Five New Genetic Variants Linked With Glioma Identified

the ONA take:

Five new genetic variants associated with glioma have been identified in the biggest ever study of DNA in patients within this population, according to a study published in Nature Communications.

Richard Houlston, MD, PhD, of The Institute of Cancer Research and an international team analyzed DNA from more than 5,637 patients with glioma from Europe, the United States, and Canada, and compared them with 9,158 patients without the disease.

Each variant they found was a one-letter difference in the DNA code that was associated with an increased risk of glioma in those who have it, thus bringing the total number of genetic variants linked to glioma to 12.

One variant in particular was linked with a 23% increased risk of glioblastoma, an aggressive form of glioma with an average survival of 10 to 15 months after diagnosis.

“We believe our study is the largest ever conducted of the genetics of glioma – the most common form of brain cancer – and it provides firm evidence that susceptibility to the disease is in part inherited,” Houlston said.

Five New Genetic Variants Linked With Glioma Identified
Five new genetic variants associated with glioma have been identified in the biggest ever study of DNA in patients within this population.
The biggest ever study of DNA from people with glioma - the most common form of brain cancer - has discovered five new genetic variants associated with the disease. One variant increases the risk of developing glioblastoma, a particularly aggressive kind of glioma with an average survival of only 10-15 months after diagnosis, by almost a quarter.
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