Aspirin and/or NSAID use may improve risk of high-grade prostate cancer

the ONA take:

A recent meta-analysis demonstrated an association between aspirin and a reduced risk of prostate cancer. Anti-inflammatory medications lower prostate-specific antigen (PSA) levels; therefore, whether these findings reflect reduced prostate cancer detection or lower risk of the disease is not known. The researchers tested the association between aspirin and non-aspirin nonsteroidal anti-inflammatory drug (NSAID) on prostate cancer diagnosis in the REDUCE trial, where all men underwent biopsy at 2- and 4-years largely independent of PSA. The researchers examined the association between aspirin, NSAID, or both and total, low-grade (Gleason <7) prostate cancer, or high-grade (Gleason ≥7) prostate cancer vs. no prostate cancer using multinomial logistic regression among 6,390 men who underwent on-study biopsy one or more times. Overall, 50% of the men were nonusers, 21% used aspirin, 18% used NSAIDs, and 11% of the men used both. In unadjusted models, aspirin was associated with reduced risk of prostate cancer. In multivariable analyses, aspirin was associated with reduced total prostate cancer risk, but use of NSAID or NSAIDs and aspirin was not associated with reduced risk of prostate cancer. Therefore, we created a dichotomous variable of aspirin and/or NSAID user vs. not. On multivariable analysis, the use of aspirin and/or NSAID was significantly associated with decreased total and high-grade prostate cancer risk, but not with risk in low-grade prostate cancer.

Aspirin and/or NSAID use may improve risk of high-grade prostate cancer
Aspirin and/or NSAID use may improve risk of high-grade prostate cancer
The authors tested the association between aspirin and non–aspirin NSAID on prostate cancer (PC) diagnosis in REDUCE, where all men received biopsies at 2– and 4–years largely independent of PSA.
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