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Estazolam
Sleep-wake disorders
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Drug Name:

Estazolam CIV

Generic Name and Formulations:
Estazolam 1mg, 2mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Estazolam:

Short-term treatment of insomnia.

Adult:

Initially 1mg at bedtime. May increase to 2mg nightly. Small or debilitated elderly: initially 0.5mg.

Children:

<18yrs: not recommended.

Contraindications:

Concomitant ketoconazole, itraconazole. Pregnancy (Cat.X).

Warnings/Precautions:

Drug or alcohol abuse. Suicidal tendencies. Depression. Renal, hepatic, or respiratory impairment. Avoid abrupt cessation after prolonged use. Elderly. Debilitated. Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Caution with CYP3A inhibitors (eg, nefazodone, fluvoxamine, cimetidine, diltiazem, isoniazid, other macrolides): consider dose reduction.

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

CNS depression, complex sleep-related behaviors (eg, sleep-driving), hypokinesia, dizziness, incoordination, confusion, constipation, anxiety, paradoxical excitement; anaphylaxis, angioedema.

Note:

Formerly known under the brand name Prosom.

How Supplied:

Contact supplier.

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