Combined use of painkillers, antidepressants may increase bleeding risk

the ONA take:

According to a study published this week in The BMJ, researchers have found that combined use of antidepressants and NSAID painkillers is associated with an increased risk of bleeding.

For the study, researchers analyzed data from more than 4 million people who were prescribed antidepressants between 2009 and 2013 included in the Korean nationwide health insurance database. Researchers compared the time to first admission with intracranial hemorrhage within 30 days of a new prescription among patients with antidepressants and NSAIDs compared with those with only antidepressants.

Results showed a substantially increased bleeding risk among those who took both prescription medications. Moreover, there was no statistically significant difference in risk of bleeding with age or different classes of antidepressant medications. Male gender was also found to be associated with a higher risk of bleeding among those who were prescribed the combination.

The authors note that their results may have been impacted by other factors and caution is advised when interpreting the results; however, health care professionals should use caution in patients who are prescribed both types of medications.

NSAIDs linked to decreased breast cancer recurrence among obese women
Researchers have found that combined use of antidepressants and NSAID painkillers is associated with an increased risk of bleeding.
Taking a combination of antidepressants and common painkillers is associated with an increased risk of bleeding soon after starting treatment, finds a study published in The BMJ this week.
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