PARP inhibitors plus chemotherapy may be effective for Ewing sarcoma
the ONA take:
According to a new study published in the journal Cell Reports, researchers at St. Jude Children's Research Hospital in Memphis, Tennessee, have found that a combination of experimental drugs caused Ewing sarcoma tumors to disappear in mice, and those tumors did not return in more than 70% of those mice.
For the study, the researchers treated mice with Ewing sarcoma with poly-ADP ribose polymerase (PARP) inhibitors in addition to chemotherapy. PARP inhibitors work by interfering with DNA repair, thereby causing cancer cell death.
Mice were treated with irinotecan, temozolomide, and one of three PARP inhibitors currently in development for pediatric cancer treatment. The researchers found that Ewing sarcoma disappeared and not relapsed in over 4 months in about 70% of mice treated with irinotecan, temozolomide, and olaparib. Olaparib is an investigational PARP inhibitor currently being studied for the treatment of breast and ovarian cancers. Mice treated with the same chemotherapy plus talazoparib, another PARP inhibitor, achieved a complete remission rate of 88%.
The researchers plan to conduct clinical trials testing irinotecan and talazoparib in patients age 1 and older and the three-drug combination therapy in patients age 16 and older with Ewing sarcoma.
A combination of experimental drugs caused Ewing sarcoma tumors to disappear in mice.
Ewing sarcoma tumors disappeared and did not return in more than 70 percent of mice treated with combination therapy that included drugs from a family of experimental agents developed to fight breast cancer, reported St. Jude Children's Research Hospital scientists. The study will appear in the November 6 edition of the scientific journal Cell Reports.
The treatment paired two chemotherapy drugs currently used to treat Ewing sarcoma (EWS) with experimental drugs called poly-ADP ribose polymerase (PARP) inhibitors that interfere with DNA repair. PARP inhibitors are currently in clinical trials for the treatment of certain breast and ovarian cancers as well as other solid tumors. EWS is a cancer of the bone and soft tissue that strikes primarily adolescents and young adults.
- Osteoporosis Medication Improves Bone Health in ADT-Treated Prostate Cancer
- Inotuzumab Ozogamicin Granted FDA Approval for Acute Lymphoblastic Leukemia
- Cabazitaxel in Prostate Cancer: Reduced Dose Noninferior to Standard Dose
- Risk of Some Cancers Higher in Women With a History of Periodontal Disease
- Breast Conservation Improves Survival vs Mastectomy in Breast Cancer
- To Better Serve Patients With Cancer, Navigators Need Better Systems
- Physical Activity Improves Cognitive Function for Breast Cancer Survivors
- Risk of Lung Cancer Increases With Diets Higher in Saturated Fats
- Mechanisms Identified for Curcumin Resensitization of Cancer Cells
- Value of Type and Crossmatch Prior to Daratumumab Administration
- Affect of Daratumumab on Laboratory Blood Test Results
- Geriatric Consults Rare in Kidney Cancer Care
- Worse Survival Seen for Alternative Versus Usual Cancer Therapy
- Anorexia-Cachexia in Non-Small Cell Lung Cancer Improved With Anamorelin
- Early Recognition of Checkpoint Inhibitor-Related Pneumonitis Improves Outcomes
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|