Ewing Sarcoma

New Therapy Holds Promise for Patients With Ewing Sarcoma

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Two new compounds suppress tumor growth in cell culture and mouse xenograft models of Ewing sarcoma, a rare pediatric cancer. These 2 compounds are similar to mithramycin, also known as picamycin, a drug no longer manufactured due to its toxicity.

Potential treatment option discovered for children with Ewing's sarcoma

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Combining two anti-tumor agents appears to increase the sensitivity of cancer cells to these drugs and seems to lead to more effective Ewing's sarcoma treatment.

Endoscopic extraction of spinal tumor achieves diagnosis and successful treatment

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The first reported case of endoscopic spinal tumor extraction enabled accurate diagnosis and allowed for patient reporting of sensations and motor testing.

Potential therapeutic strategy against a very aggressive children's bone cancer

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Inhibiting the protein Sirtuin1 could play a part in fighting Ewing sarcoma, a common bone cancer in adolescents and children.

Single genetic abnormality important in Ewing sarcoma

Single genetic abnormality important in Ewing sarcoma

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Better understanding of the two distinct processes at the heart of the genetic abnormality driving Ewing sarcoma development could lead to new, more effective therapies.

Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma

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When Ewing sarcoma tumors in mice were treated with combination therapy that included drugs from a family of agents developed to fight breast cancer, the tumors disappeared in a majority of test cases.

PARP inhibitors plus chemotherapy may be effective for Ewing sarcoma

PARP inhibitors plus chemotherapy may be effective for Ewing sarcoma

A combination of experimental drugs caused Ewing sarcoma tumors to disappear in mice.

Possible druggable target for Ewing sarcoma

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Ewing sarcoma is most commonly caused by the improper fusion of the gene EWS with the gene FLI1. Though the cause has long been known, therapeutic targeting of this fusion has, to date, proven difficult.

Possible new treatment for Ewing sarcoma

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Discovery of a new drug with high potential to treat Ewing sarcoma and of the previously unknown mechanism behind the disease came hand-in-hand.

Deviations from radiation protocols increase the risk of treatment failure and death

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When measures are implemented to ensure that radiation protocols are followed, deviations decrease and overall survival improves in patients with cancer.

More intensive chemo ups survival in Ewing sarcoma

More intensive chemo ups survival in Ewing sarcoma

No increased toxicity with increasing chemo from every three weeks to every two weeks.

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