Genomics

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

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The geometric shape of the outside edge of a cancerous tumor plays a significant role in activating tumor-seeding cells that lead to metastasis.

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

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Disparities in the gut microbiome between healthy people and women with estrogen-driven breast cancer may indicate possible biomarkers based on the microbiome that could help to mitigate the risk of certain cancers.

Precision Medicine Resource Center Improves Patient Education

Precision Medicine Resource Center Improves Patient Education

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A nurse-managed precision cancer treatment education resource center may improve information dissemination about genomic health and targeted therapy.

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

[Biomarkers in Cancer] This research examines the emerging role of genomic rearrangements in breast cancer, with a particular focus on fusion genes, and explores the therapeutic value of such rearrangements and their significance as predictive and prognostic biomarkers.

Significant Gap in Sequencing Limits the Potential of Precision Medicine

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Despite improvements in genomic sequencing technologies, a significant number of medically important genes are within genomic regions in which sequencing lacks the technical accuracy to generate reliable reads.

Full Disclosure of Data Sharing in Human Research Encourages Patient Participation

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Participation in human research may improve with full disclosure and increased transparency of the risks of participating in publicly shared, big-data research projects.

Pan-glioma Analysis Reveals Unique Subtypes of This Brain Cancer

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Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.

Targetable Genotype in Non-small Cell Lung Cancer Is More Likely in Younger Patients

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Patients younger than 50 years with NSCLC were more likely to have a targetable genomic alteration for which therapies exist.

Mix of Cell Types in Cancer Tumor Samples May Bias Genomic Analyses

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Genetic analyses and other tests performed by both researchers and physicians can be significantly skewed when normal cells, especially immune cells, are intermixed with cancerous cells in a tissue sample.

First Comprehensive Profile of Non-Protein-Coding RNAs in Human Cancers Is Identified

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An international team mined RNA sequences to identify non-protein-coding segments whose expression is linked to 13 different types of cancer.

Genome sequencing database provides easy access to information on clinically important cancer gene mutations

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Researchers designed an online database, the Cancer Driver Log (CanDL) to help oncologists and other health care professionals identify key mutations that drive tumor growth in tissues.

Researchers identify tumor microenvironment of metastasis (TMEM) that allows breast cancer to metastasize

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Using high-resolution imaging, scientists have gained a greater understanding of how a doorway in the blood vessel wall allows cancer cells to metastasize.

Unraveling of molecular changes in acute lymphoblastic leukemia (ALL) opens new treatment options

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An international team has decoded the molecular characteristics of acute lymphoblastic leukemia (ALL), a cancer with some incurable subtypes.

Navigators have a key role in using genetics and genomics for cancer risk identification

Navigators have a key role in using genetics and genomics for cancer risk identification

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DENVER, CO—The nurse navigator's role in cancer risk identification is three-fold. Despite the changes brought on by genetic/genomics, aspects of the nursing role are consistent with the essential competencies required of all professional nurses, according to a presentation at the 2015 Oncology Nurse Advisor Navigation Summit.

Researchers home in on what is wearing out T cells

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A new study indicates that the PD-1 protein pathway may niot be the only primary player in T cell exhaustion.

Researchers map genomic landscape of childhood adrenocortical tumors for first time

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Genomic mapping of malignant pediatric adrenocortical tumors has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.

Cell signaling pathway goes awry in common pediatric brain tumor

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A new study links a well-known cell communication pathway called Notch to pilocytic astrocytoma (PA), one of the more common brain tumors found in children.

Circulating RNA may provide prognostic tool for multiple myeloma

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The molecular mail sent by multiple myeloma cells provides clues to how well patients with the disease are likely to respond to treatment, according to a study presented at ASH. The findings may ultimately guide doctors in deciding which therapies are best for individual patients with myeloma.

Personalized medicine and the role of the navigator: Prostate cancer

Personalized medicine and the role of the navigator: Prostate cancer

Molecular tests are poised to become a part of the treatment guidelines for prostate cancer. These tests provide information that extends beyond just identifying the type of cancer a patient has; they can also help narrow down treatment options to those that offer the best outcomes for patients.

TCGA study of thyroid genome finds markers of aggressive tumors

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A new comprehensive analysis of thyroid cancer from The Cancer Genome Atlas (TCGA) Research Network has identified markers of aggressive tumors, which could allow for improved targeted therapy.

Cytokine therapy enhances natural killer cell functions against tumor cells

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Cytokine therapy enhances the activity of natural killer (NK) cells against tumors that lack the cell surface protein known as MHC class I, according to new research.

Hormone loss could be involved in colon cancer

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Evidence now suggests that human colon cells may become cancerous when they lose the ability to produce a specific hormone. For patients with colon cancer, replacing the hormone guanylin might prevent cancer development.

Blocking STAT3 may increase antitumor immune response

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Blocking STAT3 in cells of the immune system actually leads to increased antitumor immunity, according to new research.

JAK inhibitors promising in colorectal cancer

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JAK inhibitors have been found to halt tumor growth in colorectal cancer with a certain genetic mutation, according to a new study.

Better classifications improve treatment planning for breast cancer

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Scientists have developed a tool to distinguish each breast cancer subtype, research that could improve treatments and targeting of treatments for the disease.

Genetic sequence of rare kidney cancer reveals unique alterations involving telomerase

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An international scientific collaboration has revealed clues about genetic alterations that may contribute to a rare form of kidney cancer, providing new insights not only into this rare cancer but other types as well.

Cancer leaves a common fingerprint on DNA

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All types of cancers appear to share a telltale signature of widespread changes to the epigenome.

Tumor suppressor mutations alone do not explain deadly cancer

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Although mutations in a gene dubbed the "guardian of the genome" are recognized as being associated with more aggressive cancers, evidence suggests that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities.

Gene likely to promote childhood cancers pinpointed

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Researchers have identified a gene that contributes to the development of several childhood cancers, research that could lead to new strategies for targeting certain childhood cancers at a molecular level.

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