Hair Dyes and Cancer Risk (Fact Sheet)
Hair Dyes and Cancer Risk (Fact Sheet)
Why is there concern that hair dyes may cause cancer?
Many people in the United States and Europe use hair dyes. It is estimated that more than one-third of women over age 18 and about 10 percent of men over age 40 use some type of hair dye (1).
Modern hair dyes are classified as permanent (or oxidative), semipermanent, and temporary. Permanent hair dyes, which make up about 80 percent of currently marketed products, consist of colorless dye “intermediates” (chemicals called aromatic amines) and dye “couplers.” In the presence of hydrogen peroxide, the intermediates and couplers react with one another to form pigment molecules. Darker colors are formed by using higher concentrations of intermediates. Semipermanent and temporary hair dyes are nonoxidative and include colored compounds that stain hair directly.
Over 5,000 different chemicals are used in hair dye products, some of which are reported to be carcinogenic (cancer-causing) in animals (2, 3). Because so many people use hair dyes, scientists have tried to determine whether exposure to the chemicals in hair coloring products is associated with an increased risk of cancer in people.
Early hair dye formulations contained chemicals, including aromatic amines that were found to cause cancer in animals. In the mid- to late 1970s, however, manufacturers changed the components in dye products to eliminate some of these chemicals (2–4). It is not known whether some of the chemicals still used in hair dyes can cause cancer. Given the widespread use of hair dye products, even a small increase in risk may have a considerable public health impact (3).
Over the years, some epidemiologic (population) studies have found an increased risk of bladder cancer in hairdressers and barbers (2, 5). A 2008 report of the Working Group of the International Agency for Research on Cancer (IARC) concluded that some of the chemicals these workers are exposed to occupationally are “probably carcinogenic to humans” (6).
Although some studies have linked the personal use of hair dyes with increased risks of certain cancers of the blood and bone marrow, such as non-Hodgkin lymphoma (NHL) and leukemia, other studies have not shown such links. Studies of breast and bladder cancer have also produced conflicting results. Relatively few studies have been published about the association of hair dye use with the risk of other cancers (4). Based on its review of the evidence, IARC concluded that personal use of hair dyes is “not classifiable as to its carcinogenicity to humans” (6).
What is the evidence that personal hair dye use is associated with risk of NHL?
A number of studies have investigated the relationship between the personal use of hair dyes and the risk of NHL, with conflicting results. Because the small size of some studies may have limited their ability to detect an association between hair dye use and cancer, a pooled (combined) analysis of four case-control studies was carried out (7). All four studies had obtained detailed information on hair dye use, including dates and duration of use, and on NHL subtype. The pooled analysis included 4,461 women with NHL and 5,799 women who did not have NHL. The results of the study showed that women who began using hair dye before 1980 had a slightly (30 percent) increased risk of NHL compared with women who had never used hair dye, whereas no such increase in risk was seen for women who began using hair dye after 1980.
When the researchers analyzed the risks of several specific NHL subtypes, they found that hair dye users had increased risks of both follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (7). For the most part, the increases were limited to women who began using hair dye before 1980, although an increased risk of follicular lymphoma was observed among women who began using dark-colored dyes after 1980. Although these results are consistent with the idea that earlier hair dyes were more carcinogenic, it is also possible that the absence of increased risks for hair dye users who began using dyes after 1980 reflects lowercumulative exposure levels or insufficient time since first exposure for any increase in risk to become apparent.
What is the evidence that personal hair dye use is associated with risk of leukemia?
Studies of the association between personal hair dye use and the risk of leukemia have had conflicting results. For example, one case-control study examined hair dye use among 769 patients with adult acute leukemia and 623 people without leukemia in the United States and Canada (8). It found that the risks of acute leukemia were higher among users of earlier formulations of both permanent and nonpermanent (i.e., semipermanent and temporary) dyes than among those who had not used dyes, although the increases were not statistically significant. No risk increases were seen among users of more recent dye formulations. Risk was greatest among those who had used permanent dyes for longer durations (15 or more years).
However, a case-control study in Italy found no association between use of permanent hair dye overall and risk of leukemia, although users of black permanent dyes, but not of other color dyes, did have an increased risk. This study, however, did not collect information on the timing or frequency of hair dye use (9).
What is the evidence that personal hair dye use is associated with risk of bladder cancer?
Research on personal hair dye use and the risk of bladder cancer has produced conflicting results.
An analysis of data pooled from 12 studies of personal hair dye use found no evidence of an increased risk of bladder cancer (10). However, research on the use of permanent hair dyes specifically has produced conflicting results. Some recent studies have suggested an increased risk of bladder cancer associated with the use of permanent hair dyes (11–13), whereas other studies have not (14–16).
Because studies have shown that professional hairdressers have an increased risk of bladder cancer that may be due to occupational exposure to hair dye (2, 5), researchers will continue to study whether personal hair dye use is related to bladder cancer risk.
What is the evidence that personal hair dye use is associated with risks of other cancers?
Researchers who reviewed data from 14 studies of female breast cancer and hair dye use published between 1977 and 2002 found that dye users had no increase in the risk of breast cancer compared with nonusers (4).
Research on hair dye use and the risks of other cancers is more limited. Although some studies have shown associations between hair dye use and the risk of developing or dying from specific cancers, these associations have not been seen in other studies. Because of differences in study design, it has not been possible to pool the results of studies of most cancer types to increase the power to detect associations with hair dye use.
Where can a person find more information about hair dyes?
Information about specific hair dye ingredients is available from the National Toxicology Program (NTP), an interagency program of the U.S. Department of Health and Human Services. NTP's 12th Report on Carcinogens identifies agents, substances, or chemical mixtures that cause or might cause cancer in humans. A copy of the report (plus PDF file on CD or PDF file on USB flash drive) can be requested by e-mail.
The Outreach and Information Center of the U.S. Food and Drug Administration's Center for Food Safety and Applied Nutrition has information about hair dyes and how they are regulated. The Center can be contacted at:
U.S. Food and Drug Administration
Center for Food Safety and Applied Nutrition (HFS-009)
Outreach and Information Center
5100 Paint Branch Parkway
College Park, MD 20740
Selected References1. Huncharek M, Kupelnick B. Personal use of hair dyes and the risk of bladder cancer: results of a meta-analysis. Public Health Reports 2005; 120(1):31–38. [PubMed Abstract]
2. Bolt HM, Golka K. The debate on carcinogenicity of permanent hair dyes: new insights. Critical Reviews in Toxicology 2007; 37(6):521–536. [PubMed Abstract]
3. de Sanjose S, Benavente Y, Nieters A, et al. Association between personal use of hair dyes and lymphoid neoplasms in Europe. American Journal of Epidemiology 2006; 164(1):47–55. [PubMed Abstract]
4. Takkouche B, Etminan M, Montes-Martinez A. Personal use of hair dyes and risk of cancer: a meta-analysis. JAMA: The Journal of the American Medical Association 2005; 293(20):2516–2525. [PubMed Abstract]
5. Harling M, Schablon A, Schedlbauer G, Dulon M, Nienhaus A. Bladder cancer among hairdressers: a meta-analysis. Occupational and Environmental Medicine 2010; 67(5):351–358.[PubMed Abstract]
6. Baan R, Straif K, Grosse Y, et al. Carcinogenicity of some aromatic amines, organic dyes, and related exposures. Lancet Oncology 2008; 9(4):322–323. [PubMed Abstract]
7. Zhang Y, de Sanjose S, Bracci PM, et al. Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphoma. American Journal of Epidemiology 2008; 167(11):1321–1331.[PubMed Abstract]
8. Rauscher GH, Shore D, Sandler DP. Hair dye use and risk of adult acute leukemia. American Journal of Epidemiology 2004; 160(1):19–25. [PubMed Abstract]
9. Miligi L, Costantini AS, Benvenuti A, et al. Personal use of hair dyes and hematolymphopoietic malignancies. Archives of Environmental and Occupational Health 2005; 60(5):249–256. [PubMed Abstract]
10. Kelsh MA, Alexander DD, Kalmes RM, Buffler PA. Personal use of hair dyes and risk of bladder cancer: a meta-analysis of epidemiologic data. Cancer Causes and Control 2008; 19(6):549–558.[PubMed Abstract]
11. Andrew AS, Schned AR, Heaney JA, Karagas MR. Bladder cancer risk and personal hair dye use.International Journal of Cancer 2004; 109(4):581–586. [PubMed Abstract]
12. Gago-Dominguez M, Castelao JE, Yuan JM, Yu MC, Ross RK. Use of permanent hair dyes and bladder-cancer risk. International Journal of Cancer 2001; 91(4):575–579. [PubMed Abstract]
13. Koutros S, Silverman DT, Baris D, et al. Hair dye use and risk of bladder cancer in the New England bladder cancer study. International Journal of Cancer 2011; DOI:10.1002/ijc.26245.[PubMed Abstract]
14. Henley SJ, Thun MJ. Use of permanent hair dyes and bladder-cancer risk. International Journal of Cancer 2001; 94(6):903–906. [PubMed Abstract]
15. Kogevinas M, Fernandez F, Garcia-Closas M, et al. Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in Spain. European Journal of Cancer 2006; 42(10):1448–1454. [PubMed Abstract]
16. Lin J, Dinney CP, Grossman HB, Wu X. Personal permanent hair dye use is not associated with bladder cancer risk: evidence from a case-control study. Cancer Epidemiology Biomarkers and Prevention 2006; 15(9):1746–1749. [PubMed Abstract]Source: National Cancer Institute