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FEMRING
Menopause and HRT
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Drug Name:

FEMRING Rx

Generic Name and Formulations:
Estradiol acetate 0.05mg/day, 0.1mg/day; vaginal ring.

Company:
Allergan

Therapeutic Use:

Indications for FEMRING:

Moderate to severe vasomotor symptoms or vulvar and vaginal atrophy due to menopause.

Adult:

Use lowest effective dose for shortest duration consistent with treatment goals. Insert 1 ring vaginally once every 3 months; replace. Initially 0.05mg/day ring; may increase to 0.1mg/day ring if needed.

Children:

Not applicable.

Contraindications:

Thrombophlebitis or thromboembolic disorders. Protein C, protein S, or antithrombin deficiency, or other thrombophilias. Breast or other estrogen-dependent neoplasms. Undiagnosed abnormal genital bleeding. Hepatic disease or tumors. Pregnancy.

Warnings/Precautions:

Not for the prevention of cardiovascular disease or dementia. Increased risk of endometrial cancer in women with a uterus using unopposed estrogens; consider adding progestin to reduce the risk of endometrial hyperplasia. Risk of invasive breast cancer with estrogen/progestin combination. Discontinue if thrombotic event, unexplained visual changes, or jaundice occurs, and at least 4 weeks before through 2 weeks after surgery associated with increased risk of thromboembolism. Diabetes. Hypertriglyceridemia. Gallbladder disease. Metabolic bone disease associated with hypercalcemia. Pregnancy-related cholestasis. Hypothyroidism (monitor). Fluid retention. Hypoparathyroidism. Residual endometriosis post-hysterectomy; consider adding progestin. Hereditary angioedema. Asthma. Epilepsy. Migraines. Porphyria. SLE. Hepatic hemangiomas. Women with a predisposition to vaginal irritation, ulceration, or ring expulsion (eg, vaginal stenosis, cervical prolapse, rectoceles, cystoceles). May use ring while treating vaginal infections. Do regular complete physical exams. Reevaluate periodically. Nursing mothers: not recommended.

Interactions:

May be affected by CYP3A4 inducers or inhibitors. May affect lab tests (eg, coagulation factors, triglycerides, lipids, glucose tolerance, binding proteins, hormone binding globulins, thyroid).

Pharmacological Class:

Estrogen.

Adverse Reactions:

Vaginal bleeding, breast tenderness, vaginal candidiasis, headache; serious thromboembolic events, malignant neoplasms.

Generic Availability:

NO

How Supplied:

Ring—1

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