Gynecologic Cancer

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

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The benefits of primary cytoreductive surgery relative to neoadjuvant chemotherapy remain uncertain; therefore, researchers performed a retrospective data analysis to compare overall survival of surgery with that of neoadjuvant chemotherapy in advanced-stage epithelial ovarian cancer.

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

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Researchers report on the feasibility of a nurse-led sexual rehabilitation intervention to target sexual recovery and vaginal dilation in women who underwent pelvic radiation therapy and brachytherapy for gynecologic cancers.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

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Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

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Rapid, robust, and affordable genetic testing for patients with ovarian cancer that allows a much larger portion of patients to benefit from personalized cancer management and their relatives to benefit from preventive strategies can be achieved.

Socioeconomic Status Inversely Related to Risk for Ovarian Cancer in African American Women

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Risk of ovarian cancer is higher in African American women with lower socioeconomic status, the opposite of trends seen in breast cancer.

Routine Pap Smears Improve Cervical Cancer Risk in Women Older Than 65 Years

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Despite confirmation of a link between routine Pap smear screening and a lower risk of developing cervical cancer in women older than 65 years, most US health guidelines discourage older women from undergoing routine Pap smears unless they have pre-existing risk factors.

Prophylactic Gynecologic Resections Increase Risk for Aggressive Uterine Cancer in BRCA Gene Mutation Carriers

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Women who carry the BRCA1 mutation are at increased risk for serous/serous-like endometrial carcinoma after risk-reducing salpingo-oophorectomy. Yet uncertainty exists over the need to perform a full hysterectomy in these women.

HPV Vaccination Program Reduces Cervical Cell Anomalies in Young Women

HPV Vaccination Program Reduces Cervical Cell Anomalies in Young Women

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Fewer cervical cell anomalies were present on cervical cancer screens of young women in Canada who received the HPV vaccine through a school-based program.

Adjuvant CRT Feasible for High-risk Endometrial Cancer

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Adjuvant chemotherapy administered during and after radiotherapy is feasible for the treatment of patients with high-risk endometrial cancer despite an increased risk of toxicities compared with radiotherapy alone.

Imaging and Fluorescence Technique Guides Surgical Removal of Otherwise Undetectable Ovarian Tumors

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A newly created tumor-specific fluorescent molecule combined with an imaging system guided surgeons to removing additional tumors not palpable or visible without fluorescence in patients with ovarian cancer.

Chemotherapy Boosts Effectiveness of Immunotherapy in the Treatment of Ovarian Cancer

Chemotherapy Boosts Effectiveness of Immunotherapy in the Treatment of Ovarian Cancer

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Immunotherapy for advanced ovarian cancer more effectively treats tumors when administered immediately after chemotherapy. Sequential chemoimmunotherapy could improve disease control in stage IIIC/IV tubo-ovarian HGSC.

Number of Ovarian Cancer Cases Not Treated Surgically or Not Treated at All Is Increasing

Number of Ovarian Cancer Cases Not Treated Surgically or Not Treated at All Is Increasing

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The number of patients older than 75 years who do not undergo surgery is increasing, especially among those with stage III or IV ovarian cancer. Approximately 50% do not undergo surgery and 25% receive no treatment at all.

Genetic Subtypes of HLA Are Linked to Increased Overall Risk of Ovarian Cancer

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Overall risk of developing ovarian cancer may be higher for women with certain types of human leukocyte antigen (HLA), which could underlie differences in their response to immunotherapy.

Cell Changes in Fallopian Tubes of BRCA Mutation Carriers May Lead to Strategies for Preventing Ovarian Cancer

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Recognition of early changes in the Fallopian tube cells of BRCA gene mutation carriers may be key to new strategies for preventing ovarian cancer that could also reduce the need for invasive surgery.

ASCO Releases Resource-Stratified Guidelines for Management of Invasive Cervical Cancer

ASCO Releases Resource-Stratified Guidelines for Management of Invasive Cervical Cancer

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ASCO has published its first clinical practice guideline on invasive cervical cancer, and the guidelines are the first to offer treatment recommendations tailored to resource availability.

