Genomics

Metabolism of Next-Generation Prostate Cancer Drugs Share Similarities

Metabolism of Next-Generation Prostate Cancer Drugs Share Similarities

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How the body metabolizes next-generation anti-androgen agents affects their anti-tumor activity in the treatment of prostate cancer.

Personalized Medicine and the Role of the Oncology Navigator

Personalized Medicine and the Role of the Oncology Navigator

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As molecular testing becomes the standard of care for many cancers, nurse navigators have an important role to play ensuring molecular testing of suitable patients, providing patient education, and managing of patient expectations.

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

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Precision Medicine Improves Pancreatic Cancer Treatment

Analysis & Perspective on Practical and Ethical Use and Interpretation of Whole Genome Sequencing Data During Clinical Trials

Analysis & Perspective on Practical and Ethical Use and Interpretation of Whole Genome Sequencing Data During Clinical Trials

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Despite the value of genomic sequence information, nurses need to be aware of the limitations of this information and ethical concerns regarding sharing it with patients.

E4 Steroid Reduces Testosterone Levels, Treats Advanced Prostate Cancer

E4 Steroid Reduces Testosterone Levels, Treats Advanced Prostate Cancer

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Steroid produced by human fetal liver reduces testosterone levels, holding potential as treatment for advanced prostate cancer.

Protein Suppresses Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Protein Suppresses Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia

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Research on the transformation of MDS to AML identifies a protein whose deletion is a potential tumor suppressor that would block this disease progression.

Genetic Similarity to BRCA1/BRCA2 Mutations May Impact Treatment Options

Genetic Similarity to BRCA1/BRCA2 Mutations May Impact Treatment Options

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Genetic signatures similar to BRCA1/BRCA2 mutations could make PARP inhibition a treatment option for some breast cancers.

Genome Sequencing Explains Resistance to CTLA-4 and PD-1 Inhibitors in Metastatic Melanoma

Genome Sequencing Explains Resistance to CTLA-4 and PD-1 Inhibitors in Metastatic Melanoma

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Whole-exome sequencing of tumor biopsies explain low response rate to immunotherapy in metastatic melanoma.

CRISPR Illustrates Progression of Normal Blood Cells to Leukemia, Precursor Diseases

CRISPR Illustrates Progression of Normal Blood Cells to Leukemia, Precursor Diseases

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Genome editing technology illustrates progression of normal blood cells to leukemia.

Decipher Genomic Classifier Prognostic for Distant Prostate Metastasis

Decipher Genomic Classifier Prognostic for Distant Prostate Metastasis

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The Decipher genomic classifier obtained from biopsy samples was prognostic for distant metastases and prostate cancer-specific mortality.

Direct-to-Consumer Cancer Risk Tests Prompt Few Changes in Exercise, Diet, Cancer Screening

Direct-to-Consumer Cancer Risk Tests Prompt Few Changes in Exercise, Diet, Cancer Screening

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The majority of consumers do not change their health-related behaviors in the wake of personal genomic test results.

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

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Given the frequency of gene mutations in patients with early-onset CRC, genetic counseling and testing could be considered for this population.

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

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The recurrence score assay stratifies early stage, estrogen receptor-positive breast cancer by recurrence risk. This study assessed how clinicians use the recurrence score to recommend adjuvant systemic therapy or patients' experiences with testing decision-making.

New Research Identifies Potential Bladder Cancer Chemotherapy Side Effect

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A recent study undertaken sought to examine the effects of chemotherapy on bladder cancer cells and possible connections to later treatment resistance.

Epigenetic Profiling Improves Identification of Primary Tumor in CUP

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DNA methylation profiling identified the primary cancer in cases of cancer of unknown primary, informing tumor-type specific treatment that improved overall survival in these patients.

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

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Applying evolutionary theory improves the accuracy of predicting in which patients Barrett's esophagus will progress to esophageal adenocarcinoma.

Genomic Sequencing Data May Widen Racial and Ethnic Health Disparities

Genomic Sequencing Data May Widen Racial and Ethnic Health Disparities

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Precision medicine based on genetic makeup of tumors is leading to anticancer treatments that target specific patients; however, racial and ethnic minorities are underrepresented in genomic samples, resulting in less benefit from advances in cancer care for these patients.

MammaPrint Helps to Identify Which Patients Require Adjuvant Chemotherapy

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The 70-gene signature test, in combination with standard clinical-pathologic criteria, may help clinicians decide whether patients with early stage breast cancer who are at high clinical risk require adjuvant chemotherapy.

ESR1 Mutations Prevalent in ER+ Metastatic Breast Cancer

ESR1 Mutations Prevalent in ER+ Metastatic Breast Cancer

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ESR1 mutations are more frequent in patients with estrogen receptor (ER)-positive metastatic breast cancer that are treated with aromatase inhibitors, according to recent study data.

Including Proteomics Is Key to Achieving Goals of National Cancer Moonshot

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The National Cancer Moonshot needs to target proteins that are driving cancer rather than focusing only on genomics, a new paper suggests.

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

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The geometric shape of the outside edge of a cancerous tumor plays a significant role in activating tumor-seeding cells that lead to metastasis.

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

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Disparities in the gut microbiome between healthy people and women with estrogen-driven breast cancer may indicate possible biomarkers based on the microbiome that could help to mitigate the risk of certain cancers.

Precision Medicine Resource Center Improves Patient Education

Precision Medicine Resource Center Improves Patient Education

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A nurse-managed precision cancer treatment education resource center may improve information dissemination about genomic health and targeted therapy.

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

[Biomarkers in Cancer] This research examines the emerging role of genomic rearrangements in breast cancer, with a particular focus on fusion genes, and explores the therapeutic value of such rearrangements and their significance as predictive and prognostic biomarkers.

Significant Gap in Sequencing Limits the Potential of Precision Medicine

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Despite improvements in genomic sequencing technologies, a significant number of medically important genes are within genomic regions in which sequencing lacks the technical accuracy to generate reliable reads.

Full Disclosure of Data Sharing in Human Research Encourages Patient Participation

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Participation in human research may improve with full disclosure and increased transparency of the risks of participating in publicly shared, big-data research projects.

Pan-glioma Analysis Reveals Unique Subtypes of This Brain Cancer

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Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.

Targetable Genotype in Non-small Cell Lung Cancer Is More Likely in Younger Patients

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Patients younger than 50 years with NSCLC were more likely to have a targetable genomic alteration for which therapies exist.

Mix of Cell Types in Cancer Tumor Samples May Bias Genomic Analyses

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Genetic analyses and other tests performed by both researchers and physicians can be significantly skewed when normal cells, especially immune cells, are intermixed with cancerous cells in a tissue sample.

First Comprehensive Profile of Non-Protein-Coding RNAs in Human Cancers Is Identified

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An international team mined RNA sequences to identify non-protein-coding segments whose expression is linked to 13 different types of cancer.

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