Chemo testicular nonseminoma may increase risk of short-term CVD death

the ONA take:

Patients with testicular nonseminoma have significantly increased cardiovascular disease mortality after chemotherapy but not surgery, a new study published online ahead of print in the Journal of Clinical Oncology has shown.

Previous research from the 1960s has shown that long-term survivors of testicular cancer who were treated with chemotherapy have increased risks of incidence cardiovascular disease, but there is a lack of data on whether treatment increases cardiovascular mortality during, shortly after, and for two decades after diagnosis in a time where most patients with testicular cancer receive cisplatin-based regimens.

For the study, researchers analyzed data from 15,006 patients with testicular nonseminoma from the Surveillance, Epidemiology, and End Results (SEER) database. Of those, 6,909 initially received chemotherapy and 8,097 initially underwent surgery without radiation.

Results showed that cardiovascular disease mortality was significantly increased after chemotherapy but not surgery. Researchers found that increased cardiovascular disease mortality was limited to the first year after testicular cancer diagnosis.

The authors conclude that the increased short-term risk of cardiovascular disease death should be investigated further in analytic studies.

Patients with advanced ovarian cancer benefit more from chemo before surgery
Patients with testicular nonseminoma have significantly increased cardiovascular disease mortality after chemotherapy.
Few population-based investigations have quantified CVD mortality during, shortly after, and for two decades after TC diagnosis in the era of cisplatin-based chemotherapy.
READ FULL ARTICLE From Ascopubs
Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs