CTCs can be captured and cultured for genetic analysis and drug testing of breast cancer cells

the ONA take:

A microchip-based device developed at the Massachusetts General Hospital (MGH) Center for Engineering in Medicine and the MGH Cancer Center can capture circulating tumor cells (CTCs). The CTCs can then be cultured to establish cell lines for genetic analysis and drug testing. Circulating tumor cells are cells that break off a primary or metastatic tumor and travel through the bloodstream in small quantities. The device, called the CTC-iChip, captures the CTCs in a way that enables accurate determination of the genetic status of a tumor. In the study, researchers isolated CTCs from the blood of 36 patients with metastatic, estrogen-receptor positive breast cancer. The test confirmed mutations identified in the primary tumor as well as identified new mutations not present in the primary tumor. Testing the CTC lines for drug sensitivity also identified potential combinations that inhibited cell growth in mouse tumors developed from injection of CTCs from the patients. The researchers hypothesize that this approach may have a significant impact on individually adjusted cancer therapy in the future.

CTCs can be captured and cultured for genetic analysis and drug testing of breast cancer cells
CTCs can be captured and cultured for genetic analysis and drug testing of breast cancer cells
Circulating tumor cells captured with a microchip-based device developed at the Massachusetts General Hospital (MGH) Center for Engineering in Medicine and the MGH Cancer Center can be cultured to establish cell lines for genetic analysis and drug testing. In the July 11 issue of Science, an MGH research team reports that the cultured cells accurately reflect a tumor's genetic mutation over time and changing susceptibility to therapeutic drugs.
READ FULL ARTICLE From Science Codex
Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs