Endometriosis Linked to Higher Ovarian Cancer Risk

Share this article:
Endometriosis Linked to Higher Ovarian Cancer Risk
Endometriosis Linked to Higher Ovarian Cancer Risk

(HealthDay News) -- A history of endometriosis increases the risk of developing ovarian cancer, although the increased risk is restricted to specific subtypes of invasive ovarian cancer, according to a meta-analysis published online Feb. 22 in The Lancet Oncology.

Celeste Leigh Pearce, Ph.D., from the University of Southern California in Los Angeles, and colleagues pooled data from 13 case-control studies, including 13,226 controls and 7,911 women with invasive ovarian cancer, to assess the association between endometriosis and histological subtypes of ovarian cancer.

The researchers found that 818 of the controls and 738 women with ovarian cancer reported a history of endometriosis. Women with borderline ovarian cancer were also included in the analysis, and 168 of 1,907 reported having endometriosis. Self-reported endometriosis correlated with a significantly elevated risk of clear-cell ovarian cancers (20.2 percent of cases versus 6.2 percent of controls; odds ratio [OR], 3.05); low-grade serous ovarian cancers (9.2 percent of cases; OR, 2.11); and endometrioid invasive ovarian cancers (13.9 percent of cases; OR, 2.04). There was no correlation seen between endometriosis and the risk of mucinous ovarian cancer (OR, 1.02; P = 0.93), high-grade serous invasive ovarian cancer (OR, 1.13; P = 0.13), or borderline serous or mucinous tumors (OR, 1.20; P = 0.12 and OR, 1.12; P = 0.45, respectively).

"Clinicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

This article originally appeared here.
Share this article:
You must be a registered member of ONA to post a comment.
close

Next Article in Daily Oncology News

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in Daily Oncology News

Unplanned hospitalizations among gastrointestinal cancer patients common

Unplanned hospitalizations among gastrointestinal cancer patients common

Among elderly patients with gastrointestinal cancer, unplanned hospitalizations are common, according to online research.

70-Gene signature not likely to be cost-effective for breast cancer

70-Gene signature not likely to be cost-effective for ...

Findings in comparative economic analysis of patients with node-negative breast cancer showed the 70-gene signature is unlikely to be cost-effective for guiding adjuvant chemotherapy decision making.

Many clinicians feel mobile apps can improve patient outcomes

Many clinicians feel mobile apps can improve patient ...

Many physicians believe digital communication technologies, including mobile apps, can be of benefit to their patients.