Gastrointestinal Cancer

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

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Adding the mesenchymal-epithelial transition (MET) antibody onartuzumab did not significantly improve clinical outcomes.

Study Helps to Clarify Navigator Role in Colonoscopy Screening

Study Helps to Clarify Navigator Role in Colonoscopy Screening

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Survey data from patients receiving care at Boston Medical Center who were navigated for colonoscopy screening illustrates how patients value the services of oncology patient navigators.

Prediagnostic Wine Consumption May Improve Survival After CRC

Prediagnostic Wine Consumption May Improve Survival After CRC

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A possible association between moderate to heavy alcohol consumption has been shown in previous studies. In this study, investigators examined the relationship between alcohol consumption and colorectal cancer survival remains unclear.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

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Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

Novel Colonoscopy Prep Is Poised to Improve Screening Rates for Colon Cancer

Novel Colonoscopy Prep Is Poised to Improve Screening Rates for Colon Cancer

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Novel preparation formulation is as effective and safe as current colon prep for colonoscopy. Plus, study participants gave the prep experience a high satisfaction rating.

PPIs Negatively Impact Outcomes of Patients Treated With Capecitabine

PPIs Negatively Impact Outcomes of Patients Treated With Capecitabine

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Because gastric acid suppressants, such as proton pump inhibitors, affect the absorption of some oral cancer medications, researchers sought to determine if proton pump inhibitors impair capecitabine efficacy.

Kinase Inhibitors: Managing Side Effects in GI Cancers

Kinase Inhibitors: Managing Side Effects in GI Cancers

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A review of adverse effects and recommended management for 3 kinase inhibitors indicated for the treatment of gastrointestinal cancers.

Rolapitant Improves CINV Prevention in Patients With GI Cancers

Rolapitant Improves CINV Prevention in Patients With GI Cancers

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Adding rolapitant to a 5-HT3 receptor antagonist and dexamethasone significantly improved the prevention of CINV in patients with GI and CRC cancers receiving highly or moderately emetogenic chemotherapy.

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

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Applying evolutionary theory improves the accuracy of predicting in which patients Barrett's esophagus will progress to esophageal adenocarcinoma.

Increasing Dietary Omega-3 Intake After Colorectal Cancer Diagnosis Improves Survival

Increasing Dietary Omega-3 Intake After Colorectal Cancer Diagnosis Improves Survival

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Lifestyle and dietary measures for preventing colorectal cancer are extensively studied; however, in this study, researchers looked at a dietary measure that improved survival for patients after diagnosis.

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

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Poor compliance to NCCN guidelines for adjuvant chemotherapy appears to be associated with poorer overall survival.

Metformin Use May Improve Survival in Patients With CRC, Diabetes

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Research indicates that metformin can confer improved survival for patients with colorectal cancer that also have diabetes.

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

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Research findings reveal the mechanism by which obesity increases inflammation and desmoplasia in the most frequent type of pancreatic cancer, using mouse models and human tissue samples.

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

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Quality of life is significantly improved for patients with pancreatic cancer when systematic palliative care is administered vs on-demand palliative care.

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

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Genetic biomarkers from tumor DNA circulating in the bloodstream could indicate the risk for recurrence of colorectal cancer and the efficacy of chemotherapy after surgery.

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

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The multikinase inhibitor regorafenib significantly improved overall survival rates compared to placebo in patients with hepatocellular carcinoma, according to data from the phase 3 RESORCE trial.

Computer Algorithm Matches Skilled Specialists in Detecting Early Esophageal Cancer

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Using a computer algorithm to scan images of the esophagus for signs of early esophageal cancer is nearly as accurate as top specialists.

In Stage II Colon Cancer, Adjuvant Chemo is Associated With Improved OS

In Stage II Colon Cancer, Adjuvant Chemo is Associated With Improved OS

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Adjuvant chemotherapy is associated with improved overall survival in patients with stage II colon cancer regardless of treatment regimen, patient age, or high-risk pathologic risk features.

More Older Patients With Comorbidities Are Receiving Therapy for mCRC

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The proportion of older patients with comorbidities receiving treatment for metastatic colorectal cancer (mCRC) has increased over the last 2 decades despite the overall percentage of older adults being treated remaining low.

Scalding Beverages Might Lead to Esophageal Cancer

Scalding Beverages Might Lead to Esophageal Cancer

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Drinking scalding coffee, tea, or yerba mate might increase the risk of developing esophageal cancer according to the World Health Organization. Beverages hotter than 149°F (65°C) might increase the risk of developing esophageal cancer.

Aspirin Use Found to Prevent Cholangiocarcinoma

Aspirin Use Found to Prevent Cholangiocarcinoma

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Aspirin's anti-inflammatory action is protective against another aggressive cancer: cholangiocarcinoma. Furthermore, it is beneficial regardless of daily use or dose.

Resectable Cholangiocarcinoma: Reviewing the Role of Adjuvant Strategies

Resectable Cholangiocarcinoma: Reviewing the Role of Adjuvant Strategies

[Clinical Medicine Insights: Oncology] This research examines the role of adjuvant chemotherapy in resectable bile duct cancer treatment.

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

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Metastatic capabilities of pancreatic cancer might arise before tumors even form. Metastasis and advanced stage of disease at diagnosis are attributed to low survival rates for pancreatic cancer.

Gene Activity Predicts Patient Response to Inhibitor Treatment for Stomach Cancer

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Measurements of copies of a single gene circulating in the bloodstream allowed scientists to identify patients with stomach cancer who were most likely to respond to treatment.

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

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Combining a laboratory ultrasound technique called sonoporation with the commercially available chemotherapy compound gemcitabine increases the porosity of pancreatic cells with microbubbles and helps get the drug into cancer cells.

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

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Despite the increased risk, patients whose pancreatic cancer tumor has grown to encompass critical blood vessels can be candidates for surgery. Data on efforts to fine-tune a protocol for these patients were presented at the SSAT 57th Annual Meeting.

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

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Adjuvant gemcitabine plus capecitabine significantly improved overall survival compared with gemcitabine monotherapy in patients with pancreatic ductal adenocarcinoma, according to results of the ESPAC-4 trial presented at the ASCO 2016 Annual Meeting.

No Benefit for Chemoradiotherapy vs Chemotherapy After Resectable Gastric Cancer

No Benefit for Chemoradiotherapy vs Chemotherapy After Resectable Gastric Cancer

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First results from the phase 3 CRITICS study found no significant difference in overall survival between postoperative chemotherapy and chemoradiotherapy in patients with resectable gastric cancer, according to a study presented at the ASCO 2016 Annual Meeting.

Survival for Patients With Liver Cancer Differs by Race

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A study of nearly 1000 patients with HCC found that black patients with the disease had a 33% greater risk of death compared with non-Hispanic whites.

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

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Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

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