Genetic Testing

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

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Rapid, robust, and affordable genetic testing for patients with ovarian cancer that allows a much larger portion of patients to benefit from personalized cancer management and their relatives to benefit from preventive strategies can be achieved.

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

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Disparities in cancer risk management among BRCA carriers across a diverse sample of young black, Hispanic, and non-Hispanic white breast cancer survivors underscores that "the benefit from genetic testing comes from acting on the test results," not just the testing itself, a study presented at the ASCO 2016 Annual Meeting concluded.

Participants Understand Implications of Multiplex Gene Testing for Inherited Cancer Risk

Participants Understand Implications of Multiplex Gene Testing for Inherited Cancer Risk

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Multiplex gene testing of diverse patients has found that patients who test positive advise relatives to test, "suggesting that participants understood the implications of test results," according to results of a planned interim analysis of a prospective trial presented at the ASCO 2016 Annual Meeting.

Large Germline Databases Needed to Mitigate Ethnic Disparities

Large Germline Databases Needed to Mitigate Ethnic Disparities

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"In the absence of patient-matched germline data, large germline databases are required in analysis workflows to minimize false positive mutation calling and mitigate ethnic disparities," a study presented at the ASCO 2016 Annual Meeting concluded.

Telephone Disclosure of Genetic Tests for Cancer Susceptibility Can Increase Satisfaction

Telephone Disclosure of Genetic Tests for Cancer Susceptibility Can Increase Satisfaction

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Results showed that telephone disclosure was not worse than in-person disclosure for general and state anxiety.

No Clinical Benefit to Expanding Gene Panel Beyond Ovarian and Breast Cancer Genes in High-risk Women

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Expanding a panel of tested genes beyond the known breast and ovarian cancer-specific genes in patients with breast and ovarian cancer did not confer any clinical benefit.

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

An analysis of test results can help women who won't benefit from additional treatment avoid potential side effects.

Genetic Testing for BRCA Gene Mutations Increasing Among Younger Women With Breast Cancer

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Among women age 40 years or younger, rates of genetic testing for BRCA1 and BRCA2 mutations have increased, according to a recent study.

Young patients with HER2+ breast cancer and no family history have low risk of carrying high risk genes

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A recent study examined genetic susceptibility in younger patients diagnosed with HER2+ breast cancer.

Stool DNA Test Is Proven an Accurate Screen for Colorectal Cancer in a High-Risk Population

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A stool DNA test for colorectal cancer was found to be an accurate noninvasive screening option for Alaska Native people, a population with one of the highest rates of colorectal cancer in the world, according to a recent study.

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

Blood Test Can Guide Treatment Sequencing for Pancreatic Cancer

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A widely available, inexpensive blood test can predict outcomes and guide treatment in pancreatic cancer; however, only 1 in 5 US patients with the disease have the blood test.

Genetic Variants Indicate 10-fold Increased Risk of Testicular Cancer

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A new study has uncovered four new genetic variants associated with increased risk of testicular cancer. Testing for these and all 21 previously identified variants using genetic sequencing identified men at higher risk of testicular cancer.

Use of chemotherapy is inverse to disease risk in patients with breast cancer when genetic assay is used

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Use of the 21-gene recurrence test score was associated with lower chemotherapy use in high-risk patients and greater use of chemotherapy in low-risk patients compared with not using the test score among a large group of Medicare beneficiaries, according to a recent investigation.

Multigene panel tests may identify less common harmful mutations in moderate-risk genes

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Multigene testing of women negative for BRCA1 and BRCA2 uncovered other harmful genetic mutations.

Personal genome diagnostics study shows limitations of tumor-only sequencing for cancer

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New research indicates that many genetic alterations identified using tumor-only sequencing are not actually associated with the cancer, but instead reflect inherited germline mutations already present in the normal cells of the person.

Genetic testing should be accessible to all women with ovarian cancer

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Women with ovarian cancer should be tested for BRCA1 and BRCA2 gene mutations, regardless of their family history.

Treatment for advanced lung cancer often initiated without genetic testing results

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Near one quarter of patients with advanced lung cancer in Europe, Asia, and the United States are not receiving EGFR test results before being started on treatment, researchers found.

One-third of women with breast cancer are concerned about genetic risk

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For many women with breast cancer, there is concern about the genetic risk of developing other cancers themselves or of a loved one developing cancer.

Most cancer patients want tumor profiling, but have mixed feelings about other genetic information the tests may reveal

Most cancer patients want tumor profiling, but have mixed feelings about other genetic information the tests may reveal

A majority of patients with cancer desire tumor profiling, even if the test would reveal risks for other genetic diseases.

Call for genetic cancer testing to include normal tissue

Call for genetic cancer testing to include normal tissue

Current practice of only focusing on tumor samples in genetic tests might adversely affect care, according to some researchers.

Genetic Testing for Hereditary Cancer Syndromes (Fact Sheet)

Genetic Testing for Hereditary Cancer Syndromes (Fact Sheet)

This fact sheet reviews genetic testing for cancer risk, including currently available genetic tests, recommendations for testing, positive and negative result definitions, and direct-to-consumer tests.

Breast cancer patients want, but may not get, genetic risk discussion

Breast cancer patients want, but may not get, genetic risk discussion

Although many patients with breast cancer are concerned about genetic risk for other cancer types, almost half don't have conversation with doctor about potential for future problems.

Poll: Many Americans interested in genetic testing

Poll: Many Americans interested in genetic testing

But researchers wonder if everyone is adept at accurately interpreting genetic test results.

Genetics training improves care and reduces unnecessary testing

Genetics training improves care and reduces unnecessary testing

Counseling from a health care professional trained in genetics before genetic testing takes place may improve the quality of health care.

Tool Assesses Psychosocial Problems in Genetic Counseling

Tool Assesses Psychosocial Problems in Genetic Counseling

A questionnaire can help counselors address psychosocial issues in genetic counseling for cancer.

Cultured circulating tumor cells reveal genetic profile of breast cancer cells

Cultured circulating tumor cells reveal genetic profile of breast cancer cells

Researchers have created a microchip device that can capture circulating tumor cells, in order to track ongoing genetic mutation within a tumor.

Health care professionals trained in genetics may improve quality of care and reduce unnecessary testing

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Counseling from a health care professional trained in genetics before genetic testing takes place may improve the quality of health care and help reduce unnecessary testing.

Barriers to obtaining gene expression profiling tests increase their perceived value among patients

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Barriers to obtaining gene expression profiling tests increased their perceived importance among patients with early breast cancer (estrogen-receptor positive [ER+], human epidermal growth-factor receptor 2 negative [HER2-], and node negative) who were deciding whether to have chemotherapy after surgery, according to a new study from Canada.

A few circulating tumor cells can indicate metastasis risk

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A simple, noninvasive blood test matched with state-of-the-art molecular imaging of individual cells could help oncologists understand their patients' chances of survival.

Biomarkers in seminal fluid indicate presence and severity of prostate cancer

Biomarkers in seminal fluid indicate presence and severity of prostate cancer

Improved diagnosis and management of prostate cancer could result from research at the research at the University of Adelaide, which has discovered that seminal fluid (semen) contains biomarkers for the disease.

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