Utilization and Trends in Palliative Therapy for Stage IV Pancreatic Adenocarcinoma Patients: A U.S. Population-based Study

Utilization and Trends in Palliative Therapy for Stage IV Pancreatic Adenocarcinoma Patients: A U.S. Population-based Study

[Journal of Gastrointestinal Oncology] This research examined patients who presented with metastatic pancreatic adenocarcinoma at diagnosis, and their patterns of palliative care utilization.

Childhood-Onset IBD May Increase Adult Cancer Risk

Childhood-Onset IBD May Increase Adult Cancer Risk

Researchers think chronic inflammation in gastrointestinal tract may increase the future risk of gastrointestinal cancers, lymphoid neoplasms, and skin cancer.

CAR, PNI Levels Correlate with Outcomes in Pancreatic Cancer

CAR, PNI Levels Correlate with Outcomes in Pancreatic Cancer

An association was found between low PNI/high CAR levels and poor outcomes in operable pancreatic ductal adenocarcinoma, even in patients who undergo curative resection.

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

A study on a cohort of women enrolled in the WHI-OS shows that those with a history of periodontal disease had a higher risk for developing some cancers.

Increases in Liver Cancer Incidence Influenced by Higher Rates of Comorbidities

Increases in Liver Cancer Incidence Influenced by Higher Rates of Comorbidities

A new report from ACS describes trends in liver cancer and the factors influencing the ongoing increase in incidence, particularly higher rates of HCV infection, obesity, and type 2 diabetes.

Navigating Colorectal and Pancreatic Cancer Patients in a Multidisciplinary Cancer Center

Navigating Colorectal and Pancreatic Cancer Patients in a Multidisciplinary Cancer Center

By identifying incidence, prevalence, and risk factors for colorectal and pancreatic cancer in our communities, nurse navigators can develop screening and prevention programs to better serve these populations.

No Serious HRQOL Decline With FOLFOXIRI/Bevacizumab

No Serious HRQOL Decline With FOLFOXIRI/Bevacizumab

Study compared FOLFOXIRI/bevacizumab and FOLFOX/bevacizumab in patients with metastatic colorectal cancer.

ACS Survivorship Guidelines for Healthy Behaviors Beneficial for Colon Cancer Survivors

ACS Survivorship Guidelines for Healthy Behaviors Beneficial for Colon Cancer Survivors

Patients with stage III colon cancer who follow the ACS guidelines for a healthy lifestyle after adjuvant chemotherapy had longer disease-free survival and overall survival.

Consuming Tree Nuts Improves DFS, OS in Survivors of Colon Cancer

Consuming Tree Nuts Improves DFS, OS in Survivors of Colon Cancer

Consumption of tree nuts is associated with significantly improved disease-free survival (DFS) and overall survival (OS) in survivors of stage III colon cancer who consume 2 or more servings per week.

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

Genome-Informed Treatment Improves Survival in Pancreatic Cancer

Precision Medicine Improves Pancreatic Cancer Treatment

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

Cisplatin plus standard-of-care gemcitabine/nab-paclitaxel improved tumor shrinkage in patients with metastatic pancreatic cancer, according to a study by the HonorHealth Research Institute and the Translational Genomics Research Institute.

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

Biopolymer codelivery of CAR T cells and stimulator of IFN genes directly to the surface of solid tumors more effectively reduced tumor size.

SEER Data Illustrates Trends in Gallbladder Cancer Incidence, Stage at Diagnosis

SEER Data Illustrates Trends in Gallbladder Cancer Incidence, Stage at Diagnosis

Trends in SEER data from 1972 to 2009 show gallbladder cancer incidence decreasing in men, but late-stage disease at diagnosis for both sexes is increasing.

Survival Better for Hispanics, Blacks With Colorectal Cancer but HR-QoL Is Better for Whites

Survival Better for Hispanics, Blacks With Colorectal Cancer but HR-QoL Is Better for Whites

Although median survival is longer for Hispanic and black patients compared with white patients, health-related QoL is poor for minority patients.

Research Shows iPS-ML/IFN-β Migrates to, Penetrate Liver Cancer Tumors

Research Shows iPS-ML/IFN-β Migrates to, Penetrate Liver Cancer Tumors

Decreased liver tumor growth and improved survival in a mouse model were noted after injecting iPS-ML/IFN-β.

