FORFIVO XL Rx
Generic Name and Formulations:
Bupropion HCl 450mg; ext-rel tabs.
Indications for FORFIVO XL:
Major depressive disorder.
Do not use for initiation treatment; use other bupropion forms for initial dose titration. Swallow whole. One tab (450mg) once daily. May be used in patients receiving 300mg/day of another bupropion forms for at least 2 weeks and requiring a 450mg/day dose. Taper dose using another bupropion form prior to stopping Forfivo XL. Switching from other bupropion forms at 450mg/day: give equivalent dose of Forfivo XL once daily. Switching to/from MAOIs: see full labeling.
Seizure disorders. Bulimia. Anorexia nervosa. During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, antiepileptics. Other forms of bupropion-containing products.
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients for clinical worsening or unusual behavioral changes. Monitor for neuropsychiatric adverse events (eg, behavioral changes, agitation, depression, suicidal ideation); discontinue if occur. Pre-existing psychiatric disorders. Not for treating bipolar depression or for smoking cessation. Risk of seizures; discontinue if occurs: do not restart. Monitor BP prior to initiation and periodically during treatment. Bipolar disorder. Mania/hypomania. Angle-closure glaucoma. Unstable heart disease. CHF. Recent MI. Hepatic or renal impairment: not recommended. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Do not start with concomitant linezolid or IV methylene blue; if treatment necessary, discontinue bupropion before starting. Monitor for 2 weeks or until 24hrs after last dose of linezolid or IV methylene blue, whichever comes first. Concomitant CYP2B6 inhibitors (eg, ticlopidine or clopidogrel): not recommended. Avoid alcohol. Caution with levodopa, amantadine. Caution with drugs that lower seizure threshold (eg, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). May be antagonized by CYP2B6 inducers (eg, ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin); may need bupropion dose increase. May potentiate drugs metabolized by CYP2D6 (eg, venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline, haloperidol, risperidone, thioridazine, metoprolol, propafenone, flecainide); consider dose reduction of these drugs. May antagonize tamoxifen. Monitor for hypertension with nicotine replacement. May cause false (+) urine immunoassay test results for amphetamines.
Dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash; hypertension, hypersensitivity (discontinue if occurs).
Sign Up for Free e-newsletters
- Managing Chemo Brain in Pediatric Survivors of Childhood Cancer
- Aggressive Therapy Provides No Additional Advantage in Metastatic Prostate Cancer
- Excretion of Volatile Organic Compounds Higher in AYAs Using Vaping Products
- FDA, ASHP Actions to Prevent or Manage Chemotherapy Drug Shortages
- Breast Cancer Screening Recommendations Not Completely Reflective of Race, Age
- Various Aspects of Palliative Care Focus Associated With Different Outcomes In Cancer
- Cost vs Benefits: The Controversy Over Proton Beam Radiotherapy
- Patient Expectations at Odds With Actual Outcomes for Radiotherapy in Breast Cancer
- Patients Desire More Online Tools and Access
- Metformin Plus Ruxolitinib: A Potential Therapeutic Alternative for Myeloproliferative Neoplasms
- Sexual Quality of Life Decreased During, After Chemotherapy for Digestive Cancers
- CHEMO-SUPPORT: A Nursing Intervention to Relieve Chemotherapy Symptom Burden
- Approach and Management of Checkpoint Inhibitor-related Immune Hepatitis
- Revised AJCC8 Demonstrates Superior Tumor Classification for HNCSCC
- Oral Androgen Receptor Inhibitor Granted FDA Approval for Nonmetastatic CRPC
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|