Gynecologic Cancer

Ado-trastuzumab Emtansine Effective in HER2 Amplified Non-breast, Non-gastric Cancers

Ado-trastuzumab Emtansine Effective in HER2 Amplified Non-breast, Non-gastric Cancers

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Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

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In a case study, olaparib was found to induce folate deficiency in most patients with relapsed ovarian cancer. Researchers discuss the significance of this adverse effect and how it was managed.

Novel Agents Plus Paclitaxel, Carboplatin, Does Not Improve Survival in Endometrial Cancer

Novel Agents Plus Paclitaxel, Carboplatin, Does Not Improve Survival in Endometrial Cancer

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A phase 2 study determined if adding bevacizumab or temsirolimus to PC, or an ixabepilone/carboplatin/bevacizumab combination will increase progression-free survival for women with advanced/recurrent endometrial cancer, compared with PC alone.

Multimodal Follow-up Improved Postradiotherapy Sexual Health in Lower GI, Gynecologic Cancers

Multimodal Follow-up Improved Postradiotherapy Sexual Health in Lower GI, Gynecologic Cancers

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Researchers sought to determine the effectiveness of a multimodal continuity of care program for women receiving radiation therapy for gynecologic or lower GI cancers. Their findings were presented at the 2018 ONS Annual Congress.

Reflexology, Aromatherapy May Reduce Pain, Anxiety of Brachytherapy for Cervical Cancer

Reflexology, Aromatherapy May Reduce Pain, Anxiety of Brachytherapy for Cervical Cancer

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A study presented at the 2018 ONS Annual Congress explored whether aromatherapy and reflexology can ease anxiety and pain for patients undergoing brachytherapy for cervical cancer.

Risk for Long-Term Cardiovascular Disease Increased for Endometrial Cancer Survivors

Risk for Long-Term Cardiovascular Disease Increased for Endometrial Cancer Survivors

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Study investigates the risk for cardiovascular events among survivors of endometrial cancer, and the effect of treatment — chemotherapy vs chemotherapy plus radiotherapy — on survivors' risk for CVD.

Methotrexate Courses for Postmolar GTN Unchanged After Re-Cutterage

Methotrexate Courses for Postmolar GTN Unchanged After Re-Cutterage

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Researchers sought to examine the affect of uterine re-curettage on the number of methotrexate courses required for patients with postmolar gestational trophoblastic neoplasia.

Adding Trastuzumab to Uterine Serous Carcinoma Treatment Extended PFS

Adding Trastuzumab to Uterine Serous Carcinoma Treatment Extended PFS

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Researchers explored whether adding trastuzumab to carboplatin and paclitaxel would improve survival outcomes for patients with advanced/recurrent disease with overexpressed HER2/neu.

Opioid Use After Gynecologic Surgery Reduced With Prescription Protocol

Opioid Use After Gynecologic Surgery Reduced With Prescription Protocol

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Use of an opioid prescription protocol greatly reduced opioid use among patients who underwent gynecologic surgery, according to presentation at the 2018 Society of Gynecologic Oncology Annual Meeting on Women's Cancer.

5-Year Overall Survival in Endometrial Cancer Not Improved With Chemoradiotherapy

5-Year Overall Survival in Endometrial Cancer Not Improved With Chemoradiotherapy

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A report from a phase 3 study on the 5-year failure-free survival of women with endometrial cancer treated with radiation therapy alone vs chemoradiotherapy plus adjuvant chemotherapy.

Vulvar Carcinoma: Dilemma, Debates, and Decisions

Vulvar Carcinoma: Dilemma, Debates, and Decisions

[Cancer Management and Research] A review of vulvar carcinoma and treatment options for patients with rare gynecologic cancer.

Prevention, Management of Hand-Foot Syndrome With Cooling Therapy

Prevention, Management of Hand-Foot Syndrome With Cooling Therapy

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Researchers explored the effectiveness of wearing frozen gloves and socks before and after treatment with PLD to prevent or manage hand-foot syndrome in patients with ovarian cancer.

Comparison of Survival Outcomes Between Radical Hysterectomy and Definitive Radiochemotherapy in Stage IB1 and IIA1 Cervical Cancer

Comparison of Survival Outcomes Between Radical Hysterectomy and Definitive Radiochemotherapy in Stage IB1 and IIA1 Cervical Cancer

[Cancer Management and Research] A comparison study evaluated whether radical hysterectomy or radiochemotherapy provides superior survival outcomes for patients with stage IB1 or IIA1 cervical cancer.

Blueberry Extract May Boost Efficacy of Radiotherapy for Cervical Cancer

Blueberry Extract May Boost Efficacy of Radiotherapy for Cervical Cancer

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In an effort to find alternatives to cisplatin as a radiation sensitizer, due to its dose-dependent toxicity and resistance, researchers are exploring food-based options such as blueberry extract.