T Cells Have the Potential to Reverse Chemotherapy Resistance in Patients With Ovarian Cancer

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A new perspective on chemotherapy resistance in ovarian cancer may be a step toward overcoming that resistance. Fibroblasts block chemotherapy, leading to chemotherapy resistance; however, immune system T cells can reverse that resistance.

No Clinical Benefit to Expanding Gene Panel Beyond Ovarian and Breast Cancer Genes in High-risk Women

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Expanding a panel of tested genes beyond the known breast and ovarian cancer-specific genes in patients with breast and ovarian cancer did not confer any clinical benefit.

Obesity Can Mask Ovarian Cancer Symptoms in African American Women

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Excess abdominal fat in overweight and obese women could interfere with detection of early symptoms of ovarian cancer, and this may contribute to the higher risk of death from ovarian cancer in African American women compared with white women.

Nuclear Imaging Offers Noninvasive Assessment of Early Stage Cervical Cancer

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In patients with cervical cancer who do not have enlarged lymph nodes, SPECT-MRI imaging of their sentinel lymph nodes (SLNs) could assess whether metastases are present.

Telephone Follow-Up Effective for Stage I Endometrial Cancer

Telephone Follow-Up Effective for Stage I Endometrial Cancer

Nurse-based telephone follow-up was as effective as traditional hospital based follow-up for for stage I endometrial cancer.

Mastectomy Increases Life Expectancy in Younger Women With Ovarian Cancer

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Risk-reducing mastectomy (RRM) can increase life expectancy and be cost effective in women up to age 60 years with ovarian cancer as carriers of a BRCA mutation.

Immune Therapy Drug Shows Early Promise in Subtype of Endometrial Uterine Cancer

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In a small group of women with mismatch repair (MMR) deficiency endometrial uterine cancer, survival was increased by pembrolizumab.

Hormone Replacement Therapy Improves Bone Mineral Loss After Salpingo-oophorectomy for Ovarian Cancer

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In patients who undergo risk-reducing salpingo-oophorectomy, BMD screenings are underutilized in spite of the prevalence of bone mineral loss in this population. Hormone replacement therapy can address BMD loss in these women.

Progression-free and Overall Survival Better With Mutations Affecting DNA Repair Genes in Ovarian Cancer

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Women with advanced ovarian cancer who had mutations affecting DNA repair genes had longer progression-free and overall survival than women without the mutations.

Farletuzumab Fails to Improve Survival in Ovarian Cancer

Farletuzumab Fails to Improve Survival in Ovarian Cancer

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Adding farletuzumab to carboplatin and a taxane failed to improve progression-free survival in patients with platinum-sensitive ovarian cancer.

Researchers Identify Tumor Signature That Serves as a Biomarker of at Least 5 Types of Cancer

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A methylation signature was identified in 5 types of cancer, and it likely occurs in more. These findings may aid in developing a blood test to diagnose cancer at early stages, when it is most treatable.

Incidence of Undetected Cancer in Patients Undergoing Gynecologic Surgery for a Benign Condition Higher Than Estimated

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Researchers in Massachusetts sought to determine how frequently cancer is diagnosed in women after undergoing gynecologic surgery for a problem believed to be benign.

Venlafaxine May Have Activity in Taxane-, Oxaliplatin-Induced Acute Neurotoxicity

Venlafaxine May Have Activity in Taxane-, Oxaliplatin-Induced Acute Neurotoxicity

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Venlafaxine has a significant clinical activity against taxane-oxaliplatin-induced acute neurosensory toxicity in patients with cancer.

Timing of Chemotherapy Initiation May Affect Advanced Ovarian Cancer Survival

Timing of Chemotherapy Initiation May Affect Advanced Ovarian Cancer Survival

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Survival for women with advanced ovarian cancer may be negatively impacted when chemotherapy is initiated more than 25 days after surgery.

Hormone replacement therapy safe, may be beneficial for women treated for ovarian cancer

Hormone replacement therapy safe, may be beneficial for women treated for ovarian cancer

Women with epithelial ovarian cancer, the most common type, can safely take hormone replacement therapy (HRT).

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