Exercise Improves Coping While Undergoing Chemotherapy for Advanced GI Cancer

Exercise Improves Coping While Undergoing Chemotherapy for Advanced GI Cancer

Exercise helps patients with gastrointestinal cancer undergoing chemotherapy cope with their disease and treatment.

Colorectal Cancer in 2017: Incidence Rates Going Up in Younger Patients, Down in Older Patients

Colorectal Cancer in 2017: Incidence Rates Going Up in Younger Patients, Down in Older Patients

ACS colorectal cancer statistics show an overall decrease in incidence due to increases in screening rates; however, age-related incidence is trending up in younger persons, down in older persons.

SWOG Study Shows Robust, Longer Survival With Imatinib Therapy for GIST

SWOG Study Shows Robust, Longer Survival With Imatinib Therapy for GIST

A phase 3 analysis of SWOG Intergroup Trial S0033 reveals that imatinib significantly extends survival in patients with GIST.

Short-Course Radiation With Delay to Surgery Improves Outcomes in Rectal Cancer

Short-Course Radiation With Delay to Surgery Improves Outcomes in Rectal Cancer

Outcomes improved with short-course radiation and delay to surgery of 4 to 8 weeks.

Colorectal Cancer Risk Higher With Poor Metabolic Health vs Increased Weight

Colorectal Cancer Risk Higher With Poor Metabolic Health vs Increased Weight

Women with poor metabolic health have a greater risk of colorectal cancer than those with increased weight.

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer

Clinical trials show pembrolizumab active against mucosal melanoma, extends survival in bladder cancer.

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

Onset or Rapid Worsening of Diabetes May Indicate Pancreatic Cancer

An investigation into whether onset or worsening of diabetes causes pancreatic cancer or vice versa was presented at the 2017 European Cancer Congress.

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

Research presented at the 2017 European Cancer Congress describes the potential of a noninvasive diagnostic test for esophageal and gastric cancers that measures chemicals in the breath.

Postoperative Gemcitabine Plus Capecitabine: A New Standard of Care for Pancreatic Cancer

Postoperative Gemcitabine Plus Capecitabine: A New Standard of Care for Pancreatic Cancer

Use of Adjuvant gemcitabine plus capecitabine for patients with pancreatic cancer who have undergone tumor resection resulted in a modest increase short-term survival.

Chemo May Be Overused Among Young, Middle-aged Adults With Colon Cancer

Chemo May Be Overused Among Young, Middle-aged Adults With Colon Cancer

Chemotherapy may be overused among young and middle-aged adults with colon cancer, with the addition of adjuvant chemotherapy not resulting in a matched survival benefit.

Cancer Stem Cell Research Suggests a New Approach to Treatment Resistance in Esophageal Cancer

Cancer Stem Cell Research Suggests a New Approach to Treatment Resistance in Esophageal Cancer

Researchers reveal that miR-17 appears to be important in driving esophageal tumor resistance to radiotherapy.

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

Study Raises Questions About PDX1 as a Potential Pancreatic Cancer Target

PDX1 appears to have distinct roles at different stages of pancreatic cancer development.

Treatment for Young Adults With GIST May Differ From Older Adults GIST Patients

Treatment for Young Adults With GIST May Differ From Older Adults GIST Patients

Researchers conduct a retrospective cohort study of histologically diagnosed gastrointestinal stromal tumors in the Surveillance, Epidemiology, and End Results (SEER) database.

Hepatitis C Virus Associated With Increased Risk of Variety of Cancers

Hepatitis C Virus Associated With Increased Risk of Variety of Cancers

Researchers have found that hepatitis C virus infection is associated with an elevated risk for developing bile duct cancers and diffuse large B-cell lymphoma.

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

Second-line Weekly Nab-paclitaxel Noninferior to Paclitaxel for Gastric Cancer

In a phase 3 trial, researchers determined if weekly nab-paclitaxel was noninferior to weekly solvent-based paclitaxel with respect to overall survival in patients requiring second-line treatment for advanced gastric cancer.

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

Lutetium-177 Dotatate Improves PFS in Advanced Midgut Carcinoid Tumors

Findings are presented from an open-label NETTER-1 clinical trial evaluating the efficacy and safety of 177Lu-Dotatate in patients with advanced midgut neuroendocrine tumors who have experienced disease progression during first-line treatment with a somatostatin analogue.

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

Drug-drug interaction between capecitabine and common heartburn medications has a negative effect on progression-free survival and overall survival in patients with GI cancer.

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

Multigene Panel Testing For Patients With Early-onset Colorectal Cancer

Given the frequency of gene mutations in patients with early-onset CRC, genetic counseling and testing could be considered for this population.

Selumetinib + MK-2206 Fails to Improve Survival vs mFOLFOX in Pancreatic Cancer

Selumetinib + MK-2206 Fails to Improve Survival vs mFOLFOX in Pancreatic Cancer

Seluminitinib in combination with an AKT inhibitor did not improve survival compared with modified FOLFOX in previously treated metastatic pancreatic cancer.

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma

Adding the mesenchymal-epithelial transition (MET) antibody onartuzumab did not significantly improve clinical outcomes.

Study Helps to Clarify Navigator Role in Colonoscopy Screening

Study Helps to Clarify Navigator Role in Colonoscopy Screening

Survey data from patients receiving care at Boston Medical Center who were navigated for colonoscopy screening illustrates how patients value the services of oncology patient navigators.

Prediagnostic Wine Consumption May Improve Survival After CRC

Prediagnostic Wine Consumption May Improve Survival After CRC

A possible association between moderate to heavy alcohol consumption has been shown in previous studies. In this study, investigators examined the relationship between alcohol consumption and colorectal cancer survival remains unclear.

Metabolic Syndrome Associated With Increased Risk of Esophageal Cancer in Older Patients

Metabolic Syndrome Associated With Increased Risk of Esophageal Cancer in Older Patients

A retrospective evaluation investigated the association between risk of esophageal cancer, metabolic syndrome, Barrett esophagus, and GERD in older persons.

Replacing Neoadjuvant CRT with Multiagent Chemo Not Recommended for Rectal Cancer

Replacing Neoadjuvant CRT with Multiagent Chemo Not Recommended for Rectal Cancer

In this study, the impact of advancements in surgical technique and systemic therapy for stage II and III rectal cancers was assessed via a comparison of outcomes after neoadjuvant chemoradiotherapy followed by definitive resection with those for neoadjuvant multiagent chemotherapy without radiation therapy.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

Novel Colonoscopy Prep Is Poised to Improve Screening Rates for Colon Cancer

Novel Colonoscopy Prep Is Poised to Improve Screening Rates for Colon Cancer

Novel preparation formulation is as effective and safe as current colon prep for colonoscopy. Plus, study participants gave the prep experience a high satisfaction rating.

PPIs Negatively Impact Outcomes of Patients Treated With Capecitabine

PPIs Negatively Impact Outcomes of Patients Treated With Capecitabine

Because gastric acid suppressants, such as proton pump inhibitors, affect the absorption of some oral cancer medications, researchers sought to determine if proton pump inhibitors impair capecitabine efficacy.

Kinase Inhibitors: Managing Side Effects in GI Cancers

Kinase Inhibitors: Managing Side Effects in GI Cancers

A review of adverse effects and recommended management for 3 kinase inhibitors indicated for the treatment of gastrointestinal cancers.

GERD Medications May Affect Absorption of Oral Chemotherapeutic Agents

GERD Medications May Affect Absorption of Oral Chemotherapeutic Agents

What is the interaction between oral chemotherapy and GERD medicines?

Rolapitant Improves CINV Prevention in Patients With GI Cancers

Rolapitant Improves CINV Prevention in Patients With GI Cancers

Adding rolapitant to a 5-HT3 receptor antagonist and dexamethasone significantly improved the prevention of CINV in patients with GI and CRC cancers receiving highly or moderately emetogenic chemotherapy.

Outcomes in Patients With Brain Metastasis from Esophageal Carcinoma

Outcomes in Patients With Brain Metastasis from Esophageal Carcinoma

[Journal of Gastrointestinal Oncology] This research examines factors associated with survival in patients with brain metastasis from esophageal cancer.

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

Evolutionary Theory Predicts Progression of Barrett's Esophagus to Esophageal Adenocarcinoma

Applying evolutionary theory improves the accuracy of predicting in which patients Barrett's esophagus will progress to esophageal adenocarcinoma.

Increasing Dietary Omega-3 Intake After Colorectal Cancer Diagnosis Improves Survival

Increasing Dietary Omega-3 Intake After Colorectal Cancer Diagnosis Improves Survival

Lifestyle and dietary measures for preventing colorectal cancer are extensively studied; however, in this study, researchers looked at a dietary measure that improved survival for patients after diagnosis.

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer

Poor compliance to NCCN guidelines for adjuvant chemotherapy appears to be associated with poorer overall survival.

Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer

Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer

[Journal of Gastrointestinal Oncology] This research examines outcomes related to the use of neoadjuvant multi-agent chemotherapy and stereotactic body radiation therapy (SBRT) in borderline resectable pancreatic cancer (BRPC) or locally advanced pancreatic cancer (LAPC) patients.

Metformin Use May Improve Survival in Patients With CRC, Diabetes

Research indicates that metformin can confer improved survival for patients with colorectal cancer that also have diabetes.

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

How Does Obesity Influence Pancreatic Cancer Development and Treatment?

Research findings reveal the mechanism by which obesity increases inflammation and desmoplasia in the most frequent type of pancreatic cancer, using mouse models and human tissue samples.

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer

Quality of life is significantly improved for patients with pancreatic cancer when systematic palliative care is administered vs on-demand palliative care.

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

Genetic biomarkers from tumor DNA circulating in the bloodstream could indicate the risk for recurrence of colorectal cancer and the efficacy of chemotherapy after surgery.

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

The multikinase inhibitor regorafenib significantly improved overall survival rates compared to placebo in patients with hepatocellular carcinoma, according to data from the phase 3 RESORCE trial.

In Stage II Colon Cancer, Adjuvant Chemo is Associated With Improved OS

In Stage II Colon Cancer, Adjuvant Chemo is Associated With Improved OS

Adjuvant chemotherapy is associated with improved overall survival in patients with stage II colon cancer regardless of treatment regimen, patient age, or high-risk pathologic risk features.

Computer Algorithm Matches Skilled Specialists in Detecting Early Esophageal Cancer

Using a computer algorithm to scan images of the esophagus for signs of early esophageal cancer is nearly as accurate as top specialists.

More Older Patients With Comorbidities Are Receiving Therapy for mCRC

The proportion of older patients with comorbidities receiving treatment for metastatic colorectal cancer (mCRC) has increased over the last 2 decades despite the overall percentage of older adults being treated remaining low.

Scalding Beverages Might Lead to Esophageal Cancer

Scalding Beverages Might Lead to Esophageal Cancer

Drinking scalding coffee, tea, or yerba mate might increase the risk of developing esophageal cancer according to the World Health Organization. Beverages hotter than 149°F (65°C) might increase the risk of developing esophageal cancer.

Aspirin Use Found to Prevent Cholangiocarcinoma

Aspirin Use Found to Prevent Cholangiocarcinoma

Aspirin's anti-inflammatory action is protective against another aggressive cancer: cholangiocarcinoma. Furthermore, it is beneficial regardless of daily use or dose.

Resectable Cholangiocarcinoma: Reviewing the Role of Adjuvant Strategies

Resectable Cholangiocarcinoma: Reviewing the Role of Adjuvant Strategies

[Clinical Medicine Insights: Oncology] This research examines the role of adjuvant chemotherapy in resectable bile duct cancer treatment.

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

Metastatic capabilities of pancreatic cancer might arise before tumors even form. Metastasis and advanced stage of disease at diagnosis are attributed to low survival rates for pancreatic cancer.

Gene Activity Predicts Patient Response to Inhibitor Treatment for Stomach Cancer

Measurements of copies of a single gene circulating in the bloodstream allowed scientists to identify patients with stomach cancer who were most likely to respond to treatment.

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

Combining a laboratory ultrasound technique called sonoporation with the commercially available chemotherapy compound gemcitabine increases the porosity of pancreatic cells with microbubbles and helps get the drug into cancer cells.

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

Despite the increased risk, patients whose pancreatic cancer tumor has grown to encompass critical blood vessels can be candidates for surgery. Data on efforts to fine-tune a protocol for these patients were presented at the SSAT 57th Annual Meeting.

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

Adjuvant gemcitabine plus capecitabine significantly improved overall survival compared with gemcitabine monotherapy in patients with pancreatic ductal adenocarcinoma, according to results of the ESPAC-4 trial presented at the ASCO 2016 Annual Meeting.

No Benefit for Chemoradiotherapy vs Chemotherapy After Resectable Gastric Cancer

No Benefit for Chemoradiotherapy vs Chemotherapy After Resectable Gastric Cancer

First results from the phase 3 CRITICS study found no significant difference in overall survival between postoperative chemotherapy and chemoradiotherapy in patients with resectable gastric cancer, according to a study presented at the ASCO 2016 Annual Meeting.

Survival for Patients With Liver Cancer Differs by Race

A study of nearly 1000 patients with HCC found that black patients with the disease had a 33% greater risk of death compared with non-Hispanic whites.

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

Barriers to Understanding Pancreatic Cancer Can Be Overcome With Improvements to Online Health Information

Barriers to Understanding Pancreatic Cancer Can Be Overcome With Improvements to Online Health Information

Available information on pancreatic cancer was written at too high a level and contained inaccuracies regarding alternative therapies, a recent study has shown.

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

[Journal of Gastrointestinal Oncology] This research reviews the case history of a patient with stage IVB pancreatic adenocarcinoma initially treated with gemcitabine and erlotinib who stopped therapy after 3 months without achieving a response and was switched to a different and effective combination strategy.

New Mechanism to Target RAS Genes Identified

New Mechanism to Target RAS Genes Identified

A small molecule that inhibits RAS protein interactions offers hope for targeting this elusive protein. It is one of the most sought-after cancer targets for drug developers, but the mutant RAS protein lacks drug-binding pockets.

Regular Aspirin Use May Protect Against Bile Duct Cancer

Regular Aspirin Use May Protect Against Bile Duct Cancer

People who took aspirin on a regular basis were three times less likely to develop the disease.

Readability of Online Pancreatic Cancer Info Varies

Readability of Online Pancreatic Cancer Info Varies

Lowest accuracy scores for alternative tx websites; websites with higher accuracy more difficult to read

MASCC Tool Improves Documentation of Dermatologic Toxicities of TKIs

MASCC Tool Improves Documentation of Dermatologic Toxicities of TKIs

Incorporating a modified MASCC grading tool for evaluating epidermal growth factor receptor inhibitor (EGFRI) toxicities and quality of life improved the rate of skin assessments and documentation.

Oncology Nurses Ideal for Educating Patients on Portal Vein Thrombosis

Oncology Nurses Ideal for Educating Patients on Portal Vein Thrombosis

Oncology nurses are in an ideal position to educate patients with gastrointestinal malignancies and PVT about risk factors, clinical presentation, complications, and treatment options to prevent further extension of the clot.

Nivolumab Shows Promise Against Aggressive Anal Cancer

Clinical trial results are promising for the use of nivolumab to treat squamous cell carcinoma of the anal canal, according to data presented at the 2016 American Association for Cancer Research Annual Meeting.

Targeting Drugs to Pancreatic Cancer Through Implantable Device

New research indicates a far greater efficacy in pancreatic cancer drug therapy delivered via implantable device than via IV.

Immune-stimulating Drug and Chemotherapy Show Early Promise for Pancreatic Cancer

An experimental therapy looks to hold promise for tumor control treatment in pancreatic adenocarcinoma.

AACR: Oral Bacteria Tied to Pancreatic Cancer Risk

AACR: Oral Bacteria Tied to Pancreatic Cancer Risk

Two strains of oral bacteria -- P. gingivalis and A. actinomycetemcomitans -- have been linked to higher risk of pancreatic cancer.

Navigator-specific Interventions and Multidisciplinary Care Team Collaboration Improves Care and Outcomes for Patients with GI Cancers

Navigator-specific Interventions and Multidisciplinary Care Team Collaboration Improves Care and Outcomes for Patients with GI Cancers

The GI ONN is a relatively new position whose role is not only to remove barriers to care, but also to facilitate timely, comprehensive, and evidence-based care for patients with GI cancers.

Immune System Targets for Colorectal Cancer Immunotherapies Identified in Whole-Exome Analyses

A high load of neonatigens indicates colorectal cancer (CRC) is more likely to be permeated with disease-fighting white blood cells; an influx of which often indicates an immune system attack on the cancer.

Use of Emotional Support and Acceptance Coping Strategies Lead to Better QOL and Mood in Patients With Incurable Cancer

Use of Emotional Support and Acceptance Coping Strategies Lead to Better QOL and Mood in Patients With Incurable Cancer

Patients with newly diagnosed, incurable cancer who use emotional support and acceptance coping strategies experience better quality of life (QOL) and mood; denial and self-blame strategies correlate negatively with these outcomes.

Adding Aflibercept to First-line mFOLFOX6 Does Not Improve PFS in mCRC

Adding aflibercept to first-line mFOLFOX6 did not improve progression-free survival compared with mFOLFOX6 alone in patients with mCRC, and the combination was associated with higher toxicity.

Certain Cancer Surgeries Increase Risks for Injuries and Other Health Concerns in Older Patients

Older patients who undergo surgery to treat cancer are more likely to experience injuries and other health issues such as falling down, breaking bones, dehydration, bed sores, failure to thrive, and delirium. The risks are particularly notable in patients who undergo major abdominal surgery.

Coffee Consumption May Be Associated With Lower CRC Risk

Coffee Consumption May Be Associated With Lower CRC Risk

Coffee consumption may be associated with CRC risk, with drinking more than 2.5 servings per day being associated with a 54% lower risk of developing the disease.

Gingivitis Bacteria Associated With Esophageal Cancer

Bacteria that cause gum disease, Porphyromonas gingivalis, frequently infect the esophageal tissues of patients with esophageal squamous cell carcinoma (ESCC), were associated with ESCC progression, and serve as a potential biomarker for ESCC.

Metabolic Disorder Largest Risk Factor of Hepatocellular Carcinoma

Metabolic Disorder Largest Risk Factor of Hepatocellular Carcinoma

Metabolic disorders contribute more to the incidence of hepatocellular carcinoma (HCC) incidence than any other risk factor.

Regular Aspirin Use Could Reduce Colorectal, Gastrointestinal, and Overall Cancer Risks

Regular Aspirin Use Could Reduce Colorectal, Gastrointestinal, and Overall Cancer Risks

Regular, low doses of aspirin for a minimum of 6 years correlated with a small, yet significant reduction in overall cancer risk, due primarily to reductions in risks for colorectal cancer and gastrointestinal cancer.

Experimental Immune Therapy Tears Down Protective Microenvironment of Pancreatic Cancer Tumors

Experimental Immune Therapy Tears Down Protective Microenvironment of Pancreatic Cancer Tumors

An experimental immune therapy can re-educate macrophages to tear down the scaffolding that surrounds and protects pancreatic cancer from chemotherapy.

B-DOC Regimen Plus Maintenance Feasible for Advanced Gastric Cancer

B-DOC Regimen Plus Maintenance Feasible for Advanced Gastric Cancer

Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine (B-DOC) plus maintenance therapy was feasible and active.

Adjuvant Chemotherapy More Effective in Reducing Distant Pancreatic Cancer Metastasis

Adding radiotherapy to chemotherapy and surgery reduced the number of local disease recurrences but did not affect distant recurrences or survival.

Surgical Proficiency Gains in Esophagectomy for Cancer Improve Survival

Surgical Proficiency Gains in Esophagectomy for Cancer Improve Survival

Gains in surgical proficiency in esophagectomy for cancer are associated with measurable improvements in short-term and long-term mortality results.

Reliance on PET to Detect Lung or Esophageal Cancer Recurrence May Lead to Overuse of the Imaging Modality

In posttreatment follow-up of lung and esophageal cancer, PET scans might be overused to detect cancer recurrence. Furthermore, PET scan use to detect recurrence does not increase survival.

Daily Low-Dose Aspirin May Reduce Risk of Some Cancers

Daily Low-Dose Aspirin May Reduce Risk of Some Cancers

The anti-cancer effect of low-dose aspirin was seen most strongly with colon and gastrointestinal tumors.

High-risk HPV Infection Increases Risk for Anal Cancer

Anal cancer is associated with human papillomavirus (HPV) infection, and some women are at increased likelihood of have both diseases.

Researchers Believe Pancreatic Cancer Is Four Separate Diseases

Researchers Believe Pancreatic Cancer Is Four Separate Diseases

Researchers identified four classes of genetic error that triggered pancreatic tumors and classified pancreatic cancer as four separate diseases.

Chemosensory Changes Influence Food Preferences

Chemosensory Changes Influence Food Preferences

Chemosensory and food-related changes significantly impacted food preferences and had practical and social consequences.

Neem Tree Extract Demonstrates Anticancer Activity Against Pancreatic Cancer

Neem Tree Extract Demonstrates Anticancer Activity Against Pancreatic Cancer

A natural extract from the neem tree of India is found to have potential as a treatment for pancreatic cancer.

Researchers Identify Tumor Signature That Serves as a Biomarker of at Least 5 Types of Cancer

A methylation signature was identified in 5 types of cancer, and it likely occurs in more. These findings may aid in developing a blood test to diagnose cancer at early stages, when it is most treatable.

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