ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ETHYOL
Cytoprotective and supportive care agents
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ETHYOL Rx

Generic Name and Formulations:
Amifostine 500mg/vial; pwd for IV infusion after reconstitution.

Company:
MedImmune, Inc.

Therapeutic Use:

Indications for ETHYOL:

To reduce cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. To reduce xerostomia in patients undergoing post-op radiation therapy for head and neck cancer where the radiation port includes a substantial portion of the parotid glands.

Adult:

Pretreat with antiemetics. Reduction of renal toxicity: 910mg/m2 by IV infusion over 15 minutes once daily, starting 30 minutes before chemotherapy; monitor BP every 5 minutes during infusion and thereafter, interrupt infusion if systolic BP decreases significantly; if BP returns to normal after 5 minutes, may restart; if full dose cannot be given, then give dose of 740mg/m2 for subsequent cycles. Xerostomia: 200mg/m2 by IV infusion over 3 minutes once daily, starting 15–30 minutes before standard fraction radiation therapy; monitor BP before and immediately after infusion.

Children:

Not established.

Warnings/Precautions:

Do not use for other malignancies in which chemotherapy can produce a significant survival benefit or in patients receiving definitive radiotherapy (except in a clinical trial). Not recommended for hypotensive or dehydrated patients. Stop BP medication 24 hours before therapy when using as a chemoprotectant (do not give to patients unable to stop antihypertensives). Monitor prior to, during and after therapy; discontinue if severe cutaneous reactions, mucosal lesions, or allergic reactions occur. Ensure adequate hydration. Keep patient in supine position. Hypocalcemia risk (eg, nephrotic syndrome, multiple doses of Ethyol); monitor serum calcium. Cardiovascular or cerebrovascular disease (ischemic heart disease, arrhythmias, CHF, stroke or TIA). Elderly. Pregnancy. Nursing mothers: not recommended.

Interactions:

Caution with drugs that can cause hypotension.

Adverse Reactions:

Hypotension, hypersensitivity, nausea, vomiting, flushing, chills, malaise, fever, rash, dizziness, somnolence, hiccups, sneezing, diplopia, blurred vision, inj site reactions; rarely: severe skin reactions (eg, erythema multiforme, SJS, TEN, DRESS), reversible loss of consciousness, hypocalcemia, respiratory and cardiac arrest, renal failure, arrythmias, hypertension, seizures, syncope.

How Supplied:

Single-use vials—3

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs