Link between Lynch syndrome, hormonal influences, and risk of endometrial cancer

the ONA take:

According to a study published in JAMA, researchers have found an association between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use for women with Lynch syndrome.

For the study, researchers analyzed data from 1,128 women with an MMR gene mutation who were included in the Colon Cancer Family Registry. Of those, 133 were diagnosed with endometrial cancer. Results showed that a later age of first menstrual cycle, having given birth, and hormonal contraceptive for 1 year or longer were associated with a reduced risk for developing endometrial cancer. Researchers found no significant association between age at the time of giving first and last birth, age at menopause, and postmenopausal hormonal use and the risk for developing endometrial cancer.

The findings potentially suggest that women with an MMR gene mutation should be counseled on the hormonal influences on the risk of endometrial cancer.

Lynch syndrome is caused by a mutation in one of the MMR genes and between 2% and 5% of endometrial cancer cases are associated with Lynch syndrome.

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Researchers have found an association between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use for women with Lynch syndrome.
For women with Lynch syndrome, an association was found between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use.
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