Low 21-gene expression score associated with low risk of breast cancer recurrence

the ONA take:

Patients with hormone receptor-positive, HER2-negative, axillary node-negative breast cancer and a favorable 21-gene expression assay score had very low rates of disease recurrence at 5 years with endocrine therapy alone, initial results of the TAILORx study published online ahead of print in The New England Journal of Medicine have shown.

For the study, 10,253 eligible women with breast cancer were enrolled. Of those, 1,626 women had a recurrence score of 0 to 10 who were assigned to receive endocrine therapy alone without chemotherapy.

Results showed that 5-year invasive disease-free survival rate was 93.8% (95% CI: 92.4, 94.9), the rate of freedom from recurrence of breast cancer at a distant site was 99.3% (95% CI: 98.7, 99.6), and the rate of freedom from recurrence at a distant or local-regional site was 98.7%. Researchers found that the overall survival rate was 98.0% (95% CI: 97.1, 98.6).

"The compelling results seen in this global study provide unequivocal evidence supporting the clinical utility of Oncotype DX to risk-stratify patients with early stage breast cancer, and indicate that the findings are generalizable to everyday clinical practice," said lead author Joseph A. Sparano, MD, vice-chairman of medical oncology at Montefiore Einstein Center for Cancer Care, and professor of medicine and of obstetrics, gynecology, women's health at Albert Einstein College of Medicine.

Low 21-gene expression score associated with low risk of breast cancer recurrence
Patients with HER2-negative, axillary node-negative breast cancer and favorable 21-gene expression assay score had low rates of recurrence.
Initial results were announced today from the Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, a multi-center prospectively conducted trial of more than 10,000 women with early stage breast cancer sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) with support from Genomic Health, Inc.
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