Genomics

JAK inhibitors promising in colorectal cancer

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JAK inhibitors have been found to halt tumor growth in colorectal cancer with a certain genetic mutation, according to a new study.

Better classifications improve treatment planning for breast cancer

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Scientists have developed a tool to distinguish each breast cancer subtype, research that could improve treatments and targeting of treatments for the disease.

Genetic sequence of rare kidney cancer reveals unique alterations involving telomerase

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An international scientific collaboration has revealed clues about genetic alterations that may contribute to a rare form of kidney cancer, providing new insights not only into this rare cancer but other types as well.

Cancer leaves a common fingerprint on DNA

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All types of cancers appear to share a telltale signature of widespread changes to the epigenome.

Tumor suppressor mutations alone do not explain deadly cancer

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Although mutations in a gene dubbed the "guardian of the genome" are recognized as being associated with more aggressive cancers, evidence suggests that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities.

Gene likely to promote childhood cancers pinpointed

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Researchers have identified a gene that contributes to the development of several childhood cancers, research that could lead to new strategies for targeting certain childhood cancers at a molecular level.

Cancer-causing mechanism behind Myc oncogene uncovered

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A protein present at high levels in more than half of all human cancers drives cell growth by blocking the expression of just a handful of genes involved in DNA packaging and cell death.

Galectin-1 protein allows brain tumors to evade the immune system

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Brain tumors fly under the radar of the body's defense forces by coating their cells with extra amounts of a specific protein, according to new research.

Mutations in the PALB2 gene increases risk of breast cancer by age 70 years

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The PALB2 gene is potentially one of the most important genes associated with breast cancer after the BRCA1/2 genes.

Cancer categories recast in largest-ever genomic study

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New research suggests that cancer would be more accurately diagnosed in 1 of every 10 patients if their tumors were defined by cellular and molecular criteria rather than by the tissues in which they originated, and that this information, in turn, could lead to more appropriate treatments.

Genomic analysis clarifies subtypes of gastric cancer

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In a massive effort to catalog the molecular causes of stomach cancer, scientists have identified four subtypes of tumors based on shared mutations and other molecular abnormalities. They say the new classification promises to advance clinical research to develop improved therapies for the third-leading cancer killer worldwide.

Metabolic enzyme stops progression of most common kidney cancer

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In an analysis of small molecules called metabolites, a research team identified an enzyme key to applying the brakes on tumor growth.

Physicists reveal the random nature of metastasis

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The spreading of a cancerous tumor from one part of the body to another may occur through pure chance rather than through key genetic mutations, a new study has shown.

Scientists discover gene that prevents lung cancer metastasis

Scientists discover gene that prevents lung cancer metastasis

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Scientists have identified a gene responsible for stopping the movement of cancer from the lungs to other parts of the body, indicating a new way to fight one of the world's deadliest cancers.

Breakthrough identifies genes for resistance to MEK inhibitors in colorectal cancer

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A research team has discovered how two genes cause colorectal cancer cells to become resistant to treatments used against the disease.

Genes linked to breast cancer in East Asian women identified

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A new study has identified three genetic changes in East Asian women linked to an increased risk of breast cancer.

Single gene determines if rare lymphatic system cancer is aggressive

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For a rare form of cancer called thymoma, researchers have discovered a single gene defining the difference between a fast-growing tumor requiring aggressive treatment and a slow-growing tumor that does not require extensive therapy.

More than 40 melanoma-specific genes determine disease aggressiveness

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Researchers have discovered more than 40 genes that predict the level of aggressiveness of melanoma and that distinguish it from other cancers with a poor prognosis.

New approach identifies cancer mutations as targets of effective melanoma immunotherapy

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A new approach demonstrated that the recognition of unique cancer mutations appeared to be responsible for complete cancer regressions in two metastatic melanoma patients treated with a type of immunotherapy.

Protein inhibition opens door for pancreatic cancer treatment

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The protein galectin-1 has been identified as a possible therapeutic target for pancreatic cancer; new research has demonstrated that inhibiting this protein in mice with pancreatic cancer increased survival by 20%.

Genetic profile and potential drug susceptibility of breast cancer cells revealed by CTCs

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Circulating tumor cells captured with a microchip-based device can be cultured to establish cell lines for genetic analysis and drug testing.

New study reveals signaling pathway that can lead to cancer

New study reveals signaling pathway that can lead to cancer

Researchers from the University of Illinois at Chicago have discovered how cholesterol activates a cellular signaling pathway linked to cancer development. Previous studies have associated high cholesterol with certain cancers. But in this study, the researchers focused on the signaling pathways used to direct cell function.

New drug active against most aggressive type of lung cancer

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Scientists have shown that a new drug could prove useful in treating small cell lung cancer, the most aggressive form of lung cancer.

Gene mutation may lead to treatment for liver cancer

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Two genetic mutations in liver cells may drive tumor formation in intrahepatic cholangiocarcinoma (iCCA), the second most common form of liver cancer, according to new research.

Scientists bring personalized medicine for breast cancer one step closer

Scientists bring personalized medicine for breast cancer one step closer

The era of personalized medicine for breast cancer may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School.

Radiation-induced toxicity risk in prostate cancer predicted by variations in key gene

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Key genetic variants may affect how cancer patients respond to radiation treatments, according to a new study.

A Single Protein Could Unlock New Treatments For Brain Cancer

A Single Protein Could Unlock New Treatments For Brain Cancer

New research shows the protein neurons use to stay alive and healthy is used by brain cancer cells to maintain longevity to grow and metastasize. The findings could lead to breakthroughs in treatments for brain cancer.

Report offers a primer for clinical use of genome and exome sequencing

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New genome-based technology for the diagnosis of rare genetic illnesses is moving rapidly from research laboratories into general medical practice.

Genomics vs genetics: How are they different?

Genomics vs genetics: How are they different?

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This overview offers a simple guide for explaining to patients the difference between the terms, the tests, and what the results may mean.

Genomics of lung cancer progression vary widely

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Tumor sequencing of several different lung cancers and their surrounding tissue complicates the prevailing theory of linear lung cancer progression and offers new insights for management of this deadly cancer.

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