Bisphosphonates May Be Useful as Palliative Measure in Selected Patients
the ONA take:
Bisphosphonates may improve symptoms of hypercalcemia and prolong survival in patients with malignancy-associated hypercalcemia receiving palliative care, a new study published online ahead of print in the journal Supportive Care in Cancer has shown.
Because hypercalcemia can be a potentially fatal paraneoplastic complication of malignancy, researchers sought to determine the reversibility of hypercalcemia amongst patients not receiving treatment for their underlying malignancy and assess whether calcium correction improves symptoms.
For the study, researchers analyzed data from 63 patients with evidence of malignancy-associated hypercalcemia being treated with bisphosphonates. Results showed that 36 of the 63 participants achieved normal calcium levels following treatment with an intravenous bisphosphonate.
Researchers found that history of hypercalcemia in the past, age, and albumin levels impacted whether patients achieved a complete response. The study also demonstrated that a reduction in calcium level was associated with significantly improved survival and symptoms regardless of whether patients achieved normal calcium levels.
Malignancy-associated hypercalcemia typically manifests during the advanced phase of cancer, when the life expectancy of patients ranges from weeks to months.
Although bisphosphonates are the mainstay of treatment for this complication, they are not typically used in a palliative population.
Bisphosphonates may improve symptoms of hypercalcemia and prolong survival in patients receiving palliative care.
- Ixazomib, a New PI, Offers Improved Efficacy With Acceptable Toxicity Profile for Relapsed/Refractory Multiple Myeloma
- Acupuncture May Improve Fatigue in Patients with Lung Cancer
- "Light" Cigarettes and Cancer Risk (Fact Sheet)
- A Review of CDK4/6 Toxicities and Interactions Management in Breast Cancer
- Vitamin D3 Supplementation Has No Impact on Breast Density Percentage, Breast Cancer Risk
- Dexamethasone-Induced Hiccups in Chemotherapy May be Prevented by Rotating to Methylprednisolone
- New Evidence Shows Metastases May Spread Independently of Lymph Nodes
- Long Term Survivors of Prostate Cancer Express Treatment Decision Regret for Up to 15 Years
- FDA Expands Clearance for Cooling Cap Use With Chemotherapy for Solid Tumors
- Recommendations for Vaccine Administration During Chemotherapy
- Risk for Prostate Cancer Not Associated With Vasectomy, Meta-analysis Affirms
- Disease-Free Survival After Breast Cancer Comparable With Exemestane, Sequential Tamoxifen/Exemestane
- Treating the Other "Patient": Depressive Symptoms Are Predictive of Declining Physical Health in Caregivers
- Oropharyngeal Mucositis Pain Effectively Relieved With Indomethacin Oral Spray
- Opioids Overprescribed in Patients Undergoing Surgery
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|