Patients with advanced ovarian cancer benefit more from chemo before surgery

the ONA take:

According to a new study published today in the journal The Lancet, researchers from Cancer Research UK have found that women with advanced ovarian cancer tend to have a better quality of life and fewer adverse events if given chemotherapy before surgery rather than chemotherapy afterwards.

For the non-inferiority, controlled, phase III CHORUS trial, researchers enrolled 550 women with advanced ovarian cancer and randomly assigned them 1:1 to either undergo primary surgery followed by six cycles of chemotherapy, or to three cycles of primary chemotherapy, then surgery, followed by three more cycles of chemotherapy.

Results showed that median overall survival was 22.6 months in the primary-surgery group compared with 24.1 months in the primary-chemotherapy arm.

In regard to safety, grade 3-4 postoperative adverse events and deaths within 28 days after surgery occurred more often in the primary-surgery group than in the primary-chemotherapy group (24% vs 14%; P = 0.0007, and 6% vs <1%; P = 0.001).

The findings suggest that both approaches are viable options for women with stage III or IV ovarian cancer.

Patients with advanced ovarian cancer benefit more from chemo before surgery
Patients with advanced ovarian cancer benefit more from chemo before surgery
Women with advanced ovarian cancer have fewer side effects and tend to have a better quality of life if given chemotherapy before surgery, according to a Cancer Research UK study published today (Wednesday) in The Lancet.
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