Irradiation of regional nodes in breast cancer patients affects overall survival
the ONA take:
Irradiation of regional nodes in patients with stage I-III breast cancer has a minimal effect on overall survival, according to a recent study published in The New England Journal of Medicine; however, irradiation improved disease-free survival, distant-disease-free survival, and breast cancer mortality.
For the phase III trial, researchers enrolled 4,004 patients with positive axillary lymph nodes, or centrally or medially located primary tumors with negative lymph nodes. Patients were randomly assigned to receive whole-breast or thoracic-wall irradiation plus regional nodal irradiation or whole-breast or thoracic-wall irradiation alone.
Results showed that regional irradiation benefits patients with early stage breast cancer and acute adverse events associated with regional irradiation were modest.
However, the authors note that these results do not apply to patients with laterally located node-negative cancers, which represent the largest patient subgroup of early-stage breast cancers in first-world countries. The investigators plan to continue monitoring patients for a median follow-up of 20 years.
Irradiation of regional nodes in patients with stage I-III breast cancer has a minimal effect on overall survival.
- Acupuncture an Effective Alternative Treatment for Cancer-Related Fatigue
- Response to Anemia Treatment Differs in Lymphoma, Multiple Myeloma
- Compound in Teas, Peas, Soybeans May Increases Prostate Cancer Risk
- Fertility Preservation in Male Adolescents and Young Adults With Cancer
- Social, Psychiatric Variables Reduce Cognitive Functioning, QoL in HNC
- HPV and Cancer (Fact Sheet)
- Pain Control More Easily Achieved With Nurse-Led Education in Bone Metastases
- Using Nutrition-Based Strategies to Manage Adverse Effects of Cancer
- Palliative Care Associated With Decreased Costs For Patients With Advanced Cancer
- A Case of Immunotherapy-Induced Myocarditis Concomitant to MG in Lung Cancer
- Online Learning Modules Improve Exercise Counseling, But Not Participation
- ASCO Issues Statement Addressing Alcohol and Cancer
- Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer
- Axillary Lymph Node Dissection Predictive for Lymphedema in Breast Cancer
- Drug Combination Does Not Extend Glioblastoma Survival
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|