Adult survivors of pediatric cancer who underwent brain irradiation at risk for hormone deficiencies
the ONA take:
According to a new study published in the Journal of Clinical Oncology, researchers at St. Jude Children's Research Hospital in Memphis, Tennessee, have found that adult survivors of pediatric cancer are at risk for developing pituitary hormone deficiencies that may worsen their health and quality of life.
For the study, researchers analyzed data from 748 adults survivors of pediatric leukemia, brain, and other cancers that had received brain irradiation as part of their treatment in order to determine the long-term effect of the treatment on function of the pituitary gland.
Results showed that 51.4% of adult survivors were deficient in at least one of the hormones studied and 10.9% of survivors had multiple hormone deficiencies. The most common hormone deficiency involved gonadotropins, which play a role in fertility and reproduction.
Researchers also found that patients with those hormone deficiencies were more likely to be undiagnosed, and those were untreated were more likely to experience poor fitness, muscle weakness, heart disease risk factors, and other factors linked with an elevated risk of frailty and decreased mortality.
The authors note that additional research is warranted to to help manage patients with growth hormone deficiency.
Adult survivors of pediatric cancer are at risk for developing pituitary hormone deficiencies that may worsen their health and quality of life.
- Physical Activity Improves Outcomes for Patients with Breast Cancer and Survivors
- Behavior Pain Assessment Tool Measures Pain In Patients Who Cannot Communicate Verbally
- Whole Genome Sequencing Reveals that 12% of Childhood Cancer Survivors Have Mutations in Genes that Increase Cancer Risk
- Novel Test For Multiple Myeloma Uses Microchip, Conventional Blood Sample
- Increased 5-Year Survival Rate Seen in NSCLC Subset Treated With Nivolumab
- Exercise, Psychological Interventions Better for Cancer Fatigue Than Medications
- ASCO Issues Global Guidance for HPV Vaccination for Cervical Cancer Prevention
- Discharge Events Improved With Standardized Inpatient Palliative Care Consultation
- Little Opposition to Early Palliative Care for Symptom Management in Pediatric Oncology
- Updated ASTRO Guideline Bolsters Safety, Efficacy of Palliative RT for Bone Metastases
- Thyroid Cancer Incidence Increasing Among Younger, Hispanic, African American Populations
- JAK1, JAK2 Inhibition Improves Outcomes in Myeloproliferative Neoplasms, But More Is Needed
- Recommendations Against Contralateral Prophylactic Mastectomy Not Tied to Patient Satisfaction
- Self-efficacy Level Predictive of Likelihood to Follow Through With Colorectal Cancer Screening
- Chronic Myeloproliferative Neoplasms Treatment (Fact Sheet)
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|