Pazopanib Plus Paclitaxel Does Not Improve Outcomes in Recurrent Ovarian Cancer

Pazopanib Plus Paclitaxel Does Not Improve Outcomes in Recurrent Ovarian Cancer

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Results of a double-blind phase 2 study determined if adding oral pazopanib to intravenous paclitaxel improved outcomes for women with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.

Vaginal Cuff Brachytherapy in Endometrial Cancer - A Technically Easy Treatment?

Vaginal Cuff Brachytherapy in Endometrial Cancer - A Technically Easy Treatment?

[Cancer Management and Research] This research examines vaginal cuff brachytherapy (VCB) in the postoperative treatment of high- to intermediate-risk endometrial cancer.

Niraparib Maintains Quality of Life in Recurrent Ovarian Cancer

Niraparib Maintains Quality of Life in Recurrent Ovarian Cancer

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Administering niraparib to patients with recurrent ovarian cancer after CR or PR to platinum-based chemotherapy may allow patients to continuously maintain QOL during treatment, reported researchers in presentation at ESMO 2017 Congress.

Sexual Dysfunction in Women With Cancer: A Review of Available Interventions

Sexual Dysfunction in Women With Cancer: A Review of Available Interventions

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Investigators conducted a review of available biologic and psychosocial interventions that address sexual dysfunction in women arising from cancer diagnosis and treatment.

Incidence of Invasive Cervical Cancer May Not Be Affected by HIV Status

Incidence of Invasive Cervical Cancer May Not Be Affected by HIV Status

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HIV infection may not have a contributory effect on the incidence of invasive cervical cancer (ICC) in women as they age.

Rates of Pregnancy Significantly Lower in Cancer Survivors Compared With General Population

Rates of Pregnancy Significantly Lower in Cancer Survivors Compared With General Population

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Girls and women aged 39 years and younger may be up to 38% less likely to achieve pregnancy after surviving cancer vs patients who have never had cancer.

Quality of Life in Ovarian Cancer Not Diminished by Olaparib

Quality of Life in Ovarian Cancer Not Diminished by Olaparib

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Change in FACT-O TOI score from baseline to 12 months did not differ significantly between maintenance olaparib and placebo.

Vaccine for Cervical Cancer Could Extend Survival in Relapsed Disease

Vaccine for Cervical Cancer Could Extend Survival in Relapsed Disease

Axalimogene filolisbac, an intravenous vaccine currently in clinical trials, could prevent often-fatal cervical cancer relapse.

Abdominal vs Laparoscopic Hysterectomy: Outcomes Similar for Endometrial Cancer

Abdominal vs Laparoscopic Hysterectomy: Outcomes Similar for Endometrial Cancer

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Disease-free survival and overall survival were similar in a study comparing total abdominal vs total laparoscopy hysterectomy approaches in women with stage I endometrial cancer.

Concurrent, Maintenance Therapy With Cediranib Maintains QOL in Ovarian Cancer

Concurrent, Maintenance Therapy With Cediranib Maintains QOL in Ovarian Cancer

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Quality of life was maintained in patients with ovarian cancer who received chemotherapy with concurrent cediranib then cediranib alone as maintenance therapy.

12 More Genetic Variants Found to Increase Risk for Ovarian Cancer

12 More Genetic Variants Found to Increase Risk for Ovarian Cancer

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A team of international researchers identified 12 new genetic variants that increase a woman's risk of developing ovarian cancer.

ASCO Issues Global Guidance for HPV Vaccination for Cervical Cancer Prevention

ASCO Issues Global Guidance for HPV Vaccination for Cervical Cancer Prevention

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ASCO offers global recommendations for HPV vaccination tailored to structural resource levels of regions.

Parental Self-persuasion in Low-Income Groups Improves HPV Vaccination Rates

Parental Self-persuasion in Low-Income Groups Improves HPV Vaccination Rates

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Self-persuasion is more effective than external persuasion for motivating low-income parents to vaccinate their children against HPV.

Quarterly Testing for Biomarker Improves Detection of Early-Stage Ovarian Cancer in High-Risk Women

Quarterly Testing for Biomarker Improves Detection of Early-Stage Ovarian Cancer in High-Risk Women

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A protocol of testing of CA125 levels quarterly with subsequent transvaginal ultrasound examination increased detection of early-stage ovarian cancer in women at high-risk for the disease.

Screening Increases Early Palliative Care, Reduces Aggressive EOL Measures

Screening Increases Early Palliative Care, Reduces Aggressive EOL Measures

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Universal screening of women with gynecologic malignancies for early palliative care decreased the use of aggressive measures at the end of life.

Endometrial Cancer Survivors in High-Poverty Areas Have Impaired Access to Self-Care Resources

Endometrial Cancer Survivors in High-Poverty Areas Have Impaired Access to Self-Care Resources

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Living in a high-poverty region is associated with lower access to obesity-related self-care resources.

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