Gemcitabine

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

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Combining a laboratory ultrasound technique called sonoporation with the commercially available chemotherapy compound gemcitabine increases the porosity of pancreatic cells with microbubbles and helps get the drug into cancer cells.

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

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Adjuvant gemcitabine plus capecitabine significantly improved overall survival compared with gemcitabine monotherapy in patients with pancreatic ductal adenocarcinoma, according to results of the ESPAC-4 trial presented at the ASCO 2016 Annual Meeting.

Concurrent Radiotherapy With Oral Fluoropyrimidine Versus Gemcitabine in Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis

Concurrent Radiotherapy With Oral Fluoropyrimidine Versus Gemcitabine in Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis

[OncoTargets and Therapy] This research evaluates the efficacy and toxicities of oral FU-based CRT compared with GEM-based CRT for the treatment of locally advanced pancreatic cancer (LAPC).

Artificial Intelligence May Better Predict Response in Breast Cancer Treatment

Artificial Intelligence May Better Predict Response in Breast Cancer Treatment

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Researchers are working on a way to use artificial intelligence to predict a patient's response to two common chemotherapy drugs used to treat breast cancer: paclitaxel and gemcitabine.

Drug sequence with gemcitabine

Drug sequence with gemcitabine

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When giving gemcitabine (Gemzar) and cisplatin (Platinol), is it better to give gemcitabine first to reduce myelosuppression with every indication?

CT scans pinpoint gemcitabine response in pancreatic cancer

CT scans pinpoint gemcitabine response in pancreatic cancer

Transport properties identified on routine CT scans correlate with clinically relevant end points for patients with pancreatic ductal adenocarcinoma (PDAC) who receive preoperative gemcitabine chemoradiotherapy.

Nab-paclitaxel plus gemcitabine up pancreatic cancer survival

Nab-paclitaxel plus gemcitabine up pancreatic cancer survival

For patients with metastatic pancreatic cancer, treatment with albumin-bound paclitaxel (nab-paclitaxel) plus gemcitabine is more effective than gemcitabine alone.

Pancreatic cancer survival improved by gemcitabine

Pancreatic cancer survival improved by gemcitabine

Adjuvant treatment also improves disease-free survival compared with observation

Combination therapy improves survival in biliary tract cancer

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Patients with advanced biliary cancer treated with cisplatin plus gemcitabine experience a significant survival advantage without added toxicity, according to a study published in The New England Journal of Medicine (2010;362(14):1273-1281).

Chemotherapy combination effectively treats patients with endometrial cancer

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Women with advanced or recurrent endometrial cancer respond to gemcitabine and cisplatin when used together, according to a study presented at the Society of Gynecologic Oncologists' 41st Annual Meeting.

Use of an enzyme inhibitor in treating pancreatic cancer

Resistance to chemotherapy is one of the greatest challenges in pancreatic cancer treatment. However, US researchers have found that inhibiting the enzyme TAK-1 can overcome this.

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