Genetic variations associated with cisplatin-induced ototoxicity identified
the ONA take:
The anti-cancer drug cisplatin is widely administered to treat brain cancer and other tumors, but some individuals treated with cisplatin experience severe hearing loss, among other side effects.
But the effect of patients varies widely. The reasons why some patients were affected has not been fully understood, but a group of investigators based at St. Jude Children's Research Hospital feel the cause of rooted in genetic variations.
The research team examined DNA from 238 patients with brain tumors and took into account some 1.7 million common genetic variations, looking for a link to the cisplatin-related hearing loss. This was the first time a possible genetic cause of this side effect had been investigated.
The result: genetic variations in a gene called ACYP2 were linked to as much as a four-fold increase of risk for hearing loss. This association was verified in a separate group of 68 patients after other risk factors, such as radiation treatment or age, were eliminated. Individuals with at least one copy of the ACYP2 variant experienced hearing loss, establishing a link to that genetic variation, but additional individuals also experienced hearing loss so the researchers feel other, not-yet-identified genetic variations are also at play.
This research could be the first step in identified patients receiving cisplatin that are at high risk of hearing loss. Additional research into why the ACYP2 variations actually trigger the hearing is needed.
The anti-cancer drug cisplatin is widely administered to treat brain cancer and other tumors.
- Short-Term Intervention May Have Long-term Diet Effect in Hispanic Breast Cancer Survivors
- Childhood Cancer Linked to Poor Diet Quality in Adult Survivors
- Low-Dose Sublingual Fentanyl Safe, Effective in Patients Receiving Lower Opioid Doses
- Atezolizumab Granted FDA Approval for Specific Cases of NSCLC
- New Research Identifies Potential Bladder Cancer Chemotherapy Side Effect
- Overall Benefits of Vaporized Nicotine Products Outweigh Harms, Says International Panel of Experts
- Sugar and Cancer: Mitigating the Affects of Diet on Cancer
- Nurse Residency Programs Can Impact Oncology Nursing Practice, Outcomes
- Implementing a Distress Screening Process for Cancer Patients
- Initiating Palliative Care in the Emergency Department
- HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC
- More Than Half of Melanomas Are Self-Detected, Especially by Women
- Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer
- Smoking-related Cancer Deaths Highest in Southern United States
- Study Suggests More Men With Prostate Cancer Would Choose Active Surveillance if it Were Offered
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|