Tetanus primer significantly improves survival after immunotherapy for glioblastoma
the ONA take:
A study led by Duke Cancer Institute researchers demonstrated that an innovative pretreatment can enhance the effectiveness of immunotherapy for glioblastoma, dramatically improving patient survival.
Earlier research findings showed that glioblastoma tumors harbor a strain of cytomegalovirus (CMV) not present in the brain tissue around the tumor. This provides a natural target for immunotherapy.
Using dendritic cells, the researchers created a vaccine for the tumor. Patients with glioblastoma typically survive for little more than 1 year after diagnosis; however, after receiving the immunotherapy, half lived nearly 5 years or longer from their diagnosis.
Looking to expand on the effectiveness of the treatment, the researchers chose to use a shot of tetanus/diphtheria toxoid to incite the patient’s immune system.
In a blinded trial involving 12 patients with brain tumor, half were randomly selected to receive the tetanus shot; the other half received a placebo injection. The patients who received the tetanus shot had significantly longer survival than those who received the dendritic cell therapy alone (51-101 months vs 11.6 months).
One patient in the tetanus group continues to show no tumor growth and is still alive 8 years after the treatment.
An innovative pretreatment can enhance the effectiveness of immunotherapy for glioblastoma, dramatically improving patient survival.
- Study Identifies Factors Associated With Hearing Loss in Polycythemia Vera
- Ezh2 Inhibitors May Offer Cure for Chronic Myelogenous Leukemia
- Ruxolitinib: A Targeted Treatment Option for Patients with Polycythemia Vera
- Incontinence Affects QOL for Survivors of Gynecologic Cancers
- Robotic Surgery Provides Good Outcomes and Survival in Oropharyngeal Cancer
- Overall Benefits of Vaporized Nicotine Products Outweigh Harms, Says International Panel of Experts
- Sugar and Cancer: Mitigating the Affects of Diet on Cancer
- Nurse Residency Programs Can Impact Oncology Nursing Practice, Outcomes
- Tumor Markers (Fact Sheet)
- Implementing a Distress Screening Process for Cancer Patients
- Ruxolitinib Effective as Long-term Treatment Option for Polycythemia Vera
- Definitive IMRT Associated With Shorter Feeding Tube Placement Duration in HNC
- SBRT Improves Overall and Disease-Specific Survival in Stage I NSCLC
- Patients Receiving RT in APBI Facilities Despite Eligibility for Observation
- Prolonged Imatinib Therapy Improves Likelihood of Deeper Molecular Response
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|