The protein SPOP, which is most frequently mutated in human prostate cancers, is a key regulator of androgen receptor activity that prevents uncontrolled growth of cells in the prostate and thus helps prevent cancer.
A new study shows that targeting a particular nuclear protein may provide an effective approach for treating triple-negative breast cancer.
Possible genetic origins of breast cancer that spreads to the brain have been uncovered, according to a first-of-its-kind study.
Small noncoding RNAs can be used to predict if a person has breast cancer, concluded researchers who contributed to The Cancer Genome Atlas (TCGA) project.
Concerns related to direct-to-consumer genomic testing include lack of evidence for association studies being appropriate as screening tests.
By combining a zebrafish model of liver cancer with data from human tumors, researchers hope to identify potential genes of interest that can be targeted for new treatments for hepatocellular carcinoma.
Research has not only shown that HER2-positive breast cancer can be classified into four different subtypes, but has also unmasked a subtype showing both a greater response to and increased benefit from chemotherapy and anti-HER2 therapy.
Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and then delivers those drugs to separate parts of the cancer cell where they will be most effective.
Researchers from Boston, Massachusetts; Mexico; and Norway have completed a comprehensive genomic analysis of cervical cancer in two patient populations.
The use of chimeric antigen receptor (CAR) cell engineering was described in several studies presented at the 2013 ASH Annual Meeting in New Orleans.
The metabolic profile of cancer cells can be used to develop therapies and identify biomarkers associated with cancer outcome. New research has discovered an association between the oncometabolite 2-HG levels, DNA methylation patterns, and breast cancer prognosis.
Modulating the hormonal environment in which endometrial cancers grow could make tumors significantly more sensitive to a new class of drugs known as poly(ADP-ribose) polymerase (PARP) inhibitors, according to new research.
Critical insights into how melanoma tumors resist BRAF inhibitors were gained from two back-to-back studies. Two key areas are the cell-signaling pathways BRAF-mutant melanoma cells use to become resistant to inhibitor drugs and to evolve and develop drug resistance.
Data from The Cancer Genome Atlas categorizes colorectal cancers and paves the way for the development of targeted therapies.
A new study is using genomic sequencing to develop customized treatments for men with castration-resistant prostate cancer.
An inherited gene variation has been linked to a nearly fourfold increased risk of developing a pediatric acute lymphoblastic leukemia subtype that is associated with a poor outcome.
Researchers have isolated and characterized the progenitor cells that give rise to malignant hepatocellular carcinoma tumors long before the actual tumors can be detected.
Both treatment and survival are improved when a tumor whose primary site is unknown has its molecular profile identified.
When 96 pilocytic astrocytomas were analyzed by whole-genome sequencing, all had MAPK-pathway alterations. This indicates that pilocytic astrocytoma is predominantly a single-pathway disease.
Lung cancer in women who have never smoked is more frequently associated with EGFR mutations and estrogen receptor overexpression, according to a new study.
A group of patients with early-stage, invasive breast cancer who do not benefit from neoadjuvant chemotherapy have been identified by molecular subtyping.
The Cancer Genome Atlas has the potential to generate unprecedented amounts of data on the major cancers and subtypes of cancer.
Improved understanding of how to integrate the results into the treatment planning process is changing the course of treatment for some patients.
Next generation genomic analysis has determined that some of the more aggressive prostate cancers have similar genetic origins, according to a recent publication
Four newly identified genetic variants are associated with an increased risk of testicular cancer, according to a new study that examined the genomes of over 13,000 men.
Findings from a new genome study could enhance current pathology methods in endometrial cancer and help discern types of endometrial tumors.
Sequencing of 57 prostate cancer genomes found that cancer gains a powerful advantage with abrupt intervals of complex, large-scale DNA reshuffling. This process has been dubbed punctuated cancer evolution.
This activity from myCME offers a review of groundbreaking molecular research and novel treatment options for patients with NSCLC.
Is CYP2D6 genotyping for tamoxifen (Nolvadex) sensitivity before use of the drug beneficial?
Mutations in four genes never before associated with colorectal cancer have been found to raise a person's risk for the disease by up to 40%.
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