Genes identified for ovarian cancer prognosis

Share this article:
Genes Identified for Ovarian Cancer Prognosis
Genes Identified for Ovarian Cancer Prognosis

FRIDAY, April 13 (HealthDay News) -- Bimodal genes, or molecular on/off switches, can distinguish clinically relevant subtypes of ovarian cancer and provide ideal targets for diagnostic and prognostic testing, according to a study published online April 11 in the Journal of Molecular Diagnostics.

Dawn N. Kernagis, from Duke University in Durham, N.C., and colleagues used a bimodal discovery algorithm in conjunction with a publicly available ovarian cancer expression microarray data set on 285 ovarian tumors (246 malignant serous [MS] tumors, 20 endometrioid [EM] tumors, 18 low malignant potential [LMP] tumors, and one malignant adenocarcinoma).

The researchers found that robust bimodal expression patterns were identified in genes across all ovarian tumor types and within selected subtypes. Differential expression between LMP versus MS and EM was shown in 73 bimodal genes; 22 bimodal genes distinguished MS from EM; and 14 genes were significantly associated with survival among MS tumors. For patients with a favorable survival score, derived from a combination of these genes, median survival was significantly longer, 65 versus 29 months (hazard ratio, 0.4221). The survival score was validated using two independent data sets [high-grade, advanced-stage serous and advanced-stage ovarian tumors].

"We conclude that genes with bimodal expression patterns not only define clinically relevant molecular subtypes of ovarian carcinoma but also provide ideal targets for translation into the clinical laboratory," write the authors.

Full Text (subscription or payment may be required)

This article originally appeared here.
Share this article:
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in Daily Oncology News

Lung infections may lessen chance of detecting lung cancer

Lung infections may lessen chance of detecting lung ...

Certain conditions make it harder to reliably detect tumors, and regions with locally-endemic infectious lung diseases pose an added hurdle for lung cancer detection.

Report identifies new directions for U.S. health care

Report identifies new directions for U.S. health care

A report from the IMS Institute for Healthcare Informatics notes 10 "harbingers of change" expected to alter the delivery of health care and medicine use over the next decade.

E-cigarettes don't help cancer patients stop smoking

E-cigarettes don't help cancer patients stop smoking

Smokers with cancer who used e-cigarettes along with traditional cigarettes were more dependent on nicotine, and the long-term safety of the devices still unclear, researchers caution.