Glioma

A Systematic Review and Meta-analysis of the Risk of Diarrhea Associated With Vandetanib Treatment in Carcinoma Patients

A Systematic Review and Meta-analysis of the Risk of Diarrhea Associated With Vandetanib Treatment in Carcinoma Patients

[OncoTargets and Therapy] This research examines overall risks of all-grade and high-grade diarrhea during vandetanib treatment, to gain a better understanding of its prediction and management.

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

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The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

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The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

Radiotherapy/Histone Deacetylase Inhibitor Combination Safe, Effective in High-grade Gliomas

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Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.

Hypnosedation: An Alternative Sedation Method for Glioma Resection

Hypnosedation: An Alternative Sedation Method for Glioma Resection

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This technique, which does not use pharmaceutical sedatives, can ease the perioperative discomfort and anxiety experienced by some patients undergoing fully awake craniotomy to remove glioma.

Pan-glioma Analysis Reveals Unique Subtypes of This Brain Cancer

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Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.

Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors

Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors

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Brain tumor cells can self-organize, according to new research. Glioma cells build tumors by self-organizing into streams 10 to 20 cells wide that obey a mathematically predicted pattern for autonomous agents flowing together.

Action of Signaling Pathway Surprises Researchers Investigating Brain Tumor Development

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A signaling pathway present in most organisms suppresses the formation of specific types of brain tumor.

Five New Genetic Variants Linked With Glioma Identified

Five New Genetic Variants Linked With Glioma Identified

Five new genetic variants associated with glioma have been identified in the biggest ever study of DNA in patients within this population.

Non-Oral Benzodiazepine Combination Feasible for Seizures in Patients With Gliomas

Non-Oral Benzodiazepine Combination Feasible for Seizures in Patients With Gliomas

It is feasible to treat seizures with a combination of non-oral benzodiazepines in the end-of-life phase of patients with gliomas.

Complete resection of high-grade gliomas improves survival in children, especially girls

Complete resection of high-grade gliomas improves survival in children, especially girls

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For children with high-grade gliomas, the chances of survival are improved when surgery is successful in eliminating all visible cancer.

Classification system offers precise determination of effectiveness of surgical resection of gliomas

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A new procedure for analyzing radiologic imaging scans increases the chance to accurately predict the course of malignant gliomas.

Low-grade brain tumor diagnosis redefined

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A tumor's DNA composition plays a key role in whether a glioma may transform into a more serious glioblastoma.

Combination therapy found best for low-grade brain tumors

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New evidence indicates that combining chemotherapy with radiation therapy may be the best option for people with a low-grade form of brain cancer.

Oral contraceptives may increase risk for developing gliomas

Oral contraceptives may increase risk for developing gliomas

Certain forms of birth control may increase the risk for developing a glioma, a rare brain cancer.

Chemotherapy after radiation slows progression of low-grade gliomas

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A chemotherapy regimen of procarbazine, lomustine (CCNU), and vincristine (PCV) administered after radiation therapy improved both progression-free survival and overall survival in adults with low-grade gliomas.

Wireless phone may increase risk of gliomas

Wireless phone may increase risk of gliomas

Risk of brain cancer is three times higher after 25 years or more of mobile phone use.

Web-based app predicts glioma mutations

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A new web-based program will provide a simple, free way for health care providers to determine which brain tumor cases require testing for a genetic mutation.

Newly identified brain cancer mutation may can aid drug development

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Researchers have identified a genetic mutation in brain cancer tumor cells that plays a role in both the growth and the death of the cell.

Gene sequencing discovers mutations tied to deadly brain tumors in young children

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New mutations in pediatric brain tumors known as high-grade gliomas have been identified, and most often occur in the youngest patients.

Radiation reduces long-term survival of low-grade pediatric gliomas

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The first large-scale cohort study of the long-term survival of children treated for low-grade gliomas found that almost 90% are alive 20 years later.

Adding chemotherapy after radiation improves survival for adults with low-grade gliomas

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Receiving a chemotherapy regimen following the completion of radiation therapy resulted in longer survival in adults with low-grade gliomas compared with those who received radiation therapy alone.

Targeting the mTOR pathway could treat pediatric gliomas

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A known genetic pathway is active in many difficult-to-treat pediatric brain tumors known as low-grade gliomas. This finding offers a potential new target for the treatment of these cancers.

Amino acid PET imaging improves care for children with glioma

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The amino acid imaging agent O-(2-[18F]-fluroethyl)-L-tyrosine (F-18 FET) has diagnostic benefit for imaging pediatric gliomas when conventional MRI is ineffective.

Trial favors radiotherapy over chemo as first choice for high-risk low-grade glioma

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First-line temozolomide did not offer improvements over radiotherapy for high-risk, low-grade glioma, according to a large, international, randomized trial. The two treatment strategies did not have a statistically significant difference for progression-free survival, although radiotherapy was numerically favored.

Trial identifies which patients with anaplastic oligodendroglioma benefit from adjuvant PCV

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Patients' CpG island methylator phenotype (CIMP) status and methylation of the O-6-methylguanine-DNA methyltransferase (MGMT) promoter are the most informative in identifying patients with grade III glioma who might benefit from adding procarbazine, CCNU, and vincristine (PCV) to radiation therapy

Bone marrow produces glioma treatment

Genetic material secreted by bone marrow cells was used to reduce glioma tumor volume in a recent study.

Stem cells from fat may aid glioblastoma treatment

Adipose tissue may provide a more efficient, less costly, and less invasive source of mesenchymal stem cells (MSCs) than bone marrow.

ELTD1 protein may be new biomarker for glioma

ELTD1, a protein linked with angiogenesis, is the strongest candidate for a significant association with glioma out of nearly 200 possible markers.

PET imaging helps guide glioma treatment

Imaging with 18F-FLT positron emission tomography provides tumor-specific details accurately and noninvasively in persons with gliomas.

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