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Fosinopril
CHF and arrhythmias
Hypertension
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Drug Name:

Fosinopril Rx

Generic Name and Formulations:
Fosinopril sodium 10mg+, 20mg, 40mg; tabs; +scored.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Fosinopril:

Adjunct to diuretics in heart failure, with or without digitalis.

Adult:

Initially 10mg once daily. Moderate to severe renal failure or volume depleted: initially 5mg once daily. Maintenance: 20–40mg once daily.

Children:

Contact manufacturer.

Contraindications:

History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters).

Warnings/Precautions:

Salt/volume depletion. Renal or hepatic impairment. Monitor WBCs in renal or collagen vascular disease. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Monitor for hyperkalemia in diabetics. Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Surgery. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended.

Interactions:

Potentiated by diuretics. Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements.

Pharmacological Class:

ACE inhibitor.

Adverse Reactions:

Angina, orthostatic hypotension, dizziness, cough, GI upset, pain, hyperkalemia, upper respiratory infection, arrhythmias, asthenia; angioneurotic edema (discontinue if occurs).

Note:

Formerly known under the brand name Monopril.

How Supplied:

Contact supplier.

Indications for Fosinopril:

Hypertension.

Adult:

Initially 10mg once daily. Usual maintenance: 20–40mg daily in single or 2 divided doses; max 80mg/day. If on diuretic: suspend diuretic for 2–3 days before starting if possible; resume diuretic if pressure not controlled with fosinopril alone. If diuretic cannot be discontinued: give 10mg and monitor carefully.

Children:

<6yrs (≤50kg): not recommended. ≥6yrs (>50kg): 5–10mg once daily.

Contraindications:

History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters).

Warnings/Precautions:

Salt/volume depletion. Renal or hepatic impairment. Monitor WBCs in renal or collagen vascular disease. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Monitor for hyperkalemia in diabetics. Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Surgery. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended.

Interactions:

Potentiated by diuretics. Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements.

Pharmacological Class:

ACE inhibitor.

Adverse Reactions:

Headache, cough, dizziness, GI upset, hyperkalemia, orthostatic hypotension, angioneurotic edema (discontinue if occurs).

Note:

Formerly known under the brand name Monopril.

How Supplied:

Contact supplier.

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