Gastrointestinal Cancer section

Gastrointestinal Cancer News & Features

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

In a phase 3 trial, researchers determined if weekly nab-paclitaxel was noninferior to weekly solvent-based paclitaxel with respect to overall survival in patients requiring second-line treatment for advanced gastric cancer.

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

Findings are presented from an open-label NETTER-1 clinical trial evaluating the efficacy and safety of 177Lu-Dotatate in patients with advanced midgut neuroendocrine tumors who have experienced disease progression during first-line treatment with a somatostatin analogue.

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

Drug-drug interaction between capecitabine and common heartburn medications has a negative effect on progression-free survival and overall survival in patients with GI cancer.

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

Given the frequency of gene mutations in patients with early-onset CRC, genetic counseling and testing could be considered for this population.

Selumetinib + MK-2206 Fails to Improve Survival vs mFOLFOX in Pancreatic Cancer

Selumetinib + MK-2206 Fails to Improve Survival vs mFOLFOX in Pancreatic Cancer

Seluminitinib in combination with an AKT inhibitor did not improve survival compared with modified FOLFOX in previously treated metastatic pancreatic cancer.

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