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GRANISOL
Nausea
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Drug Name:

GRANISOL Rx

Generic Name and Formulations:
Granisetron (as HCl) 1mg/5mL; soln; orange-flavor.

Company:
PediatRx, Inc.

Therapeutic Use:

Indications for GRANISOL:

Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin) or with radiation (including total body irradiation and fractionated abdominal radiation).

Adult:

Chemotherapy: give only on the days chemo is given. 2mg once daily up to 1 hour before chemo; or, 1mg up to 1 hour before chemo, then 1mg 12 hours after 1st dose. Radiation: 2mg once daily within 1 hour of radiation.

Children:

Not recommended.

Warnings/Precautions:

Pre-existing arrhythmias or cardiac conduction disorders. Increased risk of QT prolongation: cardiac disease, on cardio-toxic chemotherapy, electrolyte abnormalities and/or concomitant drugs that prolong the QT interval. Abdominal surgery. May mask progressive ileus and/or gastric distention. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Caution with drugs that affect CYP450 or drugs known to prolong the QT interval and/or are arrhythmogenic.

Pharmacological Class:

Selective 5-HT3 receptor antagonist.

Adverse Reactions:

Headache, asthenia, diarrhea, constipation, abdominal pain; QT prolongation.

How Supplied:

Soln—30mL

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