Gastrointestinal Cancer

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

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A study on a cohort of women enrolled in the WHI-OS shows that those with a history of periodontal disease had a higher risk for developing some cancers.

Increases in Liver Cancer Incidence Influenced by Higher Rates of Comorbidities

Increases in Liver Cancer Incidence Influenced by Higher Rates of Comorbidities

A new report from ACS describes trends in liver cancer and the factors influencing the ongoing increase in incidence, particularly higher rates of HCV infection, obesity, and type 2 diabetes.

No Serious HRQOL Decline With FOLFOXIRI/Bevacizumab

No Serious HRQOL Decline With FOLFOXIRI/Bevacizumab

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Study compared FOLFOXIRI/bevacizumab and FOLFOX/bevacizumab in patients with metastatic colorectal cancer.

ACS Survivorship Guidelines for Healthy Behaviors Beneficial for Colon Cancer Survivors

ACS Survivorship Guidelines for Healthy Behaviors Beneficial for Colon Cancer Survivors

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Patients with stage III colon cancer who follow the ACS guidelines for a healthy lifestyle after adjuvant chemotherapy had longer disease-free survival and overall survival.

Consuming Tree Nuts Improves DFS, OS in Survivors of Colon Cancer

Consuming Tree Nuts Improves DFS, OS in Survivors of Colon Cancer

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Consumption of tree nuts is associated with significantly improved disease-free survival (DFS) and overall survival (OS) in survivors of stage III colon cancer who consume 2 or more servings per week.

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

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Precision Medicine Improves Pancreatic Cancer Treatment

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

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Cisplatin plus standard-of-care gemcitabine/nab-paclitaxel improved tumor shrinkage in patients with metastatic pancreatic cancer, according to a study by the HonorHealth Research Institute and the Translational Genomics Research Institute.

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

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Biopolymer codelivery of CAR T cells and stimulator of IFN genes directly to the surface of solid tumors more effectively reduced tumor size.

SEER Data Illustrates Trends in Gallbladder Cancer Incidence, Stage at Diagnosis

SEER Data Illustrates Trends in Gallbladder Cancer Incidence, Stage at Diagnosis

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Trends in SEER data from 1972 to 2009 show gallbladder cancer incidence decreasing in men, but late-stage disease at diagnosis for both sexes is increasing.

Survival Better for Hispanics, Blacks With Colorectal Cancer but HR-QoL Is Better for Whites

Survival Better for Hispanics, Blacks With Colorectal Cancer but HR-QoL Is Better for Whites

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Although median survival is longer for Hispanic and black patients compared with white patients, health-related QoL is poor for minority patients.

Research Shows iPS-ML/IFN-β Migrates to, Penetrate Liver Cancer Tumors

Research Shows iPS-ML/IFN-β Migrates to, Penetrate Liver Cancer Tumors

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Decreased liver tumor growth and improved survival in a mouse model were noted after injecting iPS-ML/IFN-β.

Exercise Improves Coping While Undergoing Chemotherapy for Advanced GI Cancer

Exercise Improves Coping While Undergoing Chemotherapy for Advanced GI Cancer

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Exercise helps patients with gastrointestinal cancer undergoing chemotherapy cope with their disease and treatment.

Colorectal Cancer in 2017: Incidence Rates Going Up in Younger Patients, Down in Older Patients

Colorectal Cancer in 2017: Incidence Rates Going Up in Younger Patients, Down in Older Patients

ACS colorectal cancer statistics show an overall decrease in incidence due to increases in screening rates; however, age-related incidence is trending up in younger persons, down in older persons.

SWOG Study Shows Robust, Longer Survival With Imatinib Therapy for GIST

SWOG Study Shows Robust, Longer Survival With Imatinib Therapy for GIST

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A phase 3 analysis of SWOG Intergroup Trial S0033 reveals that imatinib significantly extends survival in patients with GIST.

Short-Course Radiation With Delay to Surgery Improves Outcomes in Rectal Cancer

Short-Course Radiation With Delay to Surgery Improves Outcomes in Rectal Cancer

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Outcomes improved with short-course radiation and delay to surgery of 4 to 8 weeks.

Colorectal Cancer Risk Higher With Poor Metabolic Health vs Increased Weight

Colorectal Cancer Risk Higher With Poor Metabolic Health vs Increased Weight

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Women with poor metabolic health have a greater risk of colorectal cancer than those with increased weight.

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

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Clinical trials show pembrolizumab active against mucosal melanoma, extends survival in bladder cancer.

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

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An investigation into whether onset or worsening of diabetes causes pancreatic cancer or vice versa was presented at the 2017 European Cancer Congress.

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

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Research presented at the 2017 European Cancer Congress describes the potential of a noninvasive diagnostic test for esophageal and gastric cancers that measures chemicals in the breath.

Chemo May Be Overused Among Young, Middle-aged Adults With Colon Cancer

Chemo May Be Overused Among Young, Middle-aged Adults With Colon Cancer

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Chemotherapy may be overused among young and middle-aged adults with colon cancer, with the addition of adjuvant chemotherapy not resulting in a matched survival benefit.

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

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PDX1 appears to have distinct roles at different stages of pancreatic cancer development.

Treatment for Young Adults With GIST May Differ From Older Adults GIST Patients

Treatment for Young Adults With GIST May Differ From Older Adults GIST Patients

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Researchers conduct a retrospective cohort study of histologically diagnosed gastrointestinal stromal tumors in the Surveillance, Epidemiology, and End Results (SEER) database.

Hepatitis C Virus Associated With Increased Risk of Variety of Cancers

Hepatitis C Virus Associated With Increased Risk of Variety of Cancers

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Researchers have found that hepatitis C virus infection is associated with an elevated risk for developing bile duct cancers and diffuse large B-cell lymphoma.

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

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In a phase 3 trial, researchers determined if weekly nab-paclitaxel was noninferior to weekly solvent-based paclitaxel with respect to overall survival in patients requiring second-line treatment for advanced gastric cancer.

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

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Findings are presented from an open-label NETTER-1 clinical trial evaluating the efficacy and safety of 177Lu-Dotatate in patients with advanced midgut neuroendocrine tumors who have experienced disease progression during first-line treatment with a somatostatin analogue.

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

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Drug-drug interaction between capecitabine and common heartburn medications has a negative effect on progression-free survival and overall survival in patients with GI cancer.

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

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Given the frequency of gene mutations in patients with early-onset CRC, genetic counseling and testing could be considered for this population.

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

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Adding the mesenchymal-epithelial transition (MET) antibody onartuzumab did not significantly improve clinical outcomes.

Study Helps to Clarify Navigator Role in Colonoscopy Screening

Study Helps to Clarify Navigator Role in Colonoscopy Screening

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Survey data from patients receiving care at Boston Medical Center who were navigated for colonoscopy screening illustrates how patients value the services of oncology patient navigators.

Prediagnostic Wine Consumption May Improve Survival After CRC

Prediagnostic Wine Consumption May Improve Survival After CRC

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A possible association between moderate to heavy alcohol consumption has been shown in previous studies. In this study, investigators examined the relationship between alcohol consumption and colorectal cancer survival remains unclear.

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