Adding the anti-malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize glioblastoma patients to targeted treatments that had previously stopped working.
Chimeric antigen receptor (CAR) T cells may have improved therapeutic potential when they have 2 targets, according to preclinical findings using a mouse model.
Adding Temozolomide to Radiotherapy Improves Survival in Elderly Patients With Newly Diagnosed GlioblastomaJune 06, 2016
The addition of temozolomide to standard short-course radiation therapy significantly improved both overall and progression-free survival in elderly patients with newly diagnosed glioblastoma, results from the first study to test this combination in this age group concluded in a plenary presentation at the ASCO 2016 Annual Meeting.
The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers, attendees were told in a poster discussion session at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting.
Abemaciclib, an investigational cancer therapeutic, showed durable clinical activity as a continuous single-agent therapy, according to results of a phase 1 trial with 5 tumor-specific cohorts.
Discovery might eventually lead to better treatment for glioblastoma multiforme
Glioblastoma tumors were successfully infiltrated by investigational CAR therapy with an acceptable safety profile.
The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.
Bevacizumab plus irinotecan significantly improved the 6-month progression-free survival (PFS) rate and median progression-free survival.
Progression-free and overall survival were prolonged with electromagnetic field and chemotherapy maintenance therapy in patients with a brain tumor.
Adding tumor-treating fields to maintenance temozolomide chemotherapy significantly prolonged progression-free survival.
Combination Regimen for Recurrent Glioblastoma Improves Progression-free Survival, But Not Overall SurvivalDecember 08, 2015
Bevacizumab treatment combined with lomustine in patients with progressive glioblastoma, despite prolonged progression-free survival, does not confer a survival advantage.
[Clinical Medicine Insights: Oncology] This research examines hypoxia as a new therapeutic target for primary and secondary glioblastomas.
Scientists have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.
Liquid biopsy of cerebrospinal fluid has potential for prognosis, treatment, identification, and tracking of brain tumor genomic alterations both in real time and over time.
An experimental gene therapy essentially doubled the overall survival of patients with recurrent glioblastoma compared with the current standard of care.
The first study to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients has revealed specific structural brain changes.
Hampering communication between cancer cells slowed the rapid spread of a common and deadly brain tumor significantly in a mouse model.
Using human tumor samples and mouse models, researchers have found that cancer stem cell properties are determined by epigenetic changes.
Tumors can leverage glucose and acetate to resist targeted therapies directed at specific cellular molecules.
Clinicians testing dasatinib, approved for several blood cancers, were hoping to find that it would slow the growth of glioblastomas.
The adverse event profile of nivolumab with or without ipilimumab in patients with glioblastoma was encouraging.
A combination approach utilizing three differing anticancer drug classes could hold the key to besting glioblastoma.
An innovative pretreatment can enhance the effectiveness of immunotherapy for glioblastoma, dramatically improving patient survival.
Research into the transfer of proteins within the cells of patients with autism has helped broaden our understanding of brain cancer.
A new study has identified three genes that combined enable a lethal form of brain cancer to recur and progress after radiation therapy.
Researchers have found that bevacizumab-induced hypertension may be a predictive marker of improved outcomes in patients with recurrent glioblastoma who are treated with bevacizumab.
New evidence indicates that immune checkpoint inhibitors may work in glioblastoma and brain metastases.
A new drug breakthrough could extend the life of people living with glioblastoma, the most aggressive type of brain cancer.
Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumor's epigenetic signature.
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- Elderly with NSCLC Can Tolerate Aggressive Radiation Therapy Treatments
- Patients With Urologic Cancer Need Psycho-oncologic Support to Manage High Stress
- E-cigarettes and Replacement Nicotine Therapy Safer Than Tobacco Use
- Lung Cancer Screening Rates Low Among Present and Former Smokers
- Survivors Reporting Chronic Neuropathic Pain Struggle to Retain Jobs
- Timing of Chemotherapy Infusion Affects Inflammatory Response to Chemotherapy
- Postoperative Gemcitabine Plus Capecitabine: A New Standard of Care for Pancreatic Cancer
- Blood-Forming Stem Cell Transplants (Fact Sheet)
- Patients Undergoing Multiple Systemic Therapies for Metastatic Prostate Cancer Expect a Cure
- FDA Grants Priority Review to Ceritinib for First-line Treatment of ALK+ NSCLC
- Overall Health Worse in African American Men Undergoing Active Surveillance For Prostate Cancer
- Clinical Benefit of Simtuzumab Inconsistent for Myelofibrosis
- Follow-up Rates in Active Surveillance for Prostate Cancer Higher in University-Based vs Safety-Net Hospitals
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