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Etidronate Disodium
Bone disorders
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Drug Name:

Etidronate Disodium Rx

Generic Name and Formulations:
Etidronate disodium 200mg, 400mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Etidronate Disodium:

Treatment of symptomatic Paget's disease of bone. Prevention and treatment of heterotopic ossification after total hip replacement or due to spinal cord injury.

Adult:

Swallow whole; take with a full glass of water (6–8oz) in upright position; do not lie down afterwards. Give once daily (preferred) or in divided doses at least 2hrs before or after food. Paget's: initially 5–10mg/kg/day; max 6 months (if ineffective, or if rapid bone turnover must be suppressed or to reduce elevated cardiac output: 11–20mg/kg/day; max 3 months). May retreat after 3 etidronate-free months if evidence of active disease process exists. Heterotopic ossification: hip replacement: 20mg/kg/day for 1 month before and 3 months after surgery; spinal cord injury: 20mg/kg/day for 2 weeks, then 10mg/kg/day for 10 weeks.

Children:

Not established.

Contraindications:

Esophagus abnormalities which delay esophageal emptying (eg, stricture, achalasia). Clinically overt osteomalacia.

Warnings/Precautions:

Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Ensure adequate calcium and Vit. D intake. Risk of osteonecrosis of the jaw; consider discontinuing therapy during invasive dental procedures (eg, tooth extraction, implants, surgery). Enterocolitis. Osteomalacia and increased fracture risk in chronic use or high doses. Osteolytic lesions. Renal dysfunction: reduce dose. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Calcium, aluminum- or magnesium-containing antacids, iron, other divalent cations reduce absorption (separate dosing by >2hrs). Monitor warfarin.

Pharmacological Class:

Diphosphonate.

Adverse Reactions:

Diarrhea, nausea, musculoskeletal pain, esophagitis, esophageal ulcers/erosions, gastritis (may be severe); osteomalacia, bone fractures, jaw osteonecrosis.

Note:

Formerly known under the brand name Didronel.

How Supplied:

Contact supplier.

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