Gastrointestinal Cancer

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

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Clinical trials show pembrolizumab active against mucosal melanoma, extends survival in bladder cancer.

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

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An investigation into whether onset or worsening of diabetes causes pancreatic cancer or vice versa was presented at the 2017 European Cancer Congress.

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

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Research presented at the 2017 European Cancer Congress describes the potential of a noninvasive diagnostic test for esophageal and gastric cancers that measures chemicals in the breath.

Chemo May Be Overused Among Young, Middle-aged Adults With Colon Cancer

Chemo May Be Overused Among Young, Middle-aged Adults With Colon Cancer

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Chemotherapy may be overused among young and middle-aged adults with colon cancer, with the addition of adjuvant chemotherapy not resulting in a matched survival benefit.

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

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PDX1 appears to have distinct roles at different stages of pancreatic cancer development.

Treatment for Young Adults With GIST May Differ From Older Adults GIST Patients

Treatment for Young Adults With GIST May Differ From Older Adults GIST Patients

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Researchers conduct a retrospective cohort study of histologically diagnosed gastrointestinal stromal tumors in the Surveillance, Epidemiology, and End Results (SEER) database.

Hepatitis C Virus Associated With Increased Risk of Variety of Cancers

Hepatitis C Virus Associated With Increased Risk of Variety of Cancers

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Researchers have found that hepatitis C virus infection is associated with an elevated risk for developing bile duct cancers and diffuse large B-cell lymphoma.

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

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In a phase 3 trial, researchers determined if weekly nab-paclitaxel was noninferior to weekly solvent-based paclitaxel with respect to overall survival in patients requiring second-line treatment for advanced gastric cancer.

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

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Findings are presented from an open-label NETTER-1 clinical trial evaluating the efficacy and safety of 177Lu-Dotatate in patients with advanced midgut neuroendocrine tumors who have experienced disease progression during first-line treatment with a somatostatin analogue.

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

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Drug-drug interaction between capecitabine and common heartburn medications has a negative effect on progression-free survival and overall survival in patients with GI cancer.

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

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Given the frequency of gene mutations in patients with early-onset CRC, genetic counseling and testing could be considered for this population.

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

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Adding the mesenchymal-epithelial transition (MET) antibody onartuzumab did not significantly improve clinical outcomes.

Study Helps to Clarify Navigator Role in Colonoscopy Screening

Study Helps to Clarify Navigator Role in Colonoscopy Screening

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Survey data from patients receiving care at Boston Medical Center who were navigated for colonoscopy screening illustrates how patients value the services of oncology patient navigators.

Prediagnostic Wine Consumption May Improve Survival After CRC

Prediagnostic Wine Consumption May Improve Survival After CRC

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A possible association between moderate to heavy alcohol consumption has been shown in previous studies. In this study, investigators examined the relationship between alcohol consumption and colorectal cancer survival remains unclear.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

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Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

Novel Colonoscopy Prep Is Poised to Improve Screening Rates for Colon Cancer

Novel Colonoscopy Prep Is Poised to Improve Screening Rates for Colon Cancer

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Novel preparation formulation is as effective and safe as current colon prep for colonoscopy. Plus, study participants gave the prep experience a high satisfaction rating.

PPIs Negatively Impact Outcomes of Patients Treated With Capecitabine

PPIs Negatively Impact Outcomes of Patients Treated With Capecitabine

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Because gastric acid suppressants, such as proton pump inhibitors, affect the absorption of some oral cancer medications, researchers sought to determine if proton pump inhibitors impair capecitabine efficacy.

Kinase Inhibitors: Managing Side Effects in GI Cancers

Kinase Inhibitors: Managing Side Effects in GI Cancers

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A review of adverse effects and recommended management for 3 kinase inhibitors indicated for the treatment of gastrointestinal cancers.

Rolapitant Improves CINV Prevention in Patients With GI Cancers

Rolapitant Improves CINV Prevention in Patients With GI Cancers

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Adding rolapitant to a 5-HT3 receptor antagonist and dexamethasone significantly improved the prevention of CINV in patients with GI and CRC cancers receiving highly or moderately emetogenic chemotherapy.

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

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Applying evolutionary theory improves the accuracy of predicting in which patients Barrett's esophagus will progress to esophageal adenocarcinoma.

Increasing Dietary Omega-3 Intake After Colorectal Cancer Diagnosis Improves Survival

Increasing Dietary Omega-3 Intake After Colorectal Cancer Diagnosis Improves Survival

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Lifestyle and dietary measures for preventing colorectal cancer are extensively studied; however, in this study, researchers looked at a dietary measure that improved survival for patients after diagnosis.

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

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Poor compliance to NCCN guidelines for adjuvant chemotherapy appears to be associated with poorer overall survival.

Metformin Use May Improve Survival in Patients With CRC, Diabetes

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Research indicates that metformin can confer improved survival for patients with colorectal cancer that also have diabetes.

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

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Research findings reveal the mechanism by which obesity increases inflammation and desmoplasia in the most frequent type of pancreatic cancer, using mouse models and human tissue samples.

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

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Quality of life is significantly improved for patients with pancreatic cancer when systematic palliative care is administered vs on-demand palliative care.

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

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Genetic biomarkers from tumor DNA circulating in the bloodstream could indicate the risk for recurrence of colorectal cancer and the efficacy of chemotherapy after surgery.

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

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The multikinase inhibitor regorafenib significantly improved overall survival rates compared to placebo in patients with hepatocellular carcinoma, according to data from the phase 3 RESORCE trial.

Computer Algorithm Matches Skilled Specialists in Detecting Early Esophageal Cancer

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Using a computer algorithm to scan images of the esophagus for signs of early esophageal cancer is nearly as accurate as top specialists.

In Stage II Colon Cancer, Adjuvant Chemo is Associated With Improved OS

In Stage II Colon Cancer, Adjuvant Chemo is Associated With Improved OS

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Adjuvant chemotherapy is associated with improved overall survival in patients with stage II colon cancer regardless of treatment regimen, patient age, or high-risk pathologic risk features.

More Older Patients With Comorbidities Are Receiving Therapy for mCRC

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The proportion of older patients with comorbidities receiving treatment for metastatic colorectal cancer (mCRC) has increased over the last 2 decades despite the overall percentage of older adults being treated remaining low.

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