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ENABLEX
Overactive bladder/enuresis
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Drug Name:

ENABLEX Rx

Generic Name and Formulations:
Darifenacin (as HBr) 7.5mg, 15mg; ext-rel tabs.

Company:
Allergan

Therapeutic Use:

Indications for ENABLEX:

Overactive bladder with symptoms of urge urinary incontinence, urgency and frequency.

Adult:

Swallow whole with liquid. Initially 7.5mg once daily; may increase to 15mg once daily after 2 weeks. Max 7.5mg once daily in moderate hepatic impairment or with potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin, nefazadone).

Children:

Not recommended.

Contraindications:

Urinary or gastric retention; uncontrolled narrow-angle glaucoma; or patients at risk for these.

Warnings/Precautions:

Severe hepatic impairment: not recommended. GI or GU obstruction. Severe constipation. Ulcerative colitis. Myasthenia gravis. Controlled narrow-angle glaucoma. High environmental temperatures. Discontinue if angioedema with upper airway swelling occurs. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiated by CYP3A4 inhibitors (see Dose). May potentiate CYP2D6 substrates with narrow therapeutic indexes (eg, flecainide, thioridazine, antidepressants). Additive anticholinergic effects with other anticholinergics.

Pharmacological Class:

Antispasmodic/anticholinergic.

Adverse Reactions:

Anticholinergic effects (eg, dry mouth, blurred vision), CNS effects (eg, headache, confusion, hallucinations, somnolence; consider reducing dose or discontinuing if occurs).UTI, headache, GI upset, accidental injury, flu symptoms, decreased GI motility (may affect absorption of other drugs).

How Supplied:

Tabs—30, 90

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