Can docetaxel cause intoxication in cancer patients?

the ONA take:

A recent food and Drug Administartion (FDA) alert has linked the chemotherapeutic drug, docetaxel, to intoxication effects in some patients. The number of reports of this effect have been limited, but the FDA is requiring drug manufacturers that sell docetaxel to label for the presence of ethyl alcohol.

Docetaxel contains 18% alcohol by weight, or an alcohol volume similar to port wine, but because intravenous chemotherapy drugs are typically dosed based on a patient’s body surface area, not their weight, the actual amount of alcohol delivered to a patient can be difficult to determine. The actual amount of alcohol a patient receives would most likely be small, but the impact of the ethyl alcohol with common sedation effects produced by other pre-medication, such as anti-nausea drugs or pain relievers, should be considered, as should the effects on elderly patients with cancer. 

The FDA has recommended that clinicians observe a number of cautions, including: taking into account docetaxel's alcohol content for patient's with other mitigating factors or hepatic impairment; limiting a patient's use of vehicles or heavy machinery for up to 2 hours after administration; and providing counseling for patients or slowing the rate of administration as a precautionary measure.

Can docetaxel cause intoxication in cancer patients?
Can docetaxel cause intoxication in cancer patients?
The FDA issued an alert last Friday that some patients have reported feeling intoxicated after receiving their infusions of the chemotherapeutic drug, docetaxel. The agency will be requiring companies manufacturing docetaxel to more prominently label that the drug solution contains the alcohol found in recreational beverages, known more precisely as ethyl alcohol (or ethanol).
READ FULL ARTICLE From Forbes
Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs