Gynecologic Cancer

Quarterly Testing for Biomarker Improves Detection of Early-Stage Ovarian Cancer in High-Risk Women

Quarterly Testing for Biomarker Improves Detection of Early-Stage Ovarian Cancer in High-Risk Women

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A protocol of testing of CA125 levels quarterly with subsequent transvaginal ultrasound examination increased detection of early-stage ovarian cancer in women at high-risk for the disease.

Screening Increases Early Palliative Care, Reduces Aggressive EOL Measures

Screening Increases Early Palliative Care, Reduces Aggressive EOL Measures

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Universal screening of women with gynecologic malignancies for early palliative care decreased the use of aggressive measures at the end of life.

Endometrial Cancer Survivors in High-Poverty Areas Have Impaired Access to Self-Care Resources

Endometrial Cancer Survivors in High-Poverty Areas Have Impaired Access to Self-Care Resources

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Living in a high-poverty region is associated with lower access to obesity-related self-care resources.

Priority Symptoms Identified in Recurrent Ovarian Cancer

Priority Symptoms Identified in Recurrent Ovarian Cancer

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There are 18 core priority symptoms that should be routinely assessed in patients with recurrent ovarian cancer to provide higher quality of care.

Web-based Symptom Management Improves Symptom Controllability in Ovarian Cancer

Web-based Symptom Management Improves Symptom Controllability in Ovarian Cancer

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Nurse-guided and self-directed web-based symptom management interventions (WRITE Symptoms) improved symptom controllability among women with recurrent ovarian cancer.

Comorbidities May Predict Non-Home Discharge After Hysterectomy

Comorbidities May Predict Non-Home Discharge After Hysterectomy

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Presence of 1 risk factor or 2 or more risk factors is associated with non-home discharge after hysterectomy for gynecologic malignancy.

Some Quality Metrics Inconsistent With Long-Term Clinical Outcomes Goals

Some Quality Metrics Inconsistent With Long-Term Clinical Outcomes Goals

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Study finds that instituting a health system-wide quality metric, such as postoperative hospital readmission rate, may be inconsistent with long-term clinical outcomes goals.

Perioperative Pain Control Reduces Need for Postoperative Narcotics After Hysterectomy for Uterine Cancer

Perioperative Pain Control Reduces Need for Postoperative Narcotics After Hysterectomy for Uterine Cancer

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Preoperative intravenous acetaminophen plus local infiltration of LB during hysterectomy and surgical staging of uterine cancer may reduce the need for postoperative narcotics.

Perioperative Celecoxib Reduces Outpatient Narcotic Use After Hysterectomy

Perioperative Celecoxib Reduces Outpatient Narcotic Use After Hysterectomy

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Perioperative celecoxib use during hysterectomy may reduce the need for oral narcotics after hospital discharge.

Chemotherapy or VBT Improve Survival in Uterine Papillary Serous Carcinoma

Chemotherapy or VBT Improve Survival in Uterine Papillary Serous Carcinoma

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Use of chemotherapy or vaginal brachytherapy (VBT) may improve survival among patients with early-stage uterine papillary serous carcinoma.

High Rates of Persistent Opioid Use 6 Months After RT for Cervical Cancer

High Rates of Persistent Opioid Use 6 Months After RT for Cervical Cancer

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Nearly 3 in 10 cervical cancer survivors were still using opioids at 6 months after completing radiotherapy.

Nonadherence to Guidelines, Low-Volume Centers Linked to Lower Cervical Cancer Survival

Nonadherence to Guidelines, Low-Volume Centers Linked to Lower Cervical Cancer Survival

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Nonadherence to NCCN guideline treatment recommendations was strongly associated with decreased survival from early-stage cervical cancer.

HPV Vaccination Discussions Need to Focus on Education, Awareness

HPV Vaccination Discussions Need to Focus on Education, Awareness

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The top reasons for not initiating HPV vaccination are necessity, safety, and knowledge, rather than a lack of discussions on sexuality.

Ovarian Cancer: Distinct Clusters of Chemotherapy Nonresponders Identified

Ovarian Cancer: Distinct Clusters of Chemotherapy Nonresponders Identified

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A study that integrated genomic and clinical data identified 3 distinct clusters of patients with serous epithelial ovarian cancer who do not respond to chemotherapy.

Recovery Program After Laparotomy More Cost-Effective Than Usual Care

Recovery Program After Laparotomy More Cost-Effective Than Usual Care

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An enhanced recovery program is more cost-effective than usual care in patients undergoing primary cytoreductive surgery for ovarian cancer.

Rucaparib Active in Relapsed, Platinum-sensitive Ovarian Cancer

Rucaparib Active in Relapsed, Platinum-sensitive Ovarian Cancer

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Rucaparib was active with an acceptable safety profile in patients with relapsed, platinum-sensitive high-grade ovarian carcinoma with germline or somatic BRCA mutations.

Multidisciplinary Team Approach Reduces Cervical Cancer Treatment Delays in Low-Resource Areas

Multidisciplinary Team Approach Reduces Cervical Cancer Treatment Delays in Low-Resource Areas

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Multidisciplinary team approach reduces cervical cancer treatment delays in Botswana by 50%.

PI3K/mTOR Inhibitor Demonstrates Efficacy in Some Uterine Sarcomas

PI3K/mTOR Inhibitor Demonstrates Efficacy in Some Uterine Sarcomas

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A new generation dual PI3K/mTOR inhibitor shows promise in treating leiomyosarcomas with the protein P-S6S240.

HMT Improves PFS in Serous Carcinoma of the Ovary, Peritoneum

HMT Improves PFS in Serous Carcinoma of the Ovary, Peritoneum

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Individuals with serious carcinoma of the ovary or peritoneum experienced improved progression-free survival after hormone maintenance therapy.

Women May Significantly Benefit from Entering OB/GYN Clinical Trials

Women May Significantly Benefit from Entering OB/GYN Clinical Trials

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The researchers hope the results will lead to an increase in clinicians offering trials to their patients and an increase in women volunteering to participate in trials.

Intentional Weight Loss Associated With Endometrial Cancer Risk

Intentional Weight Loss Associated With Endometrial Cancer Risk

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The impact of weight loss on risk for endometrial cancer in postmenopausal women was assessed in women enrolled in the Women's Health Initiative observational study.

Early Endometrial Cancer Surgery May Reduce Survival

Early Endometrial Cancer Surgery May Reduce Survival

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The timing of surgery taking place following an endometrial cancer diagnosis may adversely impact survival.

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

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The benefits of primary cytoreductive surgery relative to neoadjuvant chemotherapy remain uncertain; therefore, researchers performed a retrospective data analysis to compare overall survival of surgery with that of neoadjuvant chemotherapy in advanced-stage epithelial ovarian cancer.

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

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Researchers report on the feasibility of a nurse-led sexual rehabilitation intervention to target sexual recovery and vaginal dilation in women who underwent pelvic radiation therapy and brachytherapy for gynecologic cancers.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

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Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

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Rapid, robust, and affordable genetic testing for patients with ovarian cancer that allows a much larger portion of patients to benefit from personalized cancer management and their relatives to benefit from preventive strategies can be achieved.

Socioeconomic Status Inversely Related to Risk for Ovarian Cancer in African American Women

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Risk of ovarian cancer is higher in African American women with lower socioeconomic status, the opposite of trends seen in breast cancer.

Routine Pap Smears Improve Cervical Cancer Risk in Women Older Than 65 Years

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Despite confirmation of a link between routine Pap smear screening and a lower risk of developing cervical cancer in women older than 65 years, most US health guidelines discourage older women from undergoing routine Pap smears unless they have pre-existing risk factors.

Prophylactic Gynecologic Resections Increase Risk for Aggressive Uterine Cancer in BRCA Gene Mutation Carriers

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Women who carry the BRCA1 mutation are at increased risk for serous/serous-like endometrial carcinoma after risk-reducing salpingo-oophorectomy. Yet uncertainty exists over the need to perform a full hysterectomy in these women.

HPV Vaccination Program Reduces Cervical Cell Anomalies in Young Women

HPV Vaccination Program Reduces Cervical Cell Anomalies in Young Women

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Fewer cervical cell anomalies were present on cervical cancer screens of young women in Canada who received the HPV vaccine through a school-based program.

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