Effects of Cancer
- Palliative Care Associated With Decreased Costs For Patients With Advanced Cancer
- Exercise May Mitigate Doxorubicin-related Cardiotoxicity
- Reduced Delayed Intensification Impacts Risk of Pediatric ALL Relapse
- Exercise May Mitigate Cardiotoxicity Associated With Doxorubicin Treatment
- Mobile Health Apps Becoming More Popular Among Patients and Clinicians
- Online Learning Modules Improve Exercise Counseling, But Not Participation
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|