EPO plus radiotherapy does not improve local-regional control in anemic patients with head and neck cancer
the ONA take:
According to a long-term analysis of a study originally published in 2007, researchers have found that the combination of erythropoietin and radiation therapy did not improve local-regional control for anemic patients with head and neck squamous cell carcinoma who receive radiotherapy or chemoradiotherapy.
The 2007 Radiation Therapy Oncology Group (RTOG) 9903 study was an open-label, randomized, phase III trial that evaluated whether the addition of erythropoietin to radiotherapy would improve disease control in anemia patients with head and neck squamous cell carcinoma.
For this long-term analysis, results showed that the local-regional failure rate was 39.4% for patients who received radiotherapy or chemoradiotherapy without erythropoietin compared with 46.2% for patients who received erythropoietin at 5-year follow-up (HR = 1.40). Researchers found no statistically significant differences in 5-year progression-free survival, overall survival, or 5-year distant metastases rate between the two groups.
The findings suggest that erythropoietin should not be utilized in anemic patients with head and neck squamous cell carcinoma.
Combination erythropoietin and radiation therapy did not improve control for anemic patients with head and neck squamous cell carcinoma.
- Acupuncture Improves Postoperative Symptoms in Women Undergoing Surgery for Breast Cancer
- Prehabilitation Program Improves Preoperative Fitness in Patients With Colorectal Cancer
- Alcohol Consumption, Particularly White Wine, Associated With Increased Risk of Melanoma
- Combination of Gemcitabine and New CHK1 Inhibitor Is Effective in Soft Tissue Sarcomas
- Omitting RT in Certain Older Women With Early Breast Cancer is Safe
- Walnut Consumption Changes Gut Microbiome, Decreases Growth of Colon Cancer in Mice
- Vaccine Enters Phase I Study for Safety and Effectiveness in Multiple Myeloma
- Timing Chemotherapy Administration to Circadian Rhythm Improves Drug Effectiveness
- New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases
- Baseline PSA Levels in Midlife Could Predict Risk of Lethal Prostate Cancer
- Community Breast Navigation Program Improved Breast Screening Rates in Underserved African American and Latino Women
- Live-streamed Videos Address End-of-Life Planning, Decision-making
- Metastatic Disease Linked to Patients Reporting Diminished QoL
- History of Bilateral Salpingo-oophorectomy, Hormone Replacement Therapy Are Predictive of Breast Density at Cancer Diagnosis
- Mammographically Occult Contralateral Breast Cancer Detection is Effective With Preoperative MRI
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|