Insufficient fluconazole levels in pediatric patients with cancer treated for invasive candidiasis
the ONA take:
According to a new study published in the journal Clinical Infectious Diseases, researchers have found that the fluconazole concentration in pediatric patients with cancer and invasive candidiasis is not sufficient for treatment with the currently recommended dosing regimen.
For the study, researchers identified 99 critically ill pediatric patients treated with fluconazole from January 2007 to October 2013. Of the 99 patients, 40% had subtherapeutic fluconazole plasma concentrations. Analyses demonstrated a significant and positive association between fluconazole trough concentration and dose (P < 0.001), weight (P = 0.009) and the serum urea concentration (P = 0.003).
In addition, there was a significant and negative association between fluconazole trough concentration and age (P = 0.004) and cancer as the underlying cause of invasive candidiasis (P = 0.003). In addition, they found that a higher fluconazole trough concentration was linked with a decreased duration to culture conversion (HR = 1.076, 95% CI 1.017 - 1.138, P = 0.011).
The findings suggest that a higher dose of fluconazole is necessary to achieve sufficient drug concentrations for the treatment of invasive candidiasis in critically ill pediatric patients with cancer.
Fluconazole in pediatric patients with cancer and invasive candidiasis is not sufficient for treatment.
- Study Identifies Factors Associated With Hearing Loss in Polycythemia Vera
- High Symptom Burden With Polycythemia Vera Linked to QoL Impairment
- Bioimpedence Spectroscopy Improves Early Detection of Breast Cancer-Related Lymphedema in At-Risk Patients
- Ezh2 Inhibitors May Offer Cure for Chronic Myelogenous Leukemia
- MRD Negativity Associated With Prolonged Survival in Myeloma
- Overall Benefits of Vaporized Nicotine Products Outweigh Harms, Says International Panel of Experts
- Sugar and Cancer: Mitigating the Affects of Diet on Cancer
- Nurse Residency Programs Can Impact Oncology Nursing Practice, Outcomes
- Tumor Markers (Fact Sheet)
- Implementing a Distress Screening Process for Cancer Patients
- ASCO, ASTRO Issue Guideline Update for Postmastectomy RT
- Study Assesses Efficacy of Ramucirumab in HCC by Child-Pugh Score
- Incontinence Affects QOL for Survivors of Gynecologic Cancers
- Patient Navigation Reduces Delays in Diagnostic Resolution
- Fee-for-service Medicare Plans Linked to Improved Care During Last Year of Life
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|