ESR1 mutations are more frequent in patients with estrogen receptor (ER)-positive metastatic breast cancer that are treated with aromatase inhibitors, according to recent study data.
The National Cancer Moonshot needs to target proteins that are driving cancer rather than focusing only on genomics, a new paper suggests.
The geometric shape of the outside edge of a cancerous tumor plays a significant role in activating tumor-seeding cells that lead to metastasis.
Disparities in the gut microbiome between healthy people and women with estrogen-driven breast cancer may indicate possible biomarkers based on the microbiome that could help to mitigate the risk of certain cancers.
A nurse-managed precision cancer treatment education resource center may improve information dissemination about genomic health and targeted therapy.
[Biomarkers in Cancer] This research examines the emerging role of genomic rearrangements in breast cancer, with a particular focus on fusion genes, and explores the therapeutic value of such rearrangements and their significance as predictive and prognostic biomarkers.
Despite improvements in genomic sequencing technologies, a significant number of medically important genes are within genomic regions in which sequencing lacks the technical accuracy to generate reliable reads.
Participation in human research may improve with full disclosure and increased transparency of the risks of participating in publicly shared, big-data research projects.
Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.
Patients younger than 50 years with NSCLC were more likely to have a targetable genomic alteration for which therapies exist.
Genetic analyses and other tests performed by both researchers and physicians can be significantly skewed when normal cells, especially immune cells, are intermixed with cancerous cells in a tissue sample.
An international team mined RNA sequences to identify non-protein-coding segments whose expression is linked to 13 different types of cancer.
Genome sequencing database provides easy access to information on clinically important cancer gene mutationsSeptember 25, 2015
Researchers designed an online database, the Cancer Driver Log (CanDL) to help oncologists and other health care professionals identify key mutations that drive tumor growth in tissues.
Researchers identify tumor microenvironment of metastasis (TMEM) that allows breast cancer to metastasizeAugust 28, 2015
Using high-resolution imaging, scientists have gained a greater understanding of how a doorway in the blood vessel wall allows cancer cells to metastasize.
An international team has decoded the molecular characteristics of acute lymphoblastic leukemia (ALL), a cancer with some incurable subtypes.
DENVER, CO—The nurse navigator's role in cancer risk identification is three-fold. Despite the changes brought on by genetic/genomics, aspects of the nursing role are consistent with the essential competencies required of all professional nurses, according to a presentation at the 2015 Oncology Nurse Advisor Navigation Summit.
A new study indicates that the PD-1 protein pathway may niot be the only primary player in T cell exhaustion.
Genomic mapping of malignant pediatric adrenocortical tumors has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.
A new study links a well-known cell communication pathway called Notch to pilocytic astrocytoma (PA), one of the more common brain tumors found in children.
The molecular mail sent by multiple myeloma cells provides clues to how well patients with the disease are likely to respond to treatment, according to a study presented at ASH. The findings may ultimately guide doctors in deciding which therapies are best for individual patients with myeloma.
Molecular tests are poised to become a part of the treatment guidelines for prostate cancer. These tests provide information that extends beyond just identifying the type of cancer a patient has; they can also help narrow down treatment options to those that offer the best outcomes for patients.
A new comprehensive analysis of thyroid cancer from The Cancer Genome Atlas (TCGA) Research Network has identified markers of aggressive tumors, which could allow for improved targeted therapy.
Cytokine therapy enhances the activity of natural killer (NK) cells against tumors that lack the cell surface protein known as MHC class I, according to new research.
Evidence now suggests that human colon cells may become cancerous when they lose the ability to produce a specific hormone. For patients with colon cancer, replacing the hormone guanylin might prevent cancer development.
Blocking STAT3 in cells of the immune system actually leads to increased antitumor immunity, according to new research.
JAK inhibitors have been found to halt tumor growth in colorectal cancer with a certain genetic mutation, according to a new study.
Scientists have developed a tool to distinguish each breast cancer subtype, research that could improve treatments and targeting of treatments for the disease.
An international scientific collaboration has revealed clues about genetic alterations that may contribute to a rare form of kidney cancer, providing new insights not only into this rare cancer but other types as well.
All types of cancers appear to share a telltale signature of widespread changes to the epigenome.
- Breast Cancer Tumors Often a Composite of Tumor Types, Enhancing Treatment Resistance
- Massage Therapy Promising for Pain, Anxiety in Patients With Cancer
- Physical Activity May Reduce Mortality by 44% in Patients With Breast Cancer
- Hormone Receptor Test Results in DCIS Core Needle Biopsy Not Used, Not Needed
- Early Tumor Size Change May Predict OS in Metastatic Breast Cancer
- Exercise is as Effective in Treating Metastatic Prostate Cancer as Medication
- Walnut Consumption Changes Gut Microbiome, Decreases Growth of Colon Cancer in Mice
- Triple-Drug Therapy Produces Response in Triple-Negative Breast Cancer, Mouse Study Shows
- Vaccine Enters Phase I Study for Safety and Effectiveness in Multiple Myeloma
- Study Supports Increased Role for Surgery in Multimodality Therapy for Early Stage SCLC
- Users Support Indoor Tanning Device Age Restrictions, Stronger Health Warnings, But Not Total Ban
- Bone Marrow vs Bloodstream: Stem Cell Source Influences Transplantation Outcomes
- Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer
- Adolescent Girls With Breast Cancer Family History Have Higher Self-esteem
- Gemcitabine Plus Cisplatin Prolongs PFS in Nasopharyngeal Cancer